File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Adjuvant therapy for the reduction of postoperative intra-abdominal adhesion formation

TitleAdjuvant therapy for the reduction of postoperative intra-abdominal adhesion formation
Authors
KeywordsAbdominal
Adhesion
Postoperative
Prevention
Reduction
Issue Date2009
PublisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description
Citation
Asian Journal Of Surgery, 2009, v. 32 n. 3, p. 180-186 How to Cite?
AbstractBACKGROUND: To review currently available evidence on the use of adjuvant therapy to reduce the formation of postoperative intra-abdominal adhesions. METHODS: A search on Pubmed and the Cochrane library was undertaken using the keywords "abdominal", "adhesion", "postoperative", "prevention" and "reduction". Only randomised controlled trials, prospective non-randomised controlled studies and review articles published in the English language between 1990 and 2006 were included. RESULTS: Two prospective non-randomised controlled studies and 18 randomised controlled trials were included in this review. Adjuvant therapies reviewed included pharmacological agents (streptokinase, recombinant tissue plasminogen activator, vitamin E antioxidant molecules), and mechanical barriers (hyaluronic acid barriers, oxidised regenerated cellulose barriers, nanofibrous barriers and collagen foils). Hyaluronate/carboxymethylcellulose-based bioresorbable membrane (Seprafilm) appeared to be the most efficacious in reducing adhesion formation as well as decreasing the incidence of adhesion obstruction requiring reoperation in clinical studies. Drawbacks to the use of Seprafilm include high cost and complications such as haemorrhage and poor wound healing. CONCLUSIONS: Only a limited number of adjuvant treatment methods are currently available for the reduction of postoperative adhesions. Seprafilm has been proven to be the efficacious method to reduce adhesions. Investigations into the novel therapies are showing promising results in experimental studies and clinical studies before their wider application. [Asian J Surg 2009;32(3): 180-6] © 2009 Elsevier. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84358
ISSN
2015 Impact Factor: 0.912
2015 SCImago Journal Rankings: 0.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, JPYen_HK
dc.contributor.authorTsang, HHLen_HK
dc.contributor.authorCheung, JJCen_HK
dc.contributor.authorYu, HHYen_HK
dc.contributor.authorLeung, GKKen_HK
dc.contributor.authorLaw, WLen_HK
dc.date.accessioned2010-09-06T08:52:00Z-
dc.date.available2010-09-06T08:52:00Z-
dc.date.issued2009en_HK
dc.identifier.citationAsian Journal Of Surgery, 2009, v. 32 n. 3, p. 180-186en_HK
dc.identifier.issn1015-9584en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84358-
dc.description.abstractBACKGROUND: To review currently available evidence on the use of adjuvant therapy to reduce the formation of postoperative intra-abdominal adhesions. METHODS: A search on Pubmed and the Cochrane library was undertaken using the keywords "abdominal", "adhesion", "postoperative", "prevention" and "reduction". Only randomised controlled trials, prospective non-randomised controlled studies and review articles published in the English language between 1990 and 2006 were included. RESULTS: Two prospective non-randomised controlled studies and 18 randomised controlled trials were included in this review. Adjuvant therapies reviewed included pharmacological agents (streptokinase, recombinant tissue plasminogen activator, vitamin E antioxidant molecules), and mechanical barriers (hyaluronic acid barriers, oxidised regenerated cellulose barriers, nanofibrous barriers and collagen foils). Hyaluronate/carboxymethylcellulose-based bioresorbable membrane (Seprafilm) appeared to be the most efficacious in reducing adhesion formation as well as decreasing the incidence of adhesion obstruction requiring reoperation in clinical studies. Drawbacks to the use of Seprafilm include high cost and complications such as haemorrhage and poor wound healing. CONCLUSIONS: Only a limited number of adjuvant treatment methods are currently available for the reduction of postoperative adhesions. Seprafilm has been proven to be the efficacious method to reduce adhesions. Investigations into the novel therapies are showing promising results in experimental studies and clinical studies before their wider application. [Asian J Surg 2009;32(3): 180-6] © 2009 Elsevier. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier (Singapore) Pte Ltd, Hong Kong Branch. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#descriptionen_HK
dc.relation.ispartofAsian Journal of Surgeryen_HK
dc.subjectAbdominalen_HK
dc.subjectAdhesionen_HK
dc.subjectPostoperativeen_HK
dc.subjectPreventionen_HK
dc.subjectReductionen_HK
dc.titleAdjuvant therapy for the reduction of postoperative intra-abdominal adhesion formationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1015-9584&volume=32&issue=3&spage=180&epage=186&date=2009&atitle=Adjuvant+therapy+for+the+reduction+of+postoperative+intra-abdominal+adhesion+formationen_HK
dc.identifier.emailCheung, JPY: jcheung98@hotmail.comen_HK
dc.identifier.emailLeung, GKK: gkkleung@hku.hken_HK
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_HK
dc.identifier.authorityCheung, JPY=rp01685en_HK
dc.identifier.authorityLeung, GKK=rp00522en_HK
dc.identifier.authorityLaw, WL=rp00436en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1015-9584(09)60392-4en_HK
dc.identifier.pmid19656760-
dc.identifier.scopuseid_2-s2.0-70349286818en_HK
dc.identifier.hkuros162301en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349286818&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue3en_HK
dc.identifier.spage180en_HK
dc.identifier.epage186en_HK
dc.identifier.isiWOS:000269556600010-
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridCheung, JPY=24554121300en_HK
dc.identifier.scopusauthoridTsang, HHL=36795173400en_HK
dc.identifier.scopusauthoridCheung, JJC=36448199500en_HK
dc.identifier.scopusauthoridYu, HHY=7405855517en_HK
dc.identifier.scopusauthoridLeung, GKK=35965118200en_HK
dc.identifier.scopusauthoridLaw, WL=7103147867en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats