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Article: Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach

TitleIdentification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach
Authors
Issue Date2006
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/cell
Citation
Cell, 2006, v. 125 n. 7, p. 1253-1267 How to Cite?
AbstractThe heterogeneity and instability of human tumors hamper straightforward identification of cancer-causing mutations through genomic approaches alone. Herein we describe a mouse model of liver cancer initiated from progenitor cells harboring defined cancer-predisposing lesions. Genome-wide analyses of tumors in this mouse model and in human hepatocellular carcinomas revealed a recurrent amplification at mouse chromosome 9qA1, the syntenic region of human chromosome 11q22. Gene-expression analyses delineated cIAP1, a known inhibitor of apoptosis, and Yap, a transcription factor, as candidate oncogenes in the amplicon. In the genetic context of their amplification, both cIAP1 and Yap accelerated tumorigenesis and were required to sustain rapid growth of amplicon-containing tumors. Furthermore, cIAP1 and Yap cooperated to promote tumorigenesis. Our results establish a tractable model of liver cancer, identify two oncogenes that cooperate by virtue of their coamplification in the same genomic locus, and suggest an efficient strategy for the annotation of human cancer genes. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84146
ISSN
2015 Impact Factor: 28.71
2015 SCImago Journal Rankings: 28.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZender, Len_HK
dc.contributor.authorSpector, MSen_HK
dc.contributor.authorXue, Wen_HK
dc.contributor.authorFlemming, Pen_HK
dc.contributor.authorCordonCardo, Cen_HK
dc.contributor.authorSilke, Jen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorLuk, JMen_HK
dc.contributor.authorWigler, Men_HK
dc.contributor.authorHannon, GJen_HK
dc.contributor.authorMu, Den_HK
dc.contributor.authorLucito, Ren_HK
dc.contributor.authorPowers, Sen_HK
dc.contributor.authorLowe, SWen_HK
dc.date.accessioned2010-09-06T08:49:30Z-
dc.date.available2010-09-06T08:49:30Z-
dc.date.issued2006en_HK
dc.identifier.citationCell, 2006, v. 125 n. 7, p. 1253-1267en_HK
dc.identifier.issn0092-8674en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84146-
dc.description.abstractThe heterogeneity and instability of human tumors hamper straightforward identification of cancer-causing mutations through genomic approaches alone. Herein we describe a mouse model of liver cancer initiated from progenitor cells harboring defined cancer-predisposing lesions. Genome-wide analyses of tumors in this mouse model and in human hepatocellular carcinomas revealed a recurrent amplification at mouse chromosome 9qA1, the syntenic region of human chromosome 11q22. Gene-expression analyses delineated cIAP1, a known inhibitor of apoptosis, and Yap, a transcription factor, as candidate oncogenes in the amplicon. In the genetic context of their amplification, both cIAP1 and Yap accelerated tumorigenesis and were required to sustain rapid growth of amplicon-containing tumors. Furthermore, cIAP1 and Yap cooperated to promote tumorigenesis. Our results establish a tractable model of liver cancer, identify two oncogenes that cooperate by virtue of their coamplification in the same genomic locus, and suggest an efficient strategy for the annotation of human cancer genes. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/cellen_HK
dc.relation.ispartofCellen_HK
dc.titleIdentification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approachen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0092-8674&volume=125&issue=7&spage=1253&epage=1267&date=2006&atitle=Identification+and+validation+of+oncogenes+in+liver+cancer+using+an+integrative+oncogenomic+approachen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cell.2006.05.030en_HK
dc.identifier.pmid16814713-
dc.identifier.scopuseid_2-s2.0-33745253109en_HK
dc.identifier.hkuros116844en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745253109&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume125en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1253en_HK
dc.identifier.epage1267en_HK
dc.identifier.isiWOS:000239104500010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZender, L=6603035987en_HK
dc.identifier.scopusauthoridSpector, MS=7101631010en_HK
dc.identifier.scopusauthoridXue, W=32267773000en_HK
dc.identifier.scopusauthoridFlemming, P=7005147650en_HK
dc.identifier.scopusauthoridCordonCardo, C=7103331026en_HK
dc.identifier.scopusauthoridSilke, J=6604029886en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.scopusauthoridWigler, M=7005241418en_HK
dc.identifier.scopusauthoridHannon, GJ=7006115520en_HK
dc.identifier.scopusauthoridMu, D=7005487573en_HK
dc.identifier.scopusauthoridLucito, R=6602333333en_HK
dc.identifier.scopusauthoridPowers, S=7203083045en_HK
dc.identifier.scopusauthoridLowe, SW=15064198100en_HK
dc.identifier.citeulike7299385-

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