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Article: Nonresectional therapies for hepatocellular carcinoma

TitleNonresectional therapies for hepatocellular carcinoma
Authors
Issue Date1997
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurg
Citation
American Journal Of Surgery, 1997, v. 173 n. 4, p. 358-365 How to Cite?
AbstractBACKGROUND: Surgical resection is generally accepted as the first choice of treatment for hepatocellular carcinoma (HCC). However, due to its multifocal nature, association with chronic liver disease, and frequent postresectional recurrence, nonresectional therapies are important in the management of a significant proportion of patients with HCC. DATA SOURCES: A literature review was performed on the current status of different nonresectional treatment modalities commonly employed for HCC. They include direct ablation methods, systemic chemotherapy, transcatheter arterial chemoembolization, external and targeting radiotherapy, hormonal therapy, and immunotherapy. Multidisciplinary therapy resulting in preoperative cytoreduction has also been reported with improvement of therapeutic results. CONCLUSION: Nonresectional therapies play an essential role in the treatment of inoperable HCC as they lead to satisfactory survival. Percutaneous ethanol injection and transcatheter arterial chemoembolization are the most frequently employed modalities, and they result in a 3-year survival rate of 55% to 70% and about 20%, respectively. Multidisciplinary therapy appears to be the current trend of management and improved survival is achieved especially when unresectable tumors are converted to resectable ones.
Persistent Identifierhttp://hdl.handle.net/10722/84143
ISSN
2015 Impact Factor: 2.403
2015 SCImago Journal Rankings: 1.286
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, CLen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:49:27Z-
dc.date.available2010-09-06T08:49:27Z-
dc.date.issued1997en_HK
dc.identifier.citationAmerican Journal Of Surgery, 1997, v. 173 n. 4, p. 358-365en_HK
dc.identifier.issn0002-9610en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84143-
dc.description.abstractBACKGROUND: Surgical resection is generally accepted as the first choice of treatment for hepatocellular carcinoma (HCC). However, due to its multifocal nature, association with chronic liver disease, and frequent postresectional recurrence, nonresectional therapies are important in the management of a significant proportion of patients with HCC. DATA SOURCES: A literature review was performed on the current status of different nonresectional treatment modalities commonly employed for HCC. They include direct ablation methods, systemic chemotherapy, transcatheter arterial chemoembolization, external and targeting radiotherapy, hormonal therapy, and immunotherapy. Multidisciplinary therapy resulting in preoperative cytoreduction has also been reported with improvement of therapeutic results. CONCLUSION: Nonresectional therapies play an essential role in the treatment of inoperable HCC as they lead to satisfactory survival. Percutaneous ethanol injection and transcatheter arterial chemoembolization are the most frequently employed modalities, and they result in a 3-year survival rate of 55% to 70% and about 20%, respectively. Multidisciplinary therapy appears to be the current trend of management and improved survival is achieved especially when unresectable tumors are converted to resectable ones.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurgen_HK
dc.relation.ispartofAmerican Journal of Surgeryen_HK
dc.rightsThe American Journal of Surgery. Copyright © Elsevier Inc.en_HK
dc.titleNonresectional therapies for hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9610&volume=173&spage=358&epage=365&date=1997&atitle=Nonresectional+therapies+for+hepatocellular+carcinomaen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0002-9610(96)00384-4en_HK
dc.identifier.pmid9136797en_HK
dc.identifier.scopuseid_2-s2.0-0030960950en_HK
dc.identifier.hkuros24780en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030960950&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume173en_HK
dc.identifier.issue4en_HK
dc.identifier.spage358en_HK
dc.identifier.epage365en_HK
dc.identifier.isiWOS:A1997WX19000023-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, CL=7409789712en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

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