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Article: Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy

TitlePreoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy
Authors
KeywordsBiomarker
Circulating nucleic acid
Liver cancer
Plasma RNA
Prognosis
Issue Date2006
PublisherNeoplasia Press. The Journal's web site is located at http://www.neoplasia.org
Citation
Neoplasia, 2006, v. 8 n. 9, p. 696-701.a-b How to Cite?
AbstractBACKGROUND: We have previously reported that tissue expression levels of transcript AA454543 in hepatocellular carcinoma (HCC) are significantly higher than those of normal livers, livers with cirrhosis, and livers with hepatitis. In addition, a higher level of transcript AA454543 in tumor tissues is associated with poor prognosis. We aim to examine whether quantitative measurement of preoperative plasma transcript AA454543 can provide similar prognostic information. PATIENTS AND METHODS: Blood samples were obtained from 84 HCC patients before surgery. Real-time quantitative reverse transcription-polymerase chain reaction, using TaqMan system, was employed to measure plasma transcript AA454543 and α-fetoprotein (AFP) RNA levels. We assessed their prediction power in prognosis using univariate and multivariate analyses. RESULTS: High plasma transcript AA454543 RNA levels were associated with poor overall survival (log-rank test, P < .01). Patients with different plasma AFP RNA levels revealed no difference in overall survival (log-rank test, P = .88). By multivariate Cox regression analysis, plasma transcript AA454543 RNA level (hazard ratio = 4.8, P < .01) and tumor stage (hazard ratio = 1.7, P < .01) were determined to be independent risk factors for the prediction of overall survival. CONCLUSION: Preoperative plasma transcript AA454543 RNA level can provide prognostic information for HCC patients receiving curative partial hepatectomy. Copyright © 2006 Neoplasia Press, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84194
ISSN
2014 Impact Factor: 4.252
2015 SCImago Journal Rankings: 2.541
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, STen_HK
dc.contributor.authorLiu, CLen_HK
dc.contributor.authorChow, JPHen_HK
dc.contributor.authorLee, YTen_HK
dc.contributor.authorIp, YCen_HK
dc.contributor.authorHo, JCYen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:50:04Z-
dc.date.available2010-09-06T08:50:04Z-
dc.date.issued2006en_HK
dc.identifier.citationNeoplasia, 2006, v. 8 n. 9, p. 696-701.a-ben_HK
dc.identifier.issn1522-8002en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84194-
dc.description.abstractBACKGROUND: We have previously reported that tissue expression levels of transcript AA454543 in hepatocellular carcinoma (HCC) are significantly higher than those of normal livers, livers with cirrhosis, and livers with hepatitis. In addition, a higher level of transcript AA454543 in tumor tissues is associated with poor prognosis. We aim to examine whether quantitative measurement of preoperative plasma transcript AA454543 can provide similar prognostic information. PATIENTS AND METHODS: Blood samples were obtained from 84 HCC patients before surgery. Real-time quantitative reverse transcription-polymerase chain reaction, using TaqMan system, was employed to measure plasma transcript AA454543 and α-fetoprotein (AFP) RNA levels. We assessed their prediction power in prognosis using univariate and multivariate analyses. RESULTS: High plasma transcript AA454543 RNA levels were associated with poor overall survival (log-rank test, P < .01). Patients with different plasma AFP RNA levels revealed no difference in overall survival (log-rank test, P = .88). By multivariate Cox regression analysis, plasma transcript AA454543 RNA level (hazard ratio = 4.8, P < .01) and tumor stage (hazard ratio = 1.7, P < .01) were determined to be independent risk factors for the prediction of overall survival. CONCLUSION: Preoperative plasma transcript AA454543 RNA level can provide prognostic information for HCC patients receiving curative partial hepatectomy. Copyright © 2006 Neoplasia Press, Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNeoplasia Press. The Journal's web site is located at http://www.neoplasia.orgen_HK
dc.relation.ispartofNeoplasiaen_HK
dc.subjectBiomarkeren_HK
dc.subjectCirculating nucleic aciden_HK
dc.subjectLiver canceren_HK
dc.subjectPlasma RNAen_HK
dc.subjectPrognosisen_HK
dc.titlePreoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1522-8002&volume=8&issue=9&spage=696&epage=701&date=2006&atitle=Preoperative+plasma+transcript+AA454543+level+is+an+independent+prognostic+factor+for+hepatocellular+carcinoma+after+partial+hepatectomyen_HK
dc.identifier.emailSiu, TC: stcheung@hkucc.hku.hken_HK
dc.identifier.authoritySiu, TC=rp00457en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1593/neo.06181en_HK
dc.identifier.pmid16984726-
dc.identifier.scopuseid_2-s2.0-33749079701en_HK
dc.identifier.hkuros124163en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33749079701&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue9en_HK
dc.identifier.spage696en_HK
dc.identifier.epage701.aen_HK
dc.identifier.isiWOS:000240460900001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSiu, TC=7202473497en_HK
dc.identifier.scopusauthoridChi, LL=7409789712en_HK
dc.identifier.scopusauthoridChow, JPH=49761108400en_HK
dc.identifier.scopusauthoridYuk, TL=14632582400en_HK
dc.identifier.scopusauthoridYing, CI=14039827000en_HK
dc.identifier.scopusauthoridHo, JCY=7402650284en_HK
dc.identifier.scopusauthoridSheung, TF=6506234707en_HK
dc.identifier.citeulike844668-

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