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Article: Endotoxin-neutralizing peptides as gram-negative sepsis therapeutics

TitleEndotoxin-neutralizing peptides as gram-negative sepsis therapeutics
Authors
KeywordsAnti-microbial peptide
BPIP
CD18
Endotoxin-neutralizing peptide
Gram-negative sepsis
Issue Date2009
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/ppl/index.htm
Citation
Protein And Peptide Letters, 2009, v. 16 n. 5, p. 539-542 How to Cite?
AbstractBacterial endotoxin [e.g. lipopolysaccharide (LPS)] can trigger systemic hyper-inflammatory that subsequently leads to multiple organ failure and lethality (gram-negative sepsis). This paper describes the development of endotoxin- neutralizing peptides that potentially treat sepsis. These peptides have been derived from bactericidal/permeability- increasing protein (BPIP), anti-microbial peptides, and leukocyte CD18 antigen and some of these peptides have been tested in clinical studies. © 2009 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/84381
ISSN
2015 Impact Factor: 1.069
2015 SCImago Journal Rankings: 0.472
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KFen_HK
dc.contributor.authorLuk, JMen_HK
dc.date.accessioned2010-09-06T08:52:16Z-
dc.date.available2010-09-06T08:52:16Z-
dc.date.issued2009en_HK
dc.identifier.citationProtein And Peptide Letters, 2009, v. 16 n. 5, p. 539-542en_HK
dc.identifier.issn0929-8665en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84381-
dc.description.abstractBacterial endotoxin [e.g. lipopolysaccharide (LPS)] can trigger systemic hyper-inflammatory that subsequently leads to multiple organ failure and lethality (gram-negative sepsis). This paper describes the development of endotoxin- neutralizing peptides that potentially treat sepsis. These peptides have been derived from bactericidal/permeability- increasing protein (BPIP), anti-microbial peptides, and leukocyte CD18 antigen and some of these peptides have been tested in clinical studies. © 2009 Bentham Science Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/ppl/index.htmen_HK
dc.relation.ispartofProtein and Peptide Lettersen_HK
dc.subjectAnti-microbial peptideen_HK
dc.subjectBPIPen_HK
dc.subjectCD18en_HK
dc.subjectEndotoxin-neutralizing peptideen_HK
dc.subjectGram-negative sepsisen_HK
dc.subject.meshAmino Acid Sequence-
dc.subject.meshEndotoxins - antagonists and inhibitors - metabolism-
dc.subject.meshGram-Negative Bacteria - drug effects - physiology-
dc.subject.meshPeptides - chemistry - metabolism - pharmacology - therapeutic use-
dc.subject.meshSepsis - drug therapy-
dc.titleEndotoxin-neutralizing peptides as gram-negative sepsis therapeuticsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0929-8665&volume=16&issue=5&spage=539&epage=542&date=2009&atitle=Endotoxin-neutralizing+peptides+as+gram-negative+sepsis+therapeuticsen_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/092986609788167761en_HK
dc.identifier.pmid19442233-
dc.identifier.scopuseid_2-s2.0-67649385970en_HK
dc.identifier.hkuros168581en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649385970&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue5en_HK
dc.identifier.spage539en_HK
dc.identifier.epage542en_HK
dc.identifier.isiWOS:000265799400012-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridWong, KF=35081410800en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.citeulike4447208-

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