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Article: Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma

TitleOverexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma
Authors
KeywordsHepatocellular carcinoma
NDRG1
Prognosis
Tumor differentiation
Vascular invasion
Issue Date2007
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/
Citation
Modern Pathology, 2007, v. 20 n. 1, p. 76-83 How to Cite?
AbstractHepatocellular carcinoma is a highly lethal cancer that typically has poor prognosis. Prognostic markers can help in its clinical management and in understanding the biology of poor prognosis. Through an earlier gene expression study, we identified N-Myc downregulated gene 1 (NDRG1) to be significantly highly expressed in hepatocellular carcinoma compared to nontumor liver. As NDRG1 is a differentiation-related gene with putative metastasis suppressor activity, we investigated the clinical significance of its overexpression. Quantitative real-time polymerase chain reaction using an independent set of patient samples confirmed the significant overexpression of NDRG1 in hepatocellular carcinoma compared to nontumor liver samples (P<0.001). Additionally, high levels of NDRG1 transcript correlated with shorter overall survival (P<0.001), late tumor stage (P=0.001), vascular invasion (P=0.003), large tumor size (P=0.011), and high Edmondson-Steiner histological grade (P=0.005). Using immunohistochemistry, NDRG1 protein was found to be significantly overexpressed in hepatocellular carcinoma samples compared to nontumor liver or cirrhotic and benign liver lesions (P<0.001). Among the hepatocellular carcinoma samples, those which are moderately and poorly differentiated express higher levels of NDRG1 protein than those which are well-differentiated (P<0.005). Additionally, hepatocellular carcinomas with vascular invasion also express elevated levels of NDRG1 protein compared to those without vascular invasion (significant at P<0.005). Our results suggest NDRG1 to be a likely tumor marker for hepatocellular carcinoma, the overexpression of which is correlated with tumor differentiation, vascular invasion, and overall survival. Its significantly elevated expression in hepatocellular carcinoma could be a useful indicator of tumor aggressiveness and therefore patient prognosis. © 2007 USCAP, Inc All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84142
ISSN
2015 Impact Factor: 5.485
2015 SCImago Journal Rankings: 2.803
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChua, MSen_HK
dc.contributor.authorSun, Hen_HK
dc.contributor.authorCheung, STen_HK
dc.contributor.authorMason, Ven_HK
dc.contributor.authorHiggins, Jen_HK
dc.contributor.authorRoss, DTen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorSo, Sen_HK
dc.date.accessioned2010-09-06T08:49:27Z-
dc.date.available2010-09-06T08:49:27Z-
dc.date.issued2007en_HK
dc.identifier.citationModern Pathology, 2007, v. 20 n. 1, p. 76-83en_HK
dc.identifier.issn0893-3952en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84142-
dc.description.abstractHepatocellular carcinoma is a highly lethal cancer that typically has poor prognosis. Prognostic markers can help in its clinical management and in understanding the biology of poor prognosis. Through an earlier gene expression study, we identified N-Myc downregulated gene 1 (NDRG1) to be significantly highly expressed in hepatocellular carcinoma compared to nontumor liver. As NDRG1 is a differentiation-related gene with putative metastasis suppressor activity, we investigated the clinical significance of its overexpression. Quantitative real-time polymerase chain reaction using an independent set of patient samples confirmed the significant overexpression of NDRG1 in hepatocellular carcinoma compared to nontumor liver samples (P<0.001). Additionally, high levels of NDRG1 transcript correlated with shorter overall survival (P<0.001), late tumor stage (P=0.001), vascular invasion (P=0.003), large tumor size (P=0.011), and high Edmondson-Steiner histological grade (P=0.005). Using immunohistochemistry, NDRG1 protein was found to be significantly overexpressed in hepatocellular carcinoma samples compared to nontumor liver or cirrhotic and benign liver lesions (P<0.001). Among the hepatocellular carcinoma samples, those which are moderately and poorly differentiated express higher levels of NDRG1 protein than those which are well-differentiated (P<0.005). Additionally, hepatocellular carcinomas with vascular invasion also express elevated levels of NDRG1 protein compared to those without vascular invasion (significant at P<0.005). Our results suggest NDRG1 to be a likely tumor marker for hepatocellular carcinoma, the overexpression of which is correlated with tumor differentiation, vascular invasion, and overall survival. Its significantly elevated expression in hepatocellular carcinoma could be a useful indicator of tumor aggressiveness and therefore patient prognosis. © 2007 USCAP, Inc All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/en_HK
dc.relation.ispartofModern Pathologyen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectNDRG1en_HK
dc.subjectPrognosisen_HK
dc.subjectTumor differentiationen_HK
dc.subjectVascular invasionen_HK
dc.titleOverexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0893-3952&volume=20&issue=1&spage=76&epage=83&date=2007&atitle=Overexpression+of+NDRG1+is+an+indicator+of+poor+prognosis+in+hepatocellular+carcinomaen_HK
dc.identifier.emailCheung, ST: stcheung@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityCheung, ST=rp00457en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/modpathol.3800711en_HK
dc.identifier.pmid17170744-
dc.identifier.scopuseid_2-s2.0-33845705732en_HK
dc.identifier.hkuros125532en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845705732&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue1en_HK
dc.identifier.spage76en_HK
dc.identifier.epage83en_HK
dc.identifier.isiWOS:000243005000010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChua, MS=7006092807en_HK
dc.identifier.scopusauthoridSun, H=49762306000en_HK
dc.identifier.scopusauthoridCheung, ST=7202473497en_HK
dc.identifier.scopusauthoridMason, V=7004690511en_HK
dc.identifier.scopusauthoridHiggins, J=25642411200en_HK
dc.identifier.scopusauthoridRoss, DT=7404449443en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridSo, S=7102397384en_HK

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