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Article: Quantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinoma

TitleQuantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinoma
Authors
Issue Date2003
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2003, v. 63 n. 12, p. 3121-3126 How to Cite?
AbstractRecent studies have suggested that serum levels of vascular endothelial growth factor (VEGF) may provide useful prognostic information in patients with various types of cancers. However, there has been a debate on whether serum VEGF level is a true reflection of tumor angiogenic activity in cancer patients. This debate originates from the finding that most VEGF in the serum is released from platelets during clotting. It has been postulated that platelet may serve the role of storage for circulating VEGF derived from the tumors. We conducted a study to clarify whether the platelet load of VEGF in the circulation correlates with tumor expression of VEGF. We measured quantitatively the serum VEGF 165 levels and tumor cytosolic VEGF 165 concentration by an ELISA and tumor VEGF 165 mRNA by real-time quantitative reverse transcription-PCR in 60 patients with hepatocellular carcinoma. Serum VEGF 165 levels correlated significantly with platelet counts (r = 0.662, P < 0.001). When corrected for platelet count, serum VEGF 165/platelet correlated significantly with tumor cytosolic VEGF 165 concentration (r = 0.447, P = 0.006), which in turn correlated with VEGF 165 mRNA expression in the tumors (r = 0.315, P = 0.020). Advancing tumor stage was associated with a significant increase in tumor cytosolic VEGF 165 concentration (P = 0.006), tumor VEGF 165 mRNA expression (P = 0.012), serum VEGF 165/platelet (P = 0.001), and serum VEGF 165 levels (P = 0.003). In conclusion, our data showed that the platelet load of VEGF in the circulation correlated positively with tumor VEGF expression. This study provides strong evidence that supports the use of serum VEGF level as an indirect estimate of tumor VEGF expression.
Persistent Identifierhttp://hdl.handle.net/10722/84305
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorLau, CPYen_HK
dc.contributor.authorCheung, STen_HK
dc.contributor.authorYu, WCen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:51:22Z-
dc.date.available2010-09-06T08:51:22Z-
dc.date.issued2003en_HK
dc.identifier.citationCancer Research, 2003, v. 63 n. 12, p. 3121-3126en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84305-
dc.description.abstractRecent studies have suggested that serum levels of vascular endothelial growth factor (VEGF) may provide useful prognostic information in patients with various types of cancers. However, there has been a debate on whether serum VEGF level is a true reflection of tumor angiogenic activity in cancer patients. This debate originates from the finding that most VEGF in the serum is released from platelets during clotting. It has been postulated that platelet may serve the role of storage for circulating VEGF derived from the tumors. We conducted a study to clarify whether the platelet load of VEGF in the circulation correlates with tumor expression of VEGF. We measured quantitatively the serum VEGF 165 levels and tumor cytosolic VEGF 165 concentration by an ELISA and tumor VEGF 165 mRNA by real-time quantitative reverse transcription-PCR in 60 patients with hepatocellular carcinoma. Serum VEGF 165 levels correlated significantly with platelet counts (r = 0.662, P < 0.001). When corrected for platelet count, serum VEGF 165/platelet correlated significantly with tumor cytosolic VEGF 165 concentration (r = 0.447, P = 0.006), which in turn correlated with VEGF 165 mRNA expression in the tumors (r = 0.315, P = 0.020). Advancing tumor stage was associated with a significant increase in tumor cytosolic VEGF 165 concentration (P = 0.006), tumor VEGF 165 mRNA expression (P = 0.012), serum VEGF 165/platelet (P = 0.001), and serum VEGF 165 levels (P = 0.003). In conclusion, our data showed that the platelet load of VEGF in the circulation correlated positively with tumor VEGF expression. This study provides strong evidence that supports the use of serum VEGF level as an indirect estimate of tumor VEGF expression.en_HK
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.titleQuantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-5472&volume=63&spage=3121&epage=3126&date=2003&atitle=Quantitative+correlation+of+serum+levels+and+tumor+expression+of+vascular+endothelial+growth+factor+in+patients+with+hepatocellular+carcinomaen_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailCheung, ST: stcheung@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityCheung, ST=rp00457en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12810638-
dc.identifier.scopuseid_2-s2.0-0037731710en_HK
dc.identifier.hkuros79196en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037731710&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume63en_HK
dc.identifier.issue12en_HK
dc.identifier.spage3121en_HK
dc.identifier.epage3126en_HK
dc.identifier.isiWOS:000183586800021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridLau, CPY=8086563300en_HK
dc.identifier.scopusauthoridCheung, ST=7202473497en_HK
dc.identifier.scopusauthoridYu, WC=24490445800en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

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