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Article: Abdominoperineal resection is associated with poor oncological outcome

TitleAbdominoperineal resection is associated with poor oncological outcome
Authors
Issue Date2004
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uk
Citation
British Journal Of Surgery, 2004, v. 91 n. 11, p. 1493-1499 How to Cite?
AbstractBackground: The aim of this study was to compare the operative results and oncological outcomes of patients who had mid or distal rectal cancer treated by abdominoperineal resection (APR) with those treated without sphincter ablation (non-APR). Methods: Five hundred and four consecutive patients (308 men and 196 women) with rectal cancer within 12 cm from the anal verge underwent radical resection with curative intent. Sharp mesorectal dissection was used. Operative results and long-term outcomes were compared between those treated by APR and those by non-APR. Results: Sixty-nine patients had APR and 435 patients were treated with radical resection without perineal resection (anterior resection, 419; Hartmann's operation, 16). The overall operative mortality and morbidity rates were 1-6 and 31-0 per cent respectively. Age, sex, duration of surgery, blood loss, duration of hospital stay, operative mortality and overall morbidity were similar in the two groups. Local recurrence was more frequent after curative APR than after non-APR (23 versus 10-2 per cent at 5 years; P = 0.010). Five-year cancer-specific survival rates after APR and non-APR were 60 and 74.0 per cent respectively (P = 0.006). APR was an independent factor for poor cancer-specific survival in multivariate analysis. Conclusion: Although postoperative mortality and morbidity rates were similar in patients with or without sphincter ablation, local control and survival were worse in those treated by APR.
Persistent Identifierhttp://hdl.handle.net/10722/84325
ISSN
2015 Impact Factor: 5.596
2015 SCImago Journal Rankings: 2.966
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLaw, WLen_HK
dc.contributor.authorChu, KWen_HK
dc.date.accessioned2010-09-06T08:51:36Z-
dc.date.available2010-09-06T08:51:36Z-
dc.date.issued2004en_HK
dc.identifier.citationBritish Journal Of Surgery, 2004, v. 91 n. 11, p. 1493-1499en_HK
dc.identifier.issn0007-1323en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84325-
dc.description.abstractBackground: The aim of this study was to compare the operative results and oncological outcomes of patients who had mid or distal rectal cancer treated by abdominoperineal resection (APR) with those treated without sphincter ablation (non-APR). Methods: Five hundred and four consecutive patients (308 men and 196 women) with rectal cancer within 12 cm from the anal verge underwent radical resection with curative intent. Sharp mesorectal dissection was used. Operative results and long-term outcomes were compared between those treated by APR and those by non-APR. Results: Sixty-nine patients had APR and 435 patients were treated with radical resection without perineal resection (anterior resection, 419; Hartmann's operation, 16). The overall operative mortality and morbidity rates were 1-6 and 31-0 per cent respectively. Age, sex, duration of surgery, blood loss, duration of hospital stay, operative mortality and overall morbidity were similar in the two groups. Local recurrence was more frequent after curative APR than after non-APR (23 versus 10-2 per cent at 5 years; P = 0.010). Five-year cancer-specific survival rates after APR and non-APR were 60 and 74.0 per cent respectively (P = 0.006). APR was an independent factor for poor cancer-specific survival in multivariate analysis. Conclusion: Although postoperative mortality and morbidity rates were similar in patients with or without sphincter ablation, local control and survival were worse in those treated by APR.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uken_HK
dc.relation.ispartofBritish Journal of Surgeryen_HK
dc.rightsBritish Journal of Surgery. Copyright © John Wiley & Sons Ltd.en_HK
dc.titleAbdominoperineal resection is associated with poor oncological outcomeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1323&volume=91&issue=11&spage=1493&epage=1499&date=2004&atitle=Abdominoperineal+resection+is+associated+with+poor+oncological+outcomeen_HK
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_HK
dc.identifier.authorityLaw, WL=rp00436en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/bjs.4723en_HK
dc.identifier.pmid15455362-
dc.identifier.scopuseid_2-s2.0-8744303550en_HK
dc.identifier.hkuros97085en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-8744303550&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume91en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1493en_HK
dc.identifier.epage1499en_HK
dc.identifier.isiWOS:000225173100017-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLaw, WL=7103147867en_HK
dc.identifier.scopusauthoridChu, KW=7402453653en_HK

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