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Article: Immediate and long-term outcomes of hepatectomy for hepatolithiasis

TitleImmediate and long-term outcomes of hepatectomy for hepatolithiasis
Authors
Issue Date2004
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/surg
Citation
Surgery, 2004, v. 135 n. 4, p. 386-393 How to Cite?
AbstractObjective. The aim of this study was to evaluate the perioperative and long-term results of hepatectomy for hepatolithiasis. Patients and methods. Immediate and long-term outcomes of 103 consecutive patients with hepatolithiasis who underwent hepatectomy from 1989 to 2001 were analyzed. Immediate outcomes included stone clearance rate, operative morbidity, and mortality. Long-term results included stone recurrence rate and survival. Results. The immediate stone clearance rate was 90%, and the final stone clearance rate was 98% after subsequent choledochoscopic lithotripsy by cutaneous stoma or T-tube route. The operative morbidity and hospital mortality rates were 28% and 2%, respectively. Multivariate analysis showed that right hepatectomy (P = .006) and preoperative hyperbilirubinemia (P = .038) were predictive of postoperative complications. Ten patients (10%) had associated cholangiocarcinoma (four known preoperatively) at the time of hepatectomy. With a median follow-up of 56 months (range 6-158), recurrent stones developed in eight patients and cholangiocarcinoma developed in three patients (range: 7-30 months postoperatively). Sixteen patients had died during the follow-up period, none of recurrent cholangitis. Cholangiocarcinoma was the only significant prognostic factor of long-term survival by Cox regression analysis. Conclusions. Hepatectomy is a safe and effective treatment for hepatolithiasis, with a high immediate stone clearance rate and a low long-term stone recurrence rate. The presence of associated cholangiocarcinoma is the main factor compromising long-term survival in patients with hepatolithiasis.
Persistent Identifierhttp://hdl.handle.net/10722/84363
ISSN
2015 Impact Factor: 3.309
2015 SCImago Journal Rankings: 1.620
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, DWen_HK
dc.contributor.authorTungPing Poon, Ren_HK
dc.contributor.authorLiu, CLen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:52:04Z-
dc.date.available2010-09-06T08:52:04Z-
dc.date.issued2004en_HK
dc.identifier.citationSurgery, 2004, v. 135 n. 4, p. 386-393en_HK
dc.identifier.issn0039-6060en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84363-
dc.description.abstractObjective. The aim of this study was to evaluate the perioperative and long-term results of hepatectomy for hepatolithiasis. Patients and methods. Immediate and long-term outcomes of 103 consecutive patients with hepatolithiasis who underwent hepatectomy from 1989 to 2001 were analyzed. Immediate outcomes included stone clearance rate, operative morbidity, and mortality. Long-term results included stone recurrence rate and survival. Results. The immediate stone clearance rate was 90%, and the final stone clearance rate was 98% after subsequent choledochoscopic lithotripsy by cutaneous stoma or T-tube route. The operative morbidity and hospital mortality rates were 28% and 2%, respectively. Multivariate analysis showed that right hepatectomy (P = .006) and preoperative hyperbilirubinemia (P = .038) were predictive of postoperative complications. Ten patients (10%) had associated cholangiocarcinoma (four known preoperatively) at the time of hepatectomy. With a median follow-up of 56 months (range 6-158), recurrent stones developed in eight patients and cholangiocarcinoma developed in three patients (range: 7-30 months postoperatively). Sixteen patients had died during the follow-up period, none of recurrent cholangitis. Cholangiocarcinoma was the only significant prognostic factor of long-term survival by Cox regression analysis. Conclusions. Hepatectomy is a safe and effective treatment for hepatolithiasis, with a high immediate stone clearance rate and a low long-term stone recurrence rate. The presence of associated cholangiocarcinoma is the main factor compromising long-term survival in patients with hepatolithiasis.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/surgen_HK
dc.relation.ispartofSurgeryen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAlgorithmsen_HK
dc.subject.meshCholangiocarcinoma - complications - mortality - surgeryen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatectomy - methodsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLithiasis - complications - surgeryen_HK
dc.subject.meshLiver Diseases - complications - surgeryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshSurvival Analysisen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleImmediate and long-term outcomes of hepatectomy for hepatolithiasisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0263-9319&volume=135&issue=4&spage=386&epage=393&date=2004&atitle=Immediate+and+long-term+outcomes+of+hepatectomy+for+hepatolithiasisen_HK
dc.identifier.emailTungPing Poon, R: poontp@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityTungPing Poon, R=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.surg.2003.09.007en_HK
dc.identifier.pmid15041962-
dc.identifier.scopuseid_2-s2.0-1842504397en_HK
dc.identifier.hkuros85908en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1842504397&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume135en_HK
dc.identifier.issue4en_HK
dc.identifier.spage386en_HK
dc.identifier.epage393en_HK
dc.identifier.isiWOS:000220556900005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChen, DW=14067165600en_HK
dc.identifier.scopusauthoridTungPing Poon, R=7103097223en_HK
dc.identifier.scopusauthoridLiu, CL=7409789712en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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