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Article: Endoscopic resection of malignant tumors of the nose and sinuses

TitleEndoscopic resection of malignant tumors of the nose and sinuses
Authors
KeywordsEndoscopic sinus surgery
Malignant nasal tumor
Malignant sinus tumor
Issue Date2007
PublisherOceanSide Publications, Inc. The Journal's web site is located at http://www.oceansidepubl.com/rhinology.html
Citation
American Journal Of Rhinology, 2007, v. 21 n. 1, p. 89-94 How to Cite?
AbstractBackground: Since the introduction of endoscopic surgery, its role has been gradually extended to encompass a range of pathologies, including sinonasal tumors, facilitated by the ability to repair significant skull-base defects. However, the rarity and long natural history of malignant tumors make it difficult to accrue cohorts comparable with the established gold standard of craniofacial resection. Methods: In this prospective cohort study, after histological confirmation and a staging imaging protocol, patients deemed suitable were offered the option of an entirely endoscopic resection as an alternative to craniofacial resection. The procedure was performed under frozen section control. The long-term follow-up protocol included both MRI and examination under anesthesia at 3- to 4-month intervals in the first 2 years and 6-month intervals thereafter. Results: There were 49 patients, 26 men and 23 women, aged 34-88 years (mean, 60 years). Follow-up ranged from 6 to 126 months (mean, 36 months). Thirty-seven cases underwent radiotherapy and 14 cases underwent adjuvant chemotherapy. A wide range of pathologies included 15 cases of adenocarcinoma, 11 malignant melanomas, and 11 olfactory neuroblastomas. Hospital stay was a mean of 5 days, with no significant postoperative complications. Thirty-six patients are alive and well, 7 patients have residual disease, 4 patients are dead of disease, and 2 patients have died of intercurrent disease. Three patients have been subsequently converted to craniofacial resection. Overall survival was 88% at 5 years. Conclusion: These initial results suggest that endoscopic resection may provide an alternative to craniofacial resection in selected cases of sinonasal malignancy. Copyright © 2007, OceanSide Publications, Inc., U.S.A.
Persistent Identifierhttp://hdl.handle.net/10722/84370
ISSN
2008 Impact Factor: 1.553
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLund, Ven_HK
dc.contributor.authorHoward, DJen_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2010-09-06T08:52:08Z-
dc.date.available2010-09-06T08:52:08Z-
dc.date.issued2007en_HK
dc.identifier.citationAmerican Journal Of Rhinology, 2007, v. 21 n. 1, p. 89-94en_HK
dc.identifier.issn1050-6586en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84370-
dc.description.abstractBackground: Since the introduction of endoscopic surgery, its role has been gradually extended to encompass a range of pathologies, including sinonasal tumors, facilitated by the ability to repair significant skull-base defects. However, the rarity and long natural history of malignant tumors make it difficult to accrue cohorts comparable with the established gold standard of craniofacial resection. Methods: In this prospective cohort study, after histological confirmation and a staging imaging protocol, patients deemed suitable were offered the option of an entirely endoscopic resection as an alternative to craniofacial resection. The procedure was performed under frozen section control. The long-term follow-up protocol included both MRI and examination under anesthesia at 3- to 4-month intervals in the first 2 years and 6-month intervals thereafter. Results: There were 49 patients, 26 men and 23 women, aged 34-88 years (mean, 60 years). Follow-up ranged from 6 to 126 months (mean, 36 months). Thirty-seven cases underwent radiotherapy and 14 cases underwent adjuvant chemotherapy. A wide range of pathologies included 15 cases of adenocarcinoma, 11 malignant melanomas, and 11 olfactory neuroblastomas. Hospital stay was a mean of 5 days, with no significant postoperative complications. Thirty-six patients are alive and well, 7 patients have residual disease, 4 patients are dead of disease, and 2 patients have died of intercurrent disease. Three patients have been subsequently converted to craniofacial resection. Overall survival was 88% at 5 years. Conclusion: These initial results suggest that endoscopic resection may provide an alternative to craniofacial resection in selected cases of sinonasal malignancy. Copyright © 2007, OceanSide Publications, Inc., U.S.A.en_HK
dc.languageengen_HK
dc.publisherOceanSide Publications, Inc. The Journal's web site is located at http://www.oceansidepubl.com/rhinology.htmlen_HK
dc.relation.ispartofAmerican Journal of Rhinologyen_HK
dc.subjectEndoscopic sinus surgeryen_HK
dc.subjectMalignant nasal tumoren_HK
dc.subjectMalignant sinus tumoren_HK
dc.titleEndoscopic resection of malignant tumors of the nose and sinusesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1050-6586&volume=21&spage=89&epage=94&date=2007&atitle=Endoscopic+resection+of+malignant+tumors+of+the+nose+and+sinusesen_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2500/ajr.2007.21.2957en_HK
dc.identifier.pmid17283568-
dc.identifier.scopuseid_2-s2.0-33846924105en_HK
dc.identifier.hkuros126166en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846924105&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue1en_HK
dc.identifier.spage89en_HK
dc.identifier.epage94en_HK
dc.identifier.isiWOS:000243856100017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLund, V=7102840344en_HK
dc.identifier.scopusauthoridHoward, DJ=7202305361en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.citeulike1080998-

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