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Article: Novel endothelial cell markers in hepatocellular carcinoma

TitleNovel endothelial cell markers in hepatocellular carcinoma
Authors
KeywordsAngiogenesis
Endothelial cell
HCC
Microarray
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/
Citation
Modern Pathology, 2004, v. 17 n. 10, p. 1198-1210 How to Cite?
AbstractHepatocellular carcinoma is characterized by hypervascularity and a propensity for vascular invasion. Detailed analysis of complementary DNA (cDNA) microarray global gene expression data and further validation on a smaller independent sample set by reverse transcription-polymerase chain reaction established the presence of two endothelial gene clusters in hepatocellular carcinoma. Cluster I, consists of 20 cDNA clones, representing 15 unique genes. Cluster II consists of nine unique genes. The expression of the cluster I genes appeared to be significantly upregulated in hepatocellular carcinoma compared with normal liver, cirrhotic liver, or nontumor liver tissues adjacent to the hepatocellular carcinoma. The pattern of gene expression of cluster I genes correlated positively with the 'proliferation gene cluster' and 'stromal cells cluster 2'. Expression of cluster II genes, in contrast, was not significantly different between hepatocellular carcinoma and non-neoplastic liver tissues. Studies conducted to localize the protein products of these genes by immunohistochemical staining of tissue arrays with up to 350 cores of tissues, and by in situ hybridization led to the discovery of novel sinusoidal endothelial cell markers in hepatocellular carcinoma: podocalyxin-like and regulator of G protein signaling-5. Our results underscore fundamental differences not only between neoplastic vs non-neoplastic liver cells but also between the hepatic sinusoidal endothelium of hepatocellular carcinoma and normal liver.
Persistent Identifierhttp://hdl.handle.net/10722/84332
ISSN
2015 Impact Factor: 5.485
2015 SCImago Journal Rankings: 2.803
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Xen_HK
dc.contributor.authorHiggins, Jen_HK
dc.contributor.authorCheung, STen_HK
dc.contributor.authorLi, Ren_HK
dc.contributor.authorMason, Ven_HK
dc.contributor.authorMontgomery, Ken_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorVan De Rijn, Men_HK
dc.contributor.authorSo, Sen_HK
dc.date.accessioned2010-09-06T08:51:41Z-
dc.date.available2010-09-06T08:51:41Z-
dc.date.issued2004en_HK
dc.identifier.citationModern Pathology, 2004, v. 17 n. 10, p. 1198-1210en_HK
dc.identifier.issn0893-3952en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84332-
dc.description.abstractHepatocellular carcinoma is characterized by hypervascularity and a propensity for vascular invasion. Detailed analysis of complementary DNA (cDNA) microarray global gene expression data and further validation on a smaller independent sample set by reverse transcription-polymerase chain reaction established the presence of two endothelial gene clusters in hepatocellular carcinoma. Cluster I, consists of 20 cDNA clones, representing 15 unique genes. Cluster II consists of nine unique genes. The expression of the cluster I genes appeared to be significantly upregulated in hepatocellular carcinoma compared with normal liver, cirrhotic liver, or nontumor liver tissues adjacent to the hepatocellular carcinoma. The pattern of gene expression of cluster I genes correlated positively with the 'proliferation gene cluster' and 'stromal cells cluster 2'. Expression of cluster II genes, in contrast, was not significantly different between hepatocellular carcinoma and non-neoplastic liver tissues. Studies conducted to localize the protein products of these genes by immunohistochemical staining of tissue arrays with up to 350 cores of tissues, and by in situ hybridization led to the discovery of novel sinusoidal endothelial cell markers in hepatocellular carcinoma: podocalyxin-like and regulator of G protein signaling-5. Our results underscore fundamental differences not only between neoplastic vs non-neoplastic liver cells but also between the hepatic sinusoidal endothelium of hepatocellular carcinoma and normal liver.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/en_HK
dc.relation.ispartofModern Pathologyen_HK
dc.subjectAngiogenesisen_HK
dc.subjectEndothelial cellen_HK
dc.subjectHCCen_HK
dc.subjectMicroarrayen_HK
dc.titleNovel endothelial cell markers in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0893-3952&volume=17&issue=10&spage=1198&epage=1210&date=2004&atitle=Novel+endothelial+cell+markers+in+hepatocellular+carcinomaen_HK
dc.identifier.emailCheung, ST: stcheung@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityCheung, ST=rp00457en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/modpathol.3800167en_HK
dc.identifier.pmid15154008-
dc.identifier.scopuseid_2-s2.0-4744347276en_HK
dc.identifier.hkuros96812en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4744347276&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1198en_HK
dc.identifier.epage1210en_HK
dc.identifier.isiWOS:000224094600004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChen, X=8978110800en_HK
dc.identifier.scopusauthoridHiggins, J=25642411200en_HK
dc.identifier.scopusauthoridCheung, ST=7202473497en_HK
dc.identifier.scopusauthoridLi, R=7404723086en_HK
dc.identifier.scopusauthoridMason, V=7004690511en_HK
dc.identifier.scopusauthoridMontgomery, K=7102499348en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridVan De Rijn, M=7005571510en_HK
dc.identifier.scopusauthoridSo, S=35238727400en_HK

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