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Article: Lipoprotein (a) level and mortality in patients with critical lower limb ischaemia

TitleLipoprotein (a) level and mortality in patients with critical lower limb ischaemia
Authors
KeywordsLipoprotein (a)
Peripheral vascular diseases
Survival
Issue Date2001
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvs
Citation
European Journal Of Vascular And Endovascular Surgery, 2001, v. 22 n. 2, p. 124-129 How to Cite?
AbstractObjective: to investigate if serum lipoprotein (a) level is a predictor of survival in patients with lower limb atherosclerotic occlusive disease. Design: prospective follow up study. Methods: demographic, biochemical and disease variables were collected prospectively in 441 patients with lower limb arterial occlusive disease. Survival data were obtained at a mean follow up of 44 months, and significant risk factors identified by the life table method and multivariate Cox regression analysis. Results: the cumulative survival for all patients at three and five years was 79% and 63%. Lipoprotein (a) level was the only significant independent biochemical predictor for all deaths and cardiorespiratory deaths on multivariate analysis, along with age, diabetes mellitus, renal impairment, cardiac diseases and major amputation. An elevated Lipoprotein(a) level of >24 mg/dl incurred a 107% and 45% increase in mortality at three and five years respectively. The higher mortality associated with elevated Lipoprotein (a) was particularly evident in patients with critical ischemia, in whom three and five year survival was reduced from 85% to 63% and 67% to 53% (p = 0.0064). In claudicants a survival discrepancy was manifested only after five years (73% vs 62%), and the overall association did not reach statistic significance (p = 0.52). Conclusions: lipoprotein (a) level is a reliable biochemical marker for survival in patients with critical ischemia where traditional atherosclerosis risk factors were prevalent.
Persistent Identifierhttp://hdl.handle.net/10722/84326
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.723
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, SWKen_HK
dc.contributor.authorTing, ACWen_HK
dc.date.accessioned2010-09-06T08:51:37Z-
dc.date.available2010-09-06T08:51:37Z-
dc.date.issued2001en_HK
dc.identifier.citationEuropean Journal Of Vascular And Endovascular Surgery, 2001, v. 22 n. 2, p. 124-129en_HK
dc.identifier.issn1078-5884en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84326-
dc.description.abstractObjective: to investigate if serum lipoprotein (a) level is a predictor of survival in patients with lower limb atherosclerotic occlusive disease. Design: prospective follow up study. Methods: demographic, biochemical and disease variables were collected prospectively in 441 patients with lower limb arterial occlusive disease. Survival data were obtained at a mean follow up of 44 months, and significant risk factors identified by the life table method and multivariate Cox regression analysis. Results: the cumulative survival for all patients at three and five years was 79% and 63%. Lipoprotein (a) level was the only significant independent biochemical predictor for all deaths and cardiorespiratory deaths on multivariate analysis, along with age, diabetes mellitus, renal impairment, cardiac diseases and major amputation. An elevated Lipoprotein(a) level of >24 mg/dl incurred a 107% and 45% increase in mortality at three and five years respectively. The higher mortality associated with elevated Lipoprotein (a) was particularly evident in patients with critical ischemia, in whom three and five year survival was reduced from 85% to 63% and 67% to 53% (p = 0.0064). In claudicants a survival discrepancy was manifested only after five years (73% vs 62%), and the overall association did not reach statistic significance (p = 0.52). Conclusions: lipoprotein (a) level is a reliable biochemical marker for survival in patients with critical ischemia where traditional atherosclerosis risk factors were prevalent.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvsen_HK
dc.relation.ispartofEuropean Journal of Vascular and Endovascular Surgeryen_HK
dc.subjectLipoprotein (a)en_HK
dc.subjectPeripheral vascular diseasesen_HK
dc.subjectSurvivalen_HK
dc.titleLipoprotein (a) level and mortality in patients with critical lower limb ischaemiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1078-5884&volume=22&spage=124&epage=129&date=2001&atitle=Lipoprotein(a)+level+and+mortality+in+patients+with+critical+lower+limb+ischaemiaen_HK
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hken_HK
dc.identifier.authorityCheng, SWK=rp00374en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/ejvs.2001.1431en_HK
dc.identifier.pmid11472044-
dc.identifier.scopuseid_2-s2.0-0034904348en_HK
dc.identifier.hkuros68577en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034904348&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue2en_HK
dc.identifier.spage124en_HK
dc.identifier.epage129en_HK
dc.identifier.isiWOS:000170379700004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheng, SWK=7404684779en_HK
dc.identifier.scopusauthoridTing, ACW=7102858552en_HK

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