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Article: Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma

TitleLiver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma
Authors
Issue Date2006
PublisherAmerican Association for Cancer Research.
Citation
Clinical Cancer Research, 2006, v. 12 n. 17, p. 5248-5252 How to Cite?
AbstractPurpose: Hepatocellular carcinoma (HCC), the most common form of liver cancer, is a leading cause of cancer death worldwide. We previously showed that aberrant mRNA splicing of the liver intestine-cadherin gene CDH17 in liver tissues was triggered by the specific constellation of two CDH17 single nucleotide polymorphisms (651T and IVS6+35G). CDH17 aberrant splicing was highly associated with tumor dissemination and shorter survival of HCC patients. Consequently, it is highly relevant to assess whether the presence of these single nucleotide polymorphisms in the general population represents a risk to the development of HCC. Experimental Design: We conducted a case-control study including 164 HCC and 99 cirrhosis patients and 293 healthy controls. Genotyping was done by PCR and direct sequencing. Odds ratio (OR) and χ 2 analysis were used to analyze genotypes and haplotypes. Results: Genotypes 651TT [OR, 2.62; 95% confidence interval (95% CI), 1.34-5.03] and IVS6+35 GG (OR, 1.95; 95% CI, 1.04-3.62) were highly associated with HCC disease. The 651T (C>T) and IVS6+35G (A>G) alleles were also overrepresented in HCC patients and, in particular, the T-G haplotype was the most prevalent in HCC patients when compared with healthy controls (OR, 1.57; 95% CI, 1.167-2.109; P = 0.004), which was in agreement with the aberrant splicing observed in tumor tissues. There was no significant difference in genotype and allele frequencies between cirrhosis patients and controls. Conclusion: The functional T-G haplotype of CDH17 (651 C>T and IVS6+35A>G) is a genetic susceptibility factor for the development of HCC in a Chinese population. © 2006 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/84131
ISSN
2015 Impact Factor: 8.738
2015 SCImago Journal Rankings: 5.314
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXiao, QWen_HK
dc.contributor.authorLuk, JMen_HK
dc.contributor.authorGarciaBarcelo, Men_HK
dc.contributor.authorMiao, Xen_HK
dc.contributor.authorLeung, PPen_HK
dc.contributor.authorHo, DWen_HK
dc.contributor.authorCheung, STen_HK
dc.contributor.authorLam, BYen_HK
dc.contributor.authorCheung, CKen_HK
dc.contributor.authorWong, ASen_HK
dc.contributor.authorLau, SSen_HK
dc.contributor.authorMan, TSen_HK
dc.contributor.authorWan, CYen_HK
dc.contributor.authorCai, Qen_HK
dc.contributor.authorLiu, KSen_HK
dc.contributor.authorChee, KHen_HK
dc.contributor.authorLau, GKen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorWong, Jen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:49:19Z-
dc.date.available2010-09-06T08:49:19Z-
dc.date.issued2006en_HK
dc.identifier.citationClinical Cancer Research, 2006, v. 12 n. 17, p. 5248-5252en_HK
dc.identifier.issn1078-0432en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84131-
dc.description.abstractPurpose: Hepatocellular carcinoma (HCC), the most common form of liver cancer, is a leading cause of cancer death worldwide. We previously showed that aberrant mRNA splicing of the liver intestine-cadherin gene CDH17 in liver tissues was triggered by the specific constellation of two CDH17 single nucleotide polymorphisms (651T and IVS6+35G). CDH17 aberrant splicing was highly associated with tumor dissemination and shorter survival of HCC patients. Consequently, it is highly relevant to assess whether the presence of these single nucleotide polymorphisms in the general population represents a risk to the development of HCC. Experimental Design: We conducted a case-control study including 164 HCC and 99 cirrhosis patients and 293 healthy controls. Genotyping was done by PCR and direct sequencing. Odds ratio (OR) and χ 2 analysis were used to analyze genotypes and haplotypes. Results: Genotypes 651TT [OR, 2.62; 95% confidence interval (95% CI), 1.34-5.03] and IVS6+35 GG (OR, 1.95; 95% CI, 1.04-3.62) were highly associated with HCC disease. The 651T (C>T) and IVS6+35G (A>G) alleles were also overrepresented in HCC patients and, in particular, the T-G haplotype was the most prevalent in HCC patients when compared with healthy controls (OR, 1.57; 95% CI, 1.167-2.109; P = 0.004), which was in agreement with the aberrant splicing observed in tumor tissues. There was no significant difference in genotype and allele frequencies between cirrhosis patients and controls. Conclusion: The functional T-G haplotype of CDH17 (651 C>T and IVS6+35A>G) is a genetic susceptibility factor for the development of HCC in a Chinese population. © 2006 American Association for Cancer Research.en_HK
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research.en_HK
dc.relation.ispartofClinical Cancer Researchen_HK
dc.titleLiver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1078-0432&volume=12&issue=17&spage=5248&epage=5252 (corresponding author)&date=2006&atitle=Liver+intestine-cadherin+(CDH17)+haplotype+is+associated+with+increased+risk+of+hepatocellular+carcinomaen_HK
dc.identifier.emailXiao, QW: xqwang@hku.hken_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.emailGarciaBarcelo, M: mmgarcia@hku.hken_HK
dc.identifier.emailSiu, TC: stcheung@hkucc.hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityXiao, QW=rp00507en_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.identifier.authorityGarciaBarcelo, M=rp00445en_HK
dc.identifier.authoritySiu, TC=rp00457en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1158/1078-0432.CCR-06-0558en_HK
dc.identifier.pmid16951245-
dc.identifier.scopuseid_2-s2.0-33749040274en_HK
dc.identifier.hkuros125159en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33749040274&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue17en_HK
dc.identifier.spage5248en_HK
dc.identifier.epage5252en_HK
dc.identifier.isiWOS:000240392000035-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXiao, QW=17343159900en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.scopusauthoridGarciaBarcelo, M=6701767303en_HK
dc.identifier.scopusauthoridMiao, X=7102585391en_HK
dc.identifier.scopusauthoridLeung, PP=7401749062en_HK
dc.identifier.scopusauthoridHo, DW=7402971906en_HK
dc.identifier.scopusauthoridSiu, TC=7202473497en_HK
dc.identifier.scopusauthoridLam, BY=7102023588en_HK
dc.identifier.scopusauthoridCheung, CK=8714367400en_HK
dc.identifier.scopusauthoridWong, AS=8441341200en_HK
dc.identifier.scopusauthoridLau, SS=9234106700en_HK
dc.identifier.scopusauthoridMan, TS=14630657600en_HK
dc.identifier.scopusauthoridWan, CY=8343494200en_HK
dc.identifier.scopusauthoridCai, Q=25935876300en_HK
dc.identifier.scopusauthoridLiu, KS=25031724200en_HK
dc.identifier.scopusauthoridChee, KH=14629958000en_HK
dc.identifier.scopusauthoridLau, GK=7102301257en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK
dc.identifier.scopusauthoridSheung, TF=6506234707en_HK

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