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Article: Incomplete ablation after radiofrequency ablation of hepatocellular carcinoma: Analysis of risk factors and prognostic factors

TitleIncomplete ablation after radiofrequency ablation of hepatocellular carcinoma: Analysis of risk factors and prognostic factors
Authors
KeywordsHepatocellular carcinoma
Prognosis
Radiofrequency ablation
Residual
Risk factors
Issue Date2008
PublisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org
Citation
Annals Of Surgical Oncology, 2008, v. 15 n. 3, p. 782-790 How to Cite?
AbstractBackground: Complete ablation rates after a single session of radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) vary from 48% to 97%. Limited data are available regarding risk factors and prognostic significance of incomplete ablation. Methods: Between April 2001 and March 2006, 298 patients underwent RFA of 393 HCC nodules with an intent of complete ablation after a single session. Risk factors for incomplete ablation and its effect on overall survival were analyzed. Results: Two hundred seventy-three (91.6%) underwent complete tumor ablation, whereas the other 25 (8.4%) underwent incomplete tumor ablation after a single session of RFA. By multivariate analysis, tumor size >3 cm (P = .049) was found to be the only independent risk factor for incomplete ablation. There was no statistically significant difference in overall survival between patients with complete and incomplete ablation. By univariate analysis, no previous transarterial chemoembolization (TACE), preoperative serum alfa-fetoprotein ≤100 μg/mL, and complete response after further treatment of incomplete ablation were associated with better overall survival in patients with incomplete ablation. Conclusions: This study demonstrated that incomplete ablation after RFA of HCC was associated with tumor size >3 cm. Our data also suggest that aggressive further treatment of tumors with incomplete ablation aiming at complete tumor response improves overall survival. © 2007 Society of Surgical Oncology.
Persistent Identifierhttp://hdl.handle.net/10722/84078
ISSN
2015 Impact Factor: 3.655
2015 SCImago Journal Rankings: 1.902
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, VWTen_HK
dc.contributor.authorNg, KKen_HK
dc.contributor.authorChok, KSHen_HK
dc.contributor.authorCheung, TTen_HK
dc.contributor.authorYuen, Jen_HK
dc.contributor.authorTung, Hen_HK
dc.contributor.authorTso, WKen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorPoon, RTPen_HK
dc.date.accessioned2010-09-06T08:48:40Z-
dc.date.available2010-09-06T08:48:40Z-
dc.date.issued2008en_HK
dc.identifier.citationAnnals Of Surgical Oncology, 2008, v. 15 n. 3, p. 782-790en_HK
dc.identifier.issn1068-9265en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84078-
dc.description.abstractBackground: Complete ablation rates after a single session of radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) vary from 48% to 97%. Limited data are available regarding risk factors and prognostic significance of incomplete ablation. Methods: Between April 2001 and March 2006, 298 patients underwent RFA of 393 HCC nodules with an intent of complete ablation after a single session. Risk factors for incomplete ablation and its effect on overall survival were analyzed. Results: Two hundred seventy-three (91.6%) underwent complete tumor ablation, whereas the other 25 (8.4%) underwent incomplete tumor ablation after a single session of RFA. By multivariate analysis, tumor size >3 cm (P = .049) was found to be the only independent risk factor for incomplete ablation. There was no statistically significant difference in overall survival between patients with complete and incomplete ablation. By univariate analysis, no previous transarterial chemoembolization (TACE), preoperative serum alfa-fetoprotein ≤100 μg/mL, and complete response after further treatment of incomplete ablation were associated with better overall survival in patients with incomplete ablation. Conclusions: This study demonstrated that incomplete ablation after RFA of HCC was associated with tumor size >3 cm. Our data also suggest that aggressive further treatment of tumors with incomplete ablation aiming at complete tumor response improves overall survival. © 2007 Society of Surgical Oncology.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.orgen_HK
dc.relation.ispartofAnnals of Surgical Oncologyen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectPrognosisen_HK
dc.subjectRadiofrequency ablationen_HK
dc.subjectResidualen_HK
dc.subjectRisk factorsen_HK
dc.titleIncomplete ablation after radiofrequency ablation of hepatocellular carcinoma: Analysis of risk factors and prognostic factorsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1068-9265&volume=15&issue=3&spage=782&epage=790&date=2008&atitle=Incomplete+ablation+after+radiofrequency+ablation+of+hepatocellular+carcinoma:+analysis+of+risk+factors+and+prognostic+factorsen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1245/s10434-007-9733-9en_HK
dc.identifier.pmid18095030-
dc.identifier.scopuseid_2-s2.0-39149139961en_HK
dc.identifier.hkuros140975en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39149139961&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue3en_HK
dc.identifier.spage782en_HK
dc.identifier.epage790en_HK
dc.identifier.isiWOS:000252990700018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLam, VWT=14828037100en_HK
dc.identifier.scopusauthoridNg, KK=7403179075en_HK
dc.identifier.scopusauthoridChok, KSH=6508229426en_HK
dc.identifier.scopusauthoridCheung, TT=7103334165en_HK
dc.identifier.scopusauthoridYuen, J=7102620431en_HK
dc.identifier.scopusauthoridTung, H=23089742300en_HK
dc.identifier.scopusauthoridTso, WK=7006905486en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK

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