File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Decreased tyrosine kinase C expression may reflect developmental abnormalities in Hirschsprung's disease and idiopathic slow-transit constipation

TitleDecreased tyrosine kinase C expression may reflect developmental abnormalities in Hirschsprung's disease and idiopathic slow-transit constipation
Authors
Issue Date2001
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uk
Citation
British Journal Of Surgery, 2001, v. 88 n. 4, p. 545-552 How to Cite?
AbstractBackground: Some Patients With Hirschsprung's Disease Have Refractory Constipation Following Excision Of Aganglionic Bowel, As Do Patients With Idiopathic Slow-Transit Constipation (Stc). Gut Motility Depends On Enteric Neuronal Development In Response To Expression Of Trophic Factors And Their Receptors. Recent Studies Indicate The Importance Of Neurotrophin 3 (Nt-3) And Its High-Affinity Receptor Tyrosine Kinase C (Trk C) In Enteric Neuronal Development. Methods: Blinded Quantitative Immunohistochemical Analysis Of Colon From Patients With Hirschsprung's Disease (Aganglionic, Hypoganglionic And Normoganglionic) (N = 5), Stc (N = 6) And Appropriate Age-Matched Control Tissues (N = 5) Was Performed For Nt-3 And Trk C. Sural Nerve Morphometry And Immunostaining Were Undertaken In Three Patients With Stc Who Had Abnormalities On Limb Autonomic And Sensory Testing. Results: A Significantly Higher Proportion Of Submucous Plexus Neurones Was Trk C Immunoreactive In Control Infant Than Adult Colon (Mean(S.E.M.) 73(9) Versus 16(3) Per Cent Of The Total; P < 0.001), In Accord With A Role In Development. The Proportion Of Submucous Plexus Trk C-Immunoreactive Neurones Was Reduced In Colon From Patients With Hirschsprung's Disease (28(7) Per Cent Of Total In Normoganglionic Hirschsprung's Disease; P < 0.007 Versus Infant Controls) And Stc (10(1) Per Cent Of Total; P = 0.053 Versus Adult Controls). No Abnormalities Of Stc Sural Nerves Were Detected By Morphometry Or Immunostaining. Conclusion: Decreased Trk C Expression May Reflect Developmental Abnormalities In Hirschsprung's Disease And Idiopathic Stc. Trk C Activation By Nt-3 Or Drugs May Provide Novel Treatments.
Persistent Identifierhttp://hdl.handle.net/10722/84070
ISSN
2015 Impact Factor: 5.596
2015 SCImago Journal Rankings: 2.966
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFacer, Pen_HK
dc.contributor.authorKnowles, CHen_HK
dc.contributor.authorThomas, PKen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorWilliams, NSen_HK
dc.contributor.authorAnand, Pen_HK
dc.date.accessioned2010-09-06T08:48:34Z-
dc.date.available2010-09-06T08:48:34Z-
dc.date.issued2001en_HK
dc.identifier.citationBritish Journal Of Surgery, 2001, v. 88 n. 4, p. 545-552en_US
dc.identifier.issn0007-1323en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84070-
dc.description.abstractBackground: Some Patients With Hirschsprung's Disease Have Refractory Constipation Following Excision Of Aganglionic Bowel, As Do Patients With Idiopathic Slow-Transit Constipation (Stc). Gut Motility Depends On Enteric Neuronal Development In Response To Expression Of Trophic Factors And Their Receptors. Recent Studies Indicate The Importance Of Neurotrophin 3 (Nt-3) And Its High-Affinity Receptor Tyrosine Kinase C (Trk C) In Enteric Neuronal Development. Methods: Blinded Quantitative Immunohistochemical Analysis Of Colon From Patients With Hirschsprung's Disease (Aganglionic, Hypoganglionic And Normoganglionic) (N = 5), Stc (N = 6) And Appropriate Age-Matched Control Tissues (N = 5) Was Performed For Nt-3 And Trk C. Sural Nerve Morphometry And Immunostaining Were Undertaken In Three Patients With Stc Who Had Abnormalities On Limb Autonomic And Sensory Testing. Results: A Significantly Higher Proportion Of Submucous Plexus Neurones Was Trk C Immunoreactive In Control Infant Than Adult Colon (Mean(S.E.M.) 73(9) Versus 16(3) Per Cent Of The Total; P < 0.001), In Accord With A Role In Development. The Proportion Of Submucous Plexus Trk C-Immunoreactive Neurones Was Reduced In Colon From Patients With Hirschsprung's Disease (28(7) Per Cent Of Total In Normoganglionic Hirschsprung's Disease; P < 0.007 Versus Infant Controls) And Stc (10(1) Per Cent Of Total; P = 0.053 Versus Adult Controls). No Abnormalities Of Stc Sural Nerves Were Detected By Morphometry Or Immunostaining. Conclusion: Decreased Trk C Expression May Reflect Developmental Abnormalities In Hirschsprung's Disease And Idiopathic Stc. Trk C Activation By Nt-3 Or Drugs May Provide Novel Treatments.en_US
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uken_HK
dc.relation.ispartofBritish Journal of Surgeryen_HK
dc.rightsBritish Journal of Surgery. Copyright © John Wiley & Sons Ltd.en_HK
dc.titleDecreased tyrosine kinase C expression may reflect developmental abnormalities in Hirschsprung's disease and idiopathic slow-transit constipationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1323&volume=88&spage=545&epage=552&date=2001&atitle=Decreased+tyrosine+kinase+C+expression+may+reflect+developmental+abnormalities+in+Hirschsprung%27s+disease+and+idiopathic+slow-transit+constipationen_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2168.2001.01731.xen_US
dc.identifier.pmid11298623-
dc.identifier.scopuseid_2-s2.0-0035067359en_US
dc.identifier.hkuros61217en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035067359&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume88en_US
dc.identifier.issue4en_US
dc.identifier.spage545en_US
dc.identifier.epage552en_US
dc.identifier.isiWOS:000168126000011-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats