File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Chemokine receptors support infiltration of lymphocyte subpopulations in human hepatocellular carcinoma

TitleChemokine receptors support infiltration of lymphocyte subpopulations in human hepatocellular carcinoma
Authors
KeywordsChemokine receptor
Hepatocellular carcinoma
Lymphocyte
Issue Date2005
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yclim
Citation
Clinical Immunology, 2005, v. 114 n. 2, p. 174-182 How to Cite?
AbstractThe presence of lymphocyte infiltration in human hepatocellular carcinoma (HCC) is evident. However, immune regulation of lymphocytes in HCC is poorly characterized. In this study, we investigated the chemokine receptor and memory, activation and adhesion markers of major leukocyte subsets present in tumor, nontumor liver, and peripheral blood. T cells from both tumor and peritumor liver displayed high levels of activation and homing markers. CCR5 and CXCR3 were expressed in a large proportion of CD45RO +, CD69 +, CD27 +, and CD11a + T cells from tumor compared with T cells from circulation. The proportion of CCR6- and CXCR3-expressing natural killer cells (NK) and natural killer T cells (NKT) was significantly increased in the tumor and nontumor liver compared with peripheral blood. This study demonstrates the role of chemokine receptors in the recruitment of specific lymphocyte subsets to the liver in HCC and suggests the importance of these receptors in regulation of immune defense against HCC. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84202
ISSN
2015 Impact Factor: 4.034
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorPoon, RTen_HK
dc.contributor.authorHughes, Jen_HK
dc.contributor.authorFeng, Xen_HK
dc.contributor.authorYu, WCen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:50:10Z-
dc.date.available2010-09-06T08:50:10Z-
dc.date.issued2005en_HK
dc.identifier.citationClinical Immunology, 2005, v. 114 n. 2, p. 174-182en_HK
dc.identifier.issn1521-6616en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84202-
dc.description.abstractThe presence of lymphocyte infiltration in human hepatocellular carcinoma (HCC) is evident. However, immune regulation of lymphocytes in HCC is poorly characterized. In this study, we investigated the chemokine receptor and memory, activation and adhesion markers of major leukocyte subsets present in tumor, nontumor liver, and peripheral blood. T cells from both tumor and peritumor liver displayed high levels of activation and homing markers. CCR5 and CXCR3 were expressed in a large proportion of CD45RO +, CD69 +, CD27 +, and CD11a + T cells from tumor compared with T cells from circulation. The proportion of CCR6- and CXCR3-expressing natural killer cells (NK) and natural killer T cells (NKT) was significantly increased in the tumor and nontumor liver compared with peripheral blood. This study demonstrates the role of chemokine receptors in the recruitment of specific lymphocyte subsets to the liver in HCC and suggests the importance of these receptors in regulation of immune defense against HCC. © 2004 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yclimen_HK
dc.relation.ispartofClinical Immunologyen_HK
dc.subjectChemokine receptoren_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectLymphocyteen_HK
dc.titleChemokine receptors support infiltration of lymphocyte subpopulations in human hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1521-6616&volume=114&issue=2&spage=174&epage=182&date=2005&atitle=Chemokine+receptors+support+infiltration+of+lymphocyte+subpopulations+in+human+hepatocellular+carcinomaen_HK
dc.identifier.emailPoon, RT: poontp@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityPoon, RT=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.clim.2004.10.006en_HK
dc.identifier.pmid15639651-
dc.identifier.scopuseid_2-s2.0-11444252814en_HK
dc.identifier.hkuros97118en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-11444252814&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume114en_HK
dc.identifier.issue2en_HK
dc.identifier.spage174en_HK
dc.identifier.epage182en_HK
dc.identifier.isiWOS:000226440700010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, Y=14627533300en_HK
dc.identifier.scopusauthoridPoon, RT=7103097223en_HK
dc.identifier.scopusauthoridHughes, J=7404719934en_HK
dc.identifier.scopusauthoridFeng, X=55224961700en_HK
dc.identifier.scopusauthoridYu, WC=37022285400en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats