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Article: Idiopathic slow transit constipation and megacolon are not associated with neurturin mutations

TitleIdiopathic slow transit constipation and megacolon are not associated with neurturin mutations
Authors
Issue Date2002
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NMO
Citation
Neurogastroenterology and Motility, 2002, v. 14 n. 5, p. 513-517 How to Cite?
AbstractChronic Idiopathic Slow-Transit Constipation (Istc) And Idiopathic Megacolon (Imc) Are Early-Onset Gastrointestinal Motility Disorders Of Unknown Aetiology. The Gene Encoding The Neurotrophic Factor Neurturin May Be A Candidate For These Disorders, As Neurturin-Deficient Mice Have A Similar Enteric Phenotype. In The Present Study, We Tested This Hypothesis. Genomic Dna From 26 Cases Of Chronic Idiopathic Stc [With A Family History Of Constipation In 15 (58%) And Hirschsprung's Disease In Two (8%)], And Five Cases Of Imc [Two Familial (40%)] Was Screened By Direct Dna Sequencing Using The Fluorescent Dideoxy Terminator Method. Results Were Compared With Published Sequence Data And 24 Control Dnas. Our Results Revealed Several Previously Unreported Common Sequence Polymorphisms, But Overall Frequencies Were Comparable Between Patients And Controls. We Conclude That Mutation Of Neurturin Is Not A Frequent Cause Of Istc Or Imc.
Persistent Identifierhttp://hdl.handle.net/10722/84034
ISSN
2015 Impact Factor: 3.31
2015 SCImago Journal Rankings: 1.722
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, BLSen_HK
dc.contributor.authorKnowles, CHen_HK
dc.contributor.authorScott, Men_HK
dc.contributor.authorAnand, Pen_HK
dc.contributor.authorWilliams, NSen_HK
dc.contributor.authorMilbrandt, Jen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T08:48:08Z-
dc.date.available2010-09-06T08:48:08Z-
dc.date.issued2002en_HK
dc.identifier.citationNeurogastroenterology and Motility, 2002, v. 14 n. 5, p. 513-517en_HK
dc.identifier.issn1350-1925en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84034-
dc.description.abstractChronic Idiopathic Slow-Transit Constipation (Istc) And Idiopathic Megacolon (Imc) Are Early-Onset Gastrointestinal Motility Disorders Of Unknown Aetiology. The Gene Encoding The Neurotrophic Factor Neurturin May Be A Candidate For These Disorders, As Neurturin-Deficient Mice Have A Similar Enteric Phenotype. In The Present Study, We Tested This Hypothesis. Genomic Dna From 26 Cases Of Chronic Idiopathic Stc [With A Family History Of Constipation In 15 (58%) And Hirschsprung's Disease In Two (8%)], And Five Cases Of Imc [Two Familial (40%)] Was Screened By Direct Dna Sequencing Using The Fluorescent Dideoxy Terminator Method. Results Were Compared With Published Sequence Data And 24 Control Dnas. Our Results Revealed Several Previously Unreported Common Sequence Polymorphisms, But Overall Frequencies Were Comparable Between Patients And Controls. We Conclude That Mutation Of Neurturin Is Not A Frequent Cause Of Istc Or Imc.en_US
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NMOen_HK
dc.relation.ispartofNeurogastroenterology and Motilityen_HK
dc.rightsNeurogastroenterology and Motility. Copyright © Blackwell Publishing Ltd.en_HK
dc.titleIdiopathic slow transit constipation and megacolon are not associated with neurturin mutationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1350-1925&volume=14 &issue=5&spage=513&epage=517&date=2002&atitle=Idiopathic+slow+transit+constipation+and+megacolon+are+not+associated+with+neurturin+mutationsen_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2982.2002.00354.xen_US
dc.identifier.pmid12358679-
dc.identifier.scopuseid_2-s2.0-0036403029en_US
dc.identifier.hkuros75800en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036403029&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue5en_US
dc.identifier.spage513en_US
dc.identifier.epage517en_US
dc.identifier.isiWOS:000178344800006-

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