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Article: Irradiation-induced extracranial carotid stenosis in patients with head and neck malignancies

TitleIrradiation-induced extracranial carotid stenosis in patients with head and neck malignancies
Authors
Issue Date1999
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurg
Citation
American Journal Of Surgery, 1999, v. 178 n. 4, p. 323-328 How to Cite?
AbstractBackground: Carotid stenosis is a recognized complication of external irradiation to the head and neck for malignancy. This study aim to investigate the pattern and prevalence of radiation induced carotid disease, and to identify risk factors associated with significant stenosis. Methods: In a comparative cross-sectional study, carotid arteries color flow duplex scan was performed on 240 patients who had received external irradiation to the head and neck area, with a mean interval of 72 months from radiotherapy. They consisted of 181 men and 59 women, with a mean age of 59 years. Fifteen patients had a history of cerebrovascular symptoms. Results: Internal carotid artery (ICA) stenosis of 70% or greater was detected in 29 arteries in 24 patients. Common carotid artery (CCA) disease of ≥70% was present in 13 arteries in 12 patients. Overall 28 patients had significant ICA/CCA disease (11.7%). Patients with nasopharyngeal and laryngeal carcinoma had more cerebrovascular symptoms, and more frequent CCA stenosis. Significant ICA/CCA stenosis was associated with age, smoking, coronary heart disease, stroke, no head and neck surgery, time interval from radiotherapy, and the site of primary tumor. On logistic regression analysis age (>60 years), cerebrovascular symptoms, interval from irradiation (>5 years), and nasopharynx and larynx cancer were found to be independent significant (P <0.05) predictors of 70% or greater ICA/CCA stenosis. Conclusions: Patients who had received radiotherapy to the head and neck have a high risk of developing significant carotid stenosis. Routine duplex ultrasound screening in these patients is indicated.
Persistent Identifierhttp://hdl.handle.net/10722/84062
ISSN
2015 Impact Factor: 2.403
2015 SCImago Journal Rankings: 1.286
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, SWKen_HK
dc.contributor.authorWu, LLHen_HK
dc.contributor.authorTing, ACWen_HK
dc.contributor.authorLau, Hen_HK
dc.contributor.authorLam, LKen_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2010-09-06T08:48:29Z-
dc.date.available2010-09-06T08:48:29Z-
dc.date.issued1999en_HK
dc.identifier.citationAmerican Journal Of Surgery, 1999, v. 178 n. 4, p. 323-328en_HK
dc.identifier.issn0002-9610en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84062-
dc.description.abstractBackground: Carotid stenosis is a recognized complication of external irradiation to the head and neck for malignancy. This study aim to investigate the pattern and prevalence of radiation induced carotid disease, and to identify risk factors associated with significant stenosis. Methods: In a comparative cross-sectional study, carotid arteries color flow duplex scan was performed on 240 patients who had received external irradiation to the head and neck area, with a mean interval of 72 months from radiotherapy. They consisted of 181 men and 59 women, with a mean age of 59 years. Fifteen patients had a history of cerebrovascular symptoms. Results: Internal carotid artery (ICA) stenosis of 70% or greater was detected in 29 arteries in 24 patients. Common carotid artery (CCA) disease of ≥70% was present in 13 arteries in 12 patients. Overall 28 patients had significant ICA/CCA disease (11.7%). Patients with nasopharyngeal and laryngeal carcinoma had more cerebrovascular symptoms, and more frequent CCA stenosis. Significant ICA/CCA stenosis was associated with age, smoking, coronary heart disease, stroke, no head and neck surgery, time interval from radiotherapy, and the site of primary tumor. On logistic regression analysis age (>60 years), cerebrovascular symptoms, interval from irradiation (>5 years), and nasopharynx and larynx cancer were found to be independent significant (P <0.05) predictors of 70% or greater ICA/CCA stenosis. Conclusions: Patients who had received radiotherapy to the head and neck have a high risk of developing significant carotid stenosis. Routine duplex ultrasound screening in these patients is indicated.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurgen_HK
dc.relation.ispartofAmerican Journal of Surgeryen_HK
dc.rightsThe American Journal of Surgery. Copyright © Elsevier Inc.en_HK
dc.titleIrradiation-induced extracranial carotid stenosis in patients with head and neck malignanciesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9610&volume=178&spage=323&epage=328&date=1999&atitle=Irradiation-induced+extracranial+carotid+stenosis+in+patients+with+head+and+neck+malignanciesen_HK
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityCheng, SWK=rp00374en_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0002-9610(99)00184-1en_HK
dc.identifier.pmid10587192-
dc.identifier.scopuseid_2-s2.0-0032701840en_HK
dc.identifier.hkuros47716en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032701840&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume178en_HK
dc.identifier.issue4en_HK
dc.identifier.spage323en_HK
dc.identifier.epage328en_HK
dc.identifier.isiWOS:000083700400013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, SWK=7404684779en_HK
dc.identifier.scopusauthoridWu, LLH=7404903103en_HK
dc.identifier.scopusauthoridTing, ACW=7102858552en_HK
dc.identifier.scopusauthoridLau, H=7201497812en_HK
dc.identifier.scopusauthoridLam, LK=7201984637en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK

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