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Article: Radial clearance in resection of hypopharyngeal cancer: An independent prognostic factor

TitleRadial clearance in resection of hypopharyngeal cancer: An independent prognostic factor
Authors
KeywordsHypopharyngeal cancer
Margin
Multivariate analysis
Prognostic factor
Radial clearance
Survival
Issue Date2002
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
Citation
Head And Neck, 2002, v. 24 n. 2, p. 181-190 How to Cite?
AbstractBackground. The depth of infiltration of tumor is of particular relevance in hypopharyngeal cancers, because most of them are seen late, and extensive infiltration into the muscle wall and the cartilage are not uncommon. Methods. The resected specimens of hypopharyngeal cancers were studied with whole-organ step-serial sectioning. The extent of infiltration into the thickness of the wall and the radial clearance were carefully documented. These parameters were correlated with the tumor recurrence and survival rates. Results. Most patients with hypopharyngeal cancer had a minimal radial margin; the radial clearance was <1 mm in 56% of the patients. Despite such a minimal margin, the local recurrence rate was only 19% and occurred mainly in the upper and lower resection margins. Radial clearance was an independent prognostic factor for overall survival, disease-free survival, and nodal recurrence-free survival on multivariate analysis. Conclusion. Radial clearance is an important independent prognostic factor, and it is recommended to be included in the routine pathologic reporting of the resected specimen in hypopharyngeal cancer. © 2002 John Wiley & Sons, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/84155
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, CMen_HK
dc.contributor.authorNg, WFen_HK
dc.contributor.authorLam, KHen_HK
dc.contributor.authorWei, WIen_HK
dc.contributor.authorYuen, APWen_HK
dc.date.accessioned2010-09-06T08:49:36Z-
dc.date.available2010-09-06T08:49:36Z-
dc.date.issued2002en_HK
dc.identifier.citationHead And Neck, 2002, v. 24 n. 2, p. 181-190en_HK
dc.identifier.issn1043-3074en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84155-
dc.description.abstractBackground. The depth of infiltration of tumor is of particular relevance in hypopharyngeal cancers, because most of them are seen late, and extensive infiltration into the muscle wall and the cartilage are not uncommon. Methods. The resected specimens of hypopharyngeal cancers were studied with whole-organ step-serial sectioning. The extent of infiltration into the thickness of the wall and the radial clearance were carefully documented. These parameters were correlated with the tumor recurrence and survival rates. Results. Most patients with hypopharyngeal cancer had a minimal radial margin; the radial clearance was <1 mm in 56% of the patients. Despite such a minimal margin, the local recurrence rate was only 19% and occurred mainly in the upper and lower resection margins. Radial clearance was an independent prognostic factor for overall survival, disease-free survival, and nodal recurrence-free survival on multivariate analysis. Conclusion. Radial clearance is an important independent prognostic factor, and it is recommended to be included in the routine pathologic reporting of the resected specimen in hypopharyngeal cancer. © 2002 John Wiley & Sons, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137en_HK
dc.relation.ispartofHead and Necken_HK
dc.subjectHypopharyngeal canceren_HK
dc.subjectMarginen_HK
dc.subjectMultivariate analysisen_HK
dc.subjectPrognostic factoren_HK
dc.subjectRadial clearanceen_HK
dc.subjectSurvivalen_HK
dc.titleRadial clearance in resection of hypopharyngeal cancer: An independent prognostic factoren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0017-8748&volume=24&issue=2&spage=181&epage=190&date=2002&atitle=Radial+clearance+in+resection+of+hypopharyngeal+cancer:+an+independent+prognostic+factoren_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hed.10002en_HK
dc.identifier.pmid11891948-
dc.identifier.scopuseid_2-s2.0-0036157446en_HK
dc.identifier.hkuros72148en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036157446&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue2en_HK
dc.identifier.spage181en_HK
dc.identifier.epage190en_HK
dc.identifier.isiWOS:000173623500009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, CM=7404652540en_HK
dc.identifier.scopusauthoridNg, WF=25940213100en_HK
dc.identifier.scopusauthoridLam, KH=7403657342en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.scopusauthoridYuen, APW=7006290111en_HK

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