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Article: Survival in patients with chronic lower extremity ischemia: A risk factor analysis

TitleSurvival in patients with chronic lower extremity ischemia: A risk factor analysis
Authors
Issue Date2000
PublisherElsevier Inc.
Citation
Annals Of Vascular Surgery, 2000, v. 14 n. 2, p. 158-165 How to Cite?
AbstractThis is a prospective cohort comparison study aiming to determine the mortality of patients with peripheral arterial occlusive disease (PAOD) and identify the risk factors affecting their survival. Data regarding demographic and biochemical risk factors, and lower limb disease severity classified by vascular laboratory criteria were collected prospectively from 665 consecutive patients presenting with symptoms of peripheral arterial occlusive disease. The effect of patient and disease risk factors on survival was analyzed by the life-table method and independent significant variables examined by a multivariate Cox regression model. The cumulative survival for all patients at 1, 3, and 5 years were 86.1, 71.2, and 55.8%, respectively, with a median survival of 72.2 months. Female sex, age, smoking, heart disease, renal disease, respiratory disease, stroke, critical ischemia, lowest anklebrachial index, no vascular reconstruction, and major amputation were associated with higher mortality. Lipid and biochemical variables were not significant determinants. Using multivariate Cox regression, age (>70), disease severity, anklebrachial index (<0.5), no vascular reconstruction, diabetes mellitus, and renal and cardiorespiratory diseases were identified as independent risk factors affecting patient survival. The survival of patients with PAOD is poor compared with the general population. Significant patient-related variables were largely coexisting diseases and advanced age, whereas the other risk factors for atherosclerosis are less influential. Disease severity may bear a direct relationship to mortality, and patients with critical ischemia have the worst prognosis. Early disease detection and timely vascular reconstruction may lead to an improvement in overall survival.
Persistent Identifierhttp://hdl.handle.net/10722/84066
ISSN
2015 Impact Factor: 1.045
2015 SCImago Journal Rankings: 0.586
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, SWKen_HK
dc.contributor.authorTing, ACWen_HK
dc.contributor.authorLau, Hen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:48:31Z-
dc.date.available2010-09-06T08:48:31Z-
dc.date.issued2000en_HK
dc.identifier.citationAnnals Of Vascular Surgery, 2000, v. 14 n. 2, p. 158-165en_HK
dc.identifier.issn0890-5096en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84066-
dc.description.abstractThis is a prospective cohort comparison study aiming to determine the mortality of patients with peripheral arterial occlusive disease (PAOD) and identify the risk factors affecting their survival. Data regarding demographic and biochemical risk factors, and lower limb disease severity classified by vascular laboratory criteria were collected prospectively from 665 consecutive patients presenting with symptoms of peripheral arterial occlusive disease. The effect of patient and disease risk factors on survival was analyzed by the life-table method and independent significant variables examined by a multivariate Cox regression model. The cumulative survival for all patients at 1, 3, and 5 years were 86.1, 71.2, and 55.8%, respectively, with a median survival of 72.2 months. Female sex, age, smoking, heart disease, renal disease, respiratory disease, stroke, critical ischemia, lowest anklebrachial index, no vascular reconstruction, and major amputation were associated with higher mortality. Lipid and biochemical variables were not significant determinants. Using multivariate Cox regression, age (>70), disease severity, anklebrachial index (<0.5), no vascular reconstruction, diabetes mellitus, and renal and cardiorespiratory diseases were identified as independent risk factors affecting patient survival. The survival of patients with PAOD is poor compared with the general population. Significant patient-related variables were largely coexisting diseases and advanced age, whereas the other risk factors for atherosclerosis are less influential. Disease severity may bear a direct relationship to mortality, and patients with critical ischemia have the worst prognosis. Early disease detection and timely vascular reconstruction may lead to an improvement in overall survival.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc.en_HK
dc.relation.ispartofAnnals of Vascular Surgeryen_HK
dc.rightsAnnals of Vascular Surgery. Copyright © Elsevier Inc.en_HK
dc.titleSurvival in patients with chronic lower extremity ischemia: A risk factor analysisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0890-5096&volume=14&spage=158&epage=165&date=2000&atitle=Survival+in+patients+with+chronic+lower+extremity+ischemia:+a+risk+factor+analysisen_HK
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityCheng, SWK=rp00374en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s100169910028en_HK
dc.identifier.pmid10742431-
dc.identifier.scopuseid_2-s2.0-0034018735en_HK
dc.identifier.hkuros48702en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034018735&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue2en_HK
dc.identifier.spage158en_HK
dc.identifier.epage165en_HK
dc.identifier.isiWOS:000085806900011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, SWK=7404684779en_HK
dc.identifier.scopusauthoridTing, ACW=7102858552en_HK
dc.identifier.scopusauthoridLau, H=7201497812en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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