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Article: MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties

TitleMicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties
Authors
KeywordsCarcinogenesis
Hepatocellular carcinoma
Hippo signaling
MicroRNA
YAP
Issue Date2010
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2010, v. 394 n. 3, p. 623-627 How to Cite?
AbstractHepatocellular carcinoma (HCC) is a malignant form of liver cancer that ranks the second leading cause of cancer-related deaths in China and many Asia regions. The dismal outcome reflects the need for a better understanding of the transcriptional control of oncogenic signaling pathway. Our recent findings have identified yes-associated protein (YAP) is a potent oncogenic driver and independent prognostic risk factor of HCC. The present study aims to elucidate the transcriptional regulation of YAP targeted by microRNA (miRNA). miR-375 is a putative target and was found significantly down-regulated in the tumor versus adjacent non-tumor tissues of HCC patients (n = 48). As determined by luciferase reporter assay, we found ectopic expression of miR-375 could diminish the transcriptional activity of YAP. Furthermore, immunoblotting revealed miR-375 suppressed endogenous YAP protein level. Functional assays showed that miR-375 was able to inhibit proliferation and invasion of HCC cells. Conclusion: miR-375 is an important regulator of YAP oncogene, implicating a potential therapeutic role in HCC treatment. © 2010 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84300
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong University National University of Singapore
NMRC research grant
Funding Information:

The study was supported by the Hong Kong University National University of Singapore and NMRC research grant The work was conducted by A.L. for partial fulfillment of her Ph D. study. The authors acknowledged the provision of miR-122 construct from Dr Julja Burchard of SIRNA, Inc. (USA)

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, AMen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorLuk, JMen_HK
dc.date.accessioned2010-09-06T08:51:19Z-
dc.date.available2010-09-06T08:51:19Z-
dc.date.issued2010en_HK
dc.identifier.citationBiochemical And Biophysical Research Communications, 2010, v. 394 n. 3, p. 623-627en_HK
dc.identifier.issn0006-291Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/84300-
dc.description.abstractHepatocellular carcinoma (HCC) is a malignant form of liver cancer that ranks the second leading cause of cancer-related deaths in China and many Asia regions. The dismal outcome reflects the need for a better understanding of the transcriptional control of oncogenic signaling pathway. Our recent findings have identified yes-associated protein (YAP) is a potent oncogenic driver and independent prognostic risk factor of HCC. The present study aims to elucidate the transcriptional regulation of YAP targeted by microRNA (miRNA). miR-375 is a putative target and was found significantly down-regulated in the tumor versus adjacent non-tumor tissues of HCC patients (n = 48). As determined by luciferase reporter assay, we found ectopic expression of miR-375 could diminish the transcriptional activity of YAP. Furthermore, immunoblotting revealed miR-375 suppressed endogenous YAP protein level. Functional assays showed that miR-375 was able to inhibit proliferation and invasion of HCC cells. Conclusion: miR-375 is an important regulator of YAP oncogene, implicating a potential therapeutic role in HCC treatment. © 2010 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_HK
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_HK
dc.subjectCarcinogenesisen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectHippo signalingen_HK
dc.subjectMicroRNAen_HK
dc.subjectYAPen_HK
dc.subject.meshCarcinoma, Hepatocellular - genetics - pathology - therapy-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshLiver Neoplasms - genetics - pathology - therapy-
dc.subject.meshMicroRNAs - genetics - metabolism-
dc.subject.meshNuclear Proteins - genetics - metabolism-
dc.titleMicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor propertiesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-291X&volume=394&issue=3&spage=623&epage=627&date=2010&atitle=MicroRNA-375+targets+Hippo-signaling+effector+YAP+in+liver+cancer+and+inhibits+tumor+propertiesen_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbrc.2010.03.036en_HK
dc.identifier.pmid20226166-
dc.identifier.scopuseid_2-s2.0-77950626836en_HK
dc.identifier.hkuros169640en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950626836&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume394en_HK
dc.identifier.issue3en_HK
dc.identifier.spage623en_HK
dc.identifier.epage627en_HK
dc.identifier.isiWOS:000276785900033-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, AM=36134439500en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.citeulike6864711-

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