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Article: Mapping of nasopharyngeal carcinoma tumor-suppressive activity to a 1.8-Megabase region of chromosome band 11q13

TitleMapping of nasopharyngeal carcinoma tumor-suppressive activity to a 1.8-Megabase region of chromosome band 11q13
Authors
Issue Date2002
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250
Citation
Genes Chromosomes And Cancer, 2002, v. 34 n. 1, p. 97-103 How to Cite?
AbstractNasopharyngeal carcinoma (NPC) is a malignancy that is particularly prevalent among populations from Southern China and Southeast Asian countries. Evidence for a genetic contribution to the disease has been documented, although the genetic basis for NPC development is not yet fully understood. Previous functional evidence of tumor-suppressive activity on chromosome band 11q13 in NPC was obtained using a microcell-mediated chromosome-transfer approach with HONE1 NPC cells. In the present study, this region was subjected to a detailed investigation of microcell hybrids and their tumor segregants using microsatellite analysis to narrow down the region of tumor-suppressive activity. Fluorescence in situ hybridization was also performed with BAC and cosmid probes to confirm the microsatellite data. The critical region responsible for tumor suppression was narrowed down to a 1.8-Mb interval, which does not tolerate an additional normal allele by chromosome transfer. One or two alleles from either endogenous or exogenous chromosomes at 11q13 were consistently eliminated during tumor growth. Results of this study suggest that a candidate tumor-suppressor gene, not the MEN1 gene, maps between D11S4907 and GSTP1 in NPC. © 2002 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/84004
ISSN
2015 Impact Factor: 3.96
2015 SCImago Journal Rankings: 2.210
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, Yen_HK
dc.contributor.authorChakrabarti, Ren_HK
dc.contributor.authorGarciaBarcelo, Men_HK
dc.contributor.authorHa, TJen_HK
dc.contributor.authorSrivatsan, ESen_HK
dc.contributor.authorStanbridge, EJen_HK
dc.contributor.authorLung, MLen_HK
dc.date.accessioned2010-09-06T08:47:47Z-
dc.date.available2010-09-06T08:47:47Z-
dc.date.issued2002en_HK
dc.identifier.citationGenes Chromosomes And Cancer, 2002, v. 34 n. 1, p. 97-103en_HK
dc.identifier.issn1045-2257en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84004-
dc.description.abstractNasopharyngeal carcinoma (NPC) is a malignancy that is particularly prevalent among populations from Southern China and Southeast Asian countries. Evidence for a genetic contribution to the disease has been documented, although the genetic basis for NPC development is not yet fully understood. Previous functional evidence of tumor-suppressive activity on chromosome band 11q13 in NPC was obtained using a microcell-mediated chromosome-transfer approach with HONE1 NPC cells. In the present study, this region was subjected to a detailed investigation of microcell hybrids and their tumor segregants using microsatellite analysis to narrow down the region of tumor-suppressive activity. Fluorescence in situ hybridization was also performed with BAC and cosmid probes to confirm the microsatellite data. The critical region responsible for tumor suppression was narrowed down to a 1.8-Mb interval, which does not tolerate an additional normal allele by chromosome transfer. One or two alleles from either endogenous or exogenous chromosomes at 11q13 were consistently eliminated during tumor growth. Results of this study suggest that a candidate tumor-suppressor gene, not the MEN1 gene, maps between D11S4907 and GSTP1 in NPC. © 2002 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250en_HK
dc.relation.ispartofGenes Chromosomes and Canceren_HK
dc.rightsGenes, Chromosomes & Cancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshChromosome Mapping - methods-
dc.subject.meshChromosomes, Human, Pair 11 - genetics-
dc.subject.meshGenes, Tumor Suppressor-
dc.subject.meshGenetic Markers - genetics-
dc.subject.meshNasopharyngeal Neoplasms - genetics-
dc.titleMapping of nasopharyngeal carcinoma tumor-suppressive activity to a 1.8-Megabase region of chromosome band 11q13en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1045-2257&volume=34&issue=1&spage=97&epage=103&date=2002&atitle=Mapping+of+nasopharyngeal+carcinoma+tumor-suppressive+activity+to+a+1.8-megabase+region+of+chromosome+band+11q13en_HK
dc.identifier.emailCheng, Y: yuecheng@hku.hken_HK
dc.identifier.emailGarciaBarcelo, M: mmgarcia@hkucc.hku.hken_HK
dc.identifier.emailLung, ML: mlilung@hku.hken_HK
dc.identifier.authorityCheng, Y=rp01320en_HK
dc.identifier.authorityGarciaBarcelo, M=rp00445en_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/gcc.10048en_HK
dc.identifier.pmid11921287en_HK
dc.identifier.scopuseid_2-s2.0-0036204112en_HK
dc.identifier.hkuros79176en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036204112&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue1en_HK
dc.identifier.spage97en_HK
dc.identifier.epage103en_HK
dc.identifier.isiWOS:000174537700012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, Y=36131038300en_HK
dc.identifier.scopusauthoridChakrabarti, R=7102638262en_HK
dc.identifier.scopusauthoridGarciaBarcelo, M=6701767303en_HK
dc.identifier.scopusauthoridHa, TJ=23103098800en_HK
dc.identifier.scopusauthoridSrivatsan, ES=7004357040en_HK
dc.identifier.scopusauthoridStanbridge, EJ=7103249410en_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK

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