Article: Stereotactic Radiosurgery Versus Gold Grain Implantation in Salvaging Local Failures of Nasopharyngeal Carcinoma

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TitleStereotactic Radiosurgery Versus Gold Grain Implantation in Salvaging Local Failures of Nasopharyngeal Carcinoma
AuthorsChua, DTT1
Wei, WI1
Sham, JST1
Hung, KN1
Au, GKH1
KeywordsGold grain implantation
Local failure
Nasopharyngeal carcinoma
Stereotactic radiosurgery
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
CitationInternational Journal Of Radiation Oncology Biology Physics, 2007, v. 69 n. 2, p. 469-474 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijrobp.2007.03.012
AbstractBackground: Limited local failure of nasopharyngeal carcinoma (NPC) can often be salvaged by reirradiation using different techniques. Both gold grain implantation (GGI) and stereotactic radiosurgery (SRS) have been used as salvage treatment of NPC but the relative efficacy of these two treatments is not known. Methods and Materials: A total of 74 patients with local NPC failure were included in this retrospective analysis. Of these patients, 37 underwent SRS (median dose, 12.5 Gy) and 37 split-palatal GGI at a dose of 60 Gy. The two groups were individually matched for prognostic factors, except for tumor volume. The median follow-up was 42 months. Results: Local control was better in the GGI group. The 3-year local failure-free rate was 77.9% for the GGI group compared with 68.3% for the SRS group. However, the difference was not statistically significant (p = 0.098). In the subgroup with a tumor volume of ≤5 cm 3, the 3-year local failure-free rates were similar, with 79.3% in the GGI group and 72.4% in the SRS group. Neuroendocrine complications were more common in the SRS group, and headache and fistula were more common in the GGI group. Conclusion: Stereotactic radiosurgery and GGI are both effective salvage treatment for NPC. In patients with limited local failure, both yielded comparable high tumor control rates. © 2007 Elsevier Inc. All rights reserved.
ISSN0360-3016
2011 Impact Factor: 4.105
2011 SCImago Journal Rankings: 0.402
DOIhttp://dx.doi.org/10.1016/j.ijrobp.2007.03.012
ISI Accession Number IDWOS:000249796100021
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChua, DTT
dc.contributor.authorWei, WI
dc.contributor.authorSham, JST
dc.contributor.authorHung, KN
dc.contributor.authorAu, GKH
dc.date.accessioned2010-09-06T08:48:23Z
dc.date.available2010-09-06T08:48:23Z
dc.date.issued2007
dc.description.abstractBackground: Limited local failure of nasopharyngeal carcinoma (NPC) can often be salvaged by reirradiation using different techniques. Both gold grain implantation (GGI) and stereotactic radiosurgery (SRS) have been used as salvage treatment of NPC but the relative efficacy of these two treatments is not known. Methods and Materials: A total of 74 patients with local NPC failure were included in this retrospective analysis. Of these patients, 37 underwent SRS (median dose, 12.5 Gy) and 37 split-palatal GGI at a dose of 60 Gy. The two groups were individually matched for prognostic factors, except for tumor volume. The median follow-up was 42 months. Results: Local control was better in the GGI group. The 3-year local failure-free rate was 77.9% for the GGI group compared with 68.3% for the SRS group. However, the difference was not statistically significant (p = 0.098). In the subgroup with a tumor volume of ≤5 cm 3, the 3-year local failure-free rates were similar, with 79.3% in the GGI group and 72.4% in the SRS group. Neuroendocrine complications were more common in the SRS group, and headache and fistula were more common in the GGI group. Conclusion: Stereotactic radiosurgery and GGI are both effective salvage treatment for NPC. In patients with limited local failure, both yielded comparable high tumor control rates. © 2007 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationInternational Journal Of Radiation Oncology Biology Physics, 2007, v. 69 n. 2, p. 469-474 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijrobp.2007.03.012
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijrobp.2007.03.012
dc.identifier.epage474
dc.identifier.hkuros139674
dc.identifier.isiWOS:000249796100021
dc.identifier.issn0360-3016
2011 Impact Factor: 4.105
2011 SCImago Journal Rankings: 0.402
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmid17869663
dc.identifier.scopuseid_2-s2.0-34548522202
dc.identifier.spage469
dc.identifier.urihttp://hdl.handle.net/10722/84054
dc.identifier.volume69
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
dc.publisher.placeUnited States
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physics
dc.relation.referencesReferences in Scopus
dc.rightsInternational Journal of Radiation: Oncology - Biology - Physics. Copyright © Elsevier Inc.
dc.subjectGold grain implantation
dc.subjectLocal failure
dc.subjectNasopharyngeal carcinoma
dc.subjectStereotactic radiosurgery
dc.titleStereotactic Radiosurgery Versus Gold Grain Implantation in Salvaging Local Failures of Nasopharyngeal Carcinoma
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong