File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Stereotactic Radiosurgery Versus Gold Grain Implantation in Salvaging Local Failures of Nasopharyngeal Carcinoma
  • Basic View
  • Metadata View
  • XML View
TitleStereotactic Radiosurgery Versus Gold Grain Implantation in Salvaging Local Failures of Nasopharyngeal Carcinoma
 
AuthorsChua, DTT1
Wei, WI1
Sham, JST1
Hung, KN1
Au, GKH1
 
KeywordsGold grain implantation
Local failure
Nasopharyngeal carcinoma
Stereotactic radiosurgery
 
Issue Date2007
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
 
CitationInternational Journal Of Radiation Oncology Biology Physics, 2007, v. 69 n. 2, p. 469-474 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijrobp.2007.03.012
 
AbstractBackground: Limited local failure of nasopharyngeal carcinoma (NPC) can often be salvaged by reirradiation using different techniques. Both gold grain implantation (GGI) and stereotactic radiosurgery (SRS) have been used as salvage treatment of NPC but the relative efficacy of these two treatments is not known. Methods and Materials: A total of 74 patients with local NPC failure were included in this retrospective analysis. Of these patients, 37 underwent SRS (median dose, 12.5 Gy) and 37 split-palatal GGI at a dose of 60 Gy. The two groups were individually matched for prognostic factors, except for tumor volume. The median follow-up was 42 months. Results: Local control was better in the GGI group. The 3-year local failure-free rate was 77.9% for the GGI group compared with 68.3% for the SRS group. However, the difference was not statistically significant (p = 0.098). In the subgroup with a tumor volume of ≤5 cm 3, the 3-year local failure-free rates were similar, with 79.3% in the GGI group and 72.4% in the SRS group. Neuroendocrine complications were more common in the SRS group, and headache and fistula were more common in the GGI group. Conclusion: Stereotactic radiosurgery and GGI are both effective salvage treatment for NPC. In patients with limited local failure, both yielded comparable high tumor control rates. © 2007 Elsevier Inc. All rights reserved.
 
ISSN0360-3016
2013 Impact Factor: 4.176
 
DOIhttp://dx.doi.org/10.1016/j.ijrobp.2007.03.012
 
ISI Accession Number IDWOS:000249796100021
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChua, DTT
 
dc.contributor.authorWei, WI
 
dc.contributor.authorSham, JST
 
dc.contributor.authorHung, KN
 
dc.contributor.authorAu, GKH
 
dc.date.accessioned2010-09-06T08:48:23Z
 
dc.date.available2010-09-06T08:48:23Z
 
dc.date.issued2007
 
dc.description.abstractBackground: Limited local failure of nasopharyngeal carcinoma (NPC) can often be salvaged by reirradiation using different techniques. Both gold grain implantation (GGI) and stereotactic radiosurgery (SRS) have been used as salvage treatment of NPC but the relative efficacy of these two treatments is not known. Methods and Materials: A total of 74 patients with local NPC failure were included in this retrospective analysis. Of these patients, 37 underwent SRS (median dose, 12.5 Gy) and 37 split-palatal GGI at a dose of 60 Gy. The two groups were individually matched for prognostic factors, except for tumor volume. The median follow-up was 42 months. Results: Local control was better in the GGI group. The 3-year local failure-free rate was 77.9% for the GGI group compared with 68.3% for the SRS group. However, the difference was not statistically significant (p = 0.098). In the subgroup with a tumor volume of ≤5 cm 3, the 3-year local failure-free rates were similar, with 79.3% in the GGI group and 72.4% in the SRS group. Neuroendocrine complications were more common in the SRS group, and headache and fistula were more common in the GGI group. Conclusion: Stereotactic radiosurgery and GGI are both effective salvage treatment for NPC. In patients with limited local failure, both yielded comparable high tumor control rates. © 2007 Elsevier Inc. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationInternational Journal Of Radiation Oncology Biology Physics, 2007, v. 69 n. 2, p. 469-474 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijrobp.2007.03.012
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijrobp.2007.03.012
 
dc.identifier.epage474
 
dc.identifier.hkuros139674
 
dc.identifier.isiWOS:000249796100021
 
dc.identifier.issn0360-3016
2013 Impact Factor: 4.176
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid17869663
 
dc.identifier.scopuseid_2-s2.0-34548522202
 
dc.identifier.spage469
 
dc.identifier.urihttp://hdl.handle.net/10722/84054
 
dc.identifier.volume69
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
 
dc.publisher.placeUnited States
 
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsInternational Journal of Radiation: Oncology - Biology - Physics. Copyright © Elsevier Inc.
 
dc.subjectGold grain implantation
 
dc.subjectLocal failure
 
dc.subjectNasopharyngeal carcinoma
 
dc.subjectStereotactic radiosurgery
 
dc.titleStereotactic Radiosurgery Versus Gold Grain Implantation in Salvaging Local Failures of Nasopharyngeal Carcinoma
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Chua, DTT</contributor.author>
<contributor.author>Wei, WI</contributor.author>
<contributor.author>Sham, JST</contributor.author>
<contributor.author>Hung, KN</contributor.author>
<contributor.author>Au, GKH</contributor.author>
<date.accessioned>2010-09-06T08:48:23Z</date.accessioned>
<date.available>2010-09-06T08:48:23Z</date.available>
<date.issued>2007</date.issued>
<identifier.citation>International Journal Of Radiation Oncology Biology Physics, 2007, v. 69 n. 2, p. 469-474</identifier.citation>
<identifier.issn>0360-3016</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/84054</identifier.uri>
<description.abstract>Background: Limited local failure of nasopharyngeal carcinoma (NPC) can often be salvaged by reirradiation using different techniques. Both gold grain implantation (GGI) and stereotactic radiosurgery (SRS) have been used as salvage treatment of NPC but the relative efficacy of these two treatments is not known. Methods and Materials: A total of 74 patients with local NPC failure were included in this retrospective analysis. Of these patients, 37 underwent SRS (median dose, 12.5 Gy) and 37 split-palatal GGI at a dose of 60 Gy. The two groups were individually matched for prognostic factors, except for tumor volume. The median follow-up was 42 months. Results: Local control was better in the GGI group. The 3-year local failure-free rate was 77.9% for the GGI group compared with 68.3% for the SRS group. However, the difference was not statistically significant (p = 0.098). In the subgroup with a tumor volume of &#8804;5 cm 3, the 3-year local failure-free rates were similar, with 79.3% in the GGI group and 72.4% in the SRS group. Neuroendocrine complications were more common in the SRS group, and headache and fistula were more common in the GGI group. Conclusion: Stereotactic radiosurgery and GGI are both effective salvage treatment for NPC. In patients with limited local failure, both yielded comparable high tumor control rates. &#169; 2007 Elsevier Inc. All rights reserved.</description.abstract>
<language>eng</language>
<publisher>Elsevier Inc. The Journal&apos;s web site is located at http://www.elsevier.com/locate/ijrobp</publisher>
<relation.ispartof>International Journal of Radiation Oncology Biology Physics</relation.ispartof>
<rights>International Journal of Radiation: Oncology - Biology - Physics. Copyright &#169; Elsevier Inc.</rights>
<subject>Gold grain implantation</subject>
<subject>Local failure</subject>
<subject>Nasopharyngeal carcinoma</subject>
<subject>Stereotactic radiosurgery</subject>
<title>Stereotactic Radiosurgery Versus Gold Grain Implantation in Salvaging Local Failures of Nasopharyngeal Carcinoma</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0360-3016&amp;volume=69&amp;spage=469&amp;epage=74&amp;date=2007&amp;atitle=Stereotactic+radiosurgery+versus+gold+grain+implantation+in+salvaging+local+failures+of+nasopharyngeal+carcinoma</identifier.openurl>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1016/j.ijrobp.2007.03.012</identifier.doi>
<identifier.pmid>17869663</identifier.pmid>
<identifier.scopus>eid_2-s2.0-34548522202</identifier.scopus>
<identifier.hkuros>139674</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-34548522202&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>69</identifier.volume>
<identifier.issue>2</identifier.issue>
<identifier.spage>469</identifier.spage>
<identifier.epage>474</identifier.epage>
<identifier.isi>WOS:000249796100021</identifier.isi>
<publisher.place>United States</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong