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Article: Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation

TitleApplication of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation
Authors
KeywordsCandidate genes
Neurotransmitters
Pediatric slow transit constipation
Issue Date2007
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
Citation
Journal Of Pediatric Surgery, 2007, v. 42 n. 4, p. 666-671 How to Cite?
AbstractBackground: Slow transit constipation (STC) affects up to 3% of all children and is an increasingly recognized cause of chronic constipation in children. We conducted a pilot study to investigate whether genes encoding neurotransmitters (TAC1, TAC3, VIP, NOS1) and receptors (TACR1, TACR2, TACR3, KIT) could be responsible for STC. Methods: One hundred seventeen tag single nucleotide polymorphisms (SNPs), distributed among the candidate genes, were selected from HapMap data and genotyped using Sequenom (San Diego, CA) technology in 35 affected families. Evaluation of association was performed by transmission disequilibrium test and multilocus analysis. Results: Five SNPs (rs3771863, rs4580655, rs11722288, rs4563545, and rs3782221) in the TACR1, TACR3, KIT, and NOS1 genes were found to be potentially associated with STC, although the significance of these results does not withstand correction for multiple testing. Conclusions: Our data indicate that 5 SNPs in the NOS1, TACR1, TACR3, and KIT genes could be involved in STC, especially rs3771863 in intron 1 of TACR1, which showed the highest association. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84232
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.802
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGarciaBarcelo, Men_HK
dc.contributor.authorKing, SKen_HK
dc.contributor.authorMiao, Xen_HK
dc.contributor.authorSo, Mten_HK
dc.contributor.authorHolden, WTen_HK
dc.contributor.authorMoore, JHen_HK
dc.contributor.authorSutcliffe, JRen_HK
dc.contributor.authorHutson, JMen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T08:50:31Z-
dc.date.available2010-09-06T08:50:31Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Pediatric Surgery, 2007, v. 42 n. 4, p. 666-671en_HK
dc.identifier.issn0022-3468en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84232-
dc.description.abstractBackground: Slow transit constipation (STC) affects up to 3% of all children and is an increasingly recognized cause of chronic constipation in children. We conducted a pilot study to investigate whether genes encoding neurotransmitters (TAC1, TAC3, VIP, NOS1) and receptors (TACR1, TACR2, TACR3, KIT) could be responsible for STC. Methods: One hundred seventeen tag single nucleotide polymorphisms (SNPs), distributed among the candidate genes, were selected from HapMap data and genotyped using Sequenom (San Diego, CA) technology in 35 affected families. Evaluation of association was performed by transmission disequilibrium test and multilocus analysis. Results: Five SNPs (rs3771863, rs4580655, rs11722288, rs4563545, and rs3782221) in the TACR1, TACR3, KIT, and NOS1 genes were found to be potentially associated with STC, although the significance of these results does not withstand correction for multiple testing. Conclusions: Our data indicate that 5 SNPs in the NOS1, TACR1, TACR3, and KIT genes could be involved in STC, especially rs3771863 in intron 1 of TACR1, which showed the highest association. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurgen_HK
dc.relation.ispartofJournal of Pediatric Surgeryen_HK
dc.subjectCandidate genesen_HK
dc.subjectNeurotransmittersen_HK
dc.subjectPediatric slow transit constipationen_HK
dc.titleApplication of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3468&volume=42&issue=4&spage=666&epage=671&date=2007&atitle=Application+of+HapMap+data+to+the+evaluation+of+8+candidate+genes+for+pediatric+slow+transit+constipationen_HK
dc.identifier.emailGarciaBarcelo, M: mmgarcia@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityGarciaBarcelo, M=rp00445en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jpedsurg.2006.12.014en_HK
dc.identifier.pmid17448763en_HK
dc.identifier.scopuseid_2-s2.0-34247135476en_HK
dc.identifier.hkuros126884en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247135476&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume42en_HK
dc.identifier.issue4en_HK
dc.identifier.spage666en_HK
dc.identifier.epage671en_HK
dc.identifier.isiWOS:000246470000012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGarciaBarcelo, M=6701767303en_HK
dc.identifier.scopusauthoridKing, SK=7403002710en_HK
dc.identifier.scopusauthoridMiao, X=7102585391en_HK
dc.identifier.scopusauthoridSo, Mt=8748542200en_HK
dc.identifier.scopusauthoridHolden, WT=16229808700en_HK
dc.identifier.scopusauthoridMoore, JH=7405241093en_HK
dc.identifier.scopusauthoridSutcliffe, JR=7101638757en_HK
dc.identifier.scopusauthoridHutson, JM=35253772000en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK

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