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Article: Submucosal tumor extension in hypopharyngeal cancer

TitleSubmucosal tumor extension in hypopharyngeal cancer
Authors
Issue Date1997
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archoto.com
Citation
Archives Of Otolaryngology - Head And Neck Surgery, 1997, v. 123 n. 9, p. 959-965 How to Cite?
AbstractObjectives: To study the incidence and extent of submucosal tumor extension in hypopharyngeal cancer and to evaluate the impact on the tumor recurrence and overall survival rates. Method: Fifty-seven resected specimens of hypopharyngeal cancer were studied in detail from January 1986 to December 1989 by use of the whole-organ, step-serial sectioning technique. Results: Three types of submucosal tumor extension could be identified. Type I extension was characterized by a tumor with a smooth round contour that extended submucosally. The mucosa was thereby elevated and was detectable on gross inspection at operation. In type II extension, tongues and islands of tumor infiltrated within the submucosa, and these were not noticeable on gross examination. Skip metastasis in the submucosa where the submucosal tumor was completely separated from the main tumor bulk was classified as type III extension. Thirty-three patients (58%) had submucosal tumor ex tension. The frequencies (and extents of submucosal tumor extension) in the superior, medial, lateral, and inferior directions were 16% (3-10 mm), 37% (2-37 mm). 26% (2-37 mm), and 28% C3-35 mm), respectively. Two thirds of the submucosal extension was type I (22 of 33), and only i patient had a true skip lesion submucosally (type III extension). Type II submucosal extension was found in one third of the patients (11 of 33). This occurred significantly more often in the patients who had received radiotherapy before surgery (82% [9/11]; P<.001; 95% confidence interval, 1.28-4.44). The presence of submucosal tumor extension had no effect on the tumor recurrence and overall survival rates. Conclusions: The incidence of submucosal tumor extensions in hypopharyngeal cancer is high (58%), but most (67%) of them can be detected grossly at operation. The presence of submucosal tumor extension does not adversely affect the survival and tumor recurrence rates.
Persistent Identifierhttp://hdl.handle.net/10722/84002
ISSN
2014 Impact Factor: 2.327
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, CMen_HK
dc.contributor.authorNg, WFen_HK
dc.contributor.authorLam, KHen_HK
dc.contributor.authorWei, WIen_HK
dc.contributor.authorYuen, APWen_HK
dc.date.accessioned2010-09-06T08:47:46Z-
dc.date.available2010-09-06T08:47:46Z-
dc.date.issued1997en_HK
dc.identifier.citationArchives Of Otolaryngology - Head And Neck Surgery, 1997, v. 123 n. 9, p. 959-965en_HK
dc.identifier.issn0886-4470en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84002-
dc.description.abstractObjectives: To study the incidence and extent of submucosal tumor extension in hypopharyngeal cancer and to evaluate the impact on the tumor recurrence and overall survival rates. Method: Fifty-seven resected specimens of hypopharyngeal cancer were studied in detail from January 1986 to December 1989 by use of the whole-organ, step-serial sectioning technique. Results: Three types of submucosal tumor extension could be identified. Type I extension was characterized by a tumor with a smooth round contour that extended submucosally. The mucosa was thereby elevated and was detectable on gross inspection at operation. In type II extension, tongues and islands of tumor infiltrated within the submucosa, and these were not noticeable on gross examination. Skip metastasis in the submucosa where the submucosal tumor was completely separated from the main tumor bulk was classified as type III extension. Thirty-three patients (58%) had submucosal tumor ex tension. The frequencies (and extents of submucosal tumor extension) in the superior, medial, lateral, and inferior directions were 16% (3-10 mm), 37% (2-37 mm). 26% (2-37 mm), and 28% C3-35 mm), respectively. Two thirds of the submucosal extension was type I (22 of 33), and only i patient had a true skip lesion submucosally (type III extension). Type II submucosal extension was found in one third of the patients (11 of 33). This occurred significantly more often in the patients who had received radiotherapy before surgery (82% [9/11]; P<.001; 95% confidence interval, 1.28-4.44). The presence of submucosal tumor extension had no effect on the tumor recurrence and overall survival rates. Conclusions: The incidence of submucosal tumor extensions in hypopharyngeal cancer is high (58%), but most (67%) of them can be detected grossly at operation. The presence of submucosal tumor extension does not adversely affect the survival and tumor recurrence rates.en_HK
dc.languageengen_HK
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archoto.comen_HK
dc.relation.ispartofArchives of Otolaryngology - Head and Neck Surgeryen_HK
dc.titleSubmucosal tumor extension in hypopharyngeal canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0886-4470&volume=123&spage=959&epage=965&date=1997&atitle=Submucosal+tumor+extension+in+hypopharyngeal+canceren_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9305246en_HK
dc.identifier.scopuseid_2-s2.0-0030931873en_HK
dc.identifier.hkuros31091en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030931873&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume123en_HK
dc.identifier.issue9en_HK
dc.identifier.spage959en_HK
dc.identifier.epage965en_HK
dc.identifier.isiWOS:A1997XX18900009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, CM=7404652540en_HK
dc.identifier.scopusauthoridNg, WF=25940213100en_HK
dc.identifier.scopusauthoridLam, KH=7403657342en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.scopusauthoridYuen, APW=7006290111en_HK

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