File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Sustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma

TitleSustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma
Authors
KeywordsCancer screening
EBV
NPC
Serology
Tumour marker
Issue Date2007
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal Of Cancer, 2007, v. 96 n. 4, p. 623-630 How to Cite?
AbstractWe have monitored Epstein-Barr virus (EBV) IgA antibody levels of 39 nasopharyngeal carcinoma (NPC) cases for up to 15 years before clinical onset of NPC, and assessed preclinical serologic status of another 68 cases. Our results identify a serologic window preceding diagnosis when antibody levels are raised and sustained. This window can persist for as long as 10 years, with a mean duration estimated to as 37±28 months. Ninety-seven of these 107 NPC cases exhibited such a window. Cases that did not may reflect individual antibody response to EBV. Serologic screening at enrollment identified those cases who had already entered the window and became clinically manifested earlier (median=28 months) than those who entered the window after enrollment (median=90 months). The former account for 19 of 21 cases diagnosed within 2 years of screening. Nasopharyngeal carcinoma risk levels among seropositive subjects were also highest during this period. Both prediction rates and risk levels declined thereafter; cases detected at later times were composed of increasing proportions of individuals who entered the serological window after screening. Our findings establish EBV antibody as an early marker of NPC and suggest that repeated screening to monitor cases as they enter this window has considerable predictive value, with practical consequences for cancer treatment. © 2007 Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/84311
ISSN
2015 Impact Factor: 5.569
2015 SCImago Journal Rankings: 2.939
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJi, MFen_HK
dc.contributor.authorWang, DKen_HK
dc.contributor.authorYu, YLen_HK
dc.contributor.authorGuo, YQen_HK
dc.contributor.authorLiang, JSen_HK
dc.contributor.authorCheng, WMen_HK
dc.contributor.authorZong, YSen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorNg, SPen_HK
dc.contributor.authorWei, WIen_HK
dc.contributor.authorChua, DTTen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorNg, MHen_HK
dc.date.accessioned2010-09-06T08:51:26Z-
dc.date.available2010-09-06T08:51:26Z-
dc.date.issued2007en_HK
dc.identifier.citationBritish Journal Of Cancer, 2007, v. 96 n. 4, p. 623-630en_HK
dc.identifier.issn0007-0920en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84311-
dc.description.abstractWe have monitored Epstein-Barr virus (EBV) IgA antibody levels of 39 nasopharyngeal carcinoma (NPC) cases for up to 15 years before clinical onset of NPC, and assessed preclinical serologic status of another 68 cases. Our results identify a serologic window preceding diagnosis when antibody levels are raised and sustained. This window can persist for as long as 10 years, with a mean duration estimated to as 37±28 months. Ninety-seven of these 107 NPC cases exhibited such a window. Cases that did not may reflect individual antibody response to EBV. Serologic screening at enrollment identified those cases who had already entered the window and became clinically manifested earlier (median=28 months) than those who entered the window after enrollment (median=90 months). The former account for 19 of 21 cases diagnosed within 2 years of screening. Nasopharyngeal carcinoma risk levels among seropositive subjects were also highest during this period. Both prediction rates and risk levels declined thereafter; cases detected at later times were composed of increasing proportions of individuals who entered the serological window after screening. Our findings establish EBV antibody as an early marker of NPC and suggest that repeated screening to monitor cases as they enter this window has considerable predictive value, with practical consequences for cancer treatment. © 2007 Cancer Research.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjcen_HK
dc.relation.ispartofBritish Journal of Canceren_HK
dc.subjectCancer screeningen_HK
dc.subjectEBVen_HK
dc.subjectNPCen_HK
dc.subjectSerologyen_HK
dc.subjectTumour markeren_HK
dc.titleSustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0920&volume=96&spage=623&epage=630&date=2007&atitle=Sustained+elevation+of+Epstein-Barr+virus+antibody+levels+preceding+clinical+onset+of+nasopharyngeal+carcinoma.en_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.emailChua, DTT: dttchua@hkucc.hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.identifier.authorityChua, DTT=rp00415en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.bjc.6603609en_HK
dc.identifier.pmid17285127en_HK
dc.identifier.scopuseid_2-s2.0-33847190647en_HK
dc.identifier.hkuros134162en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33847190647&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume96en_HK
dc.identifier.issue4en_HK
dc.identifier.spage623en_HK
dc.identifier.epage630en_HK
dc.identifier.isiWOS:000244715300013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridJi, MF=8229413000en_HK
dc.identifier.scopusauthoridWang, DK=7407072857en_HK
dc.identifier.scopusauthoridYu, YL=35101080100en_HK
dc.identifier.scopusauthoridGuo, YQ=26661496700en_HK
dc.identifier.scopusauthoridLiang, JS=16145038900en_HK
dc.identifier.scopusauthoridCheng, WM=37361044000en_HK
dc.identifier.scopusauthoridZong, YS=7005203474en_HK
dc.identifier.scopusauthoridChan, KH=35338760600en_HK
dc.identifier.scopusauthoridNg, SP=8862966400en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.scopusauthoridChua, DTT=7006773480en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridNg, MH=7202076421en_HK
dc.identifier.citeulike1091724-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats