File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Craniofacial resection for malignant paranasal sinus tumors: Report of an international collaborative study

TitleCraniofacial resection for malignant paranasal sinus tumors: Report of an international collaborative study
Authors
KeywordsCraniofacial resection
Paranasal sinus neoplasms
Issue Date2005
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
Citation
Head And Neck, 2005, v. 27 n. 7, p. 575-584 How to Cite?
AbstractBackground. Malignant tumors of the superior sinonasal vault are rare, and, because of this and the varied histologic findings, most outcomes data reflect the experience of small patient cohorts. This International Collaborative study examines a large cohort of patients accumulated from multiple institutions experienced in craniofacial surgery, with the aim of reporting benchmark figures for outcomes and identifying patient-related and tumor-related predictors of prognosis after craniofacial resection (CFR). Methods. Three hundred thirty-four patients from 17 institutions were analyzed for outcome. Patients with esthesioneuroblastoma were excluded and are being reported separately. The median age was 57 years (range, 3-98 years). One hundred eighty-eight patients (56.3%) had had prior single-modality or combined treatment, which included surgery in 120 (36%), radiation in 79 (23.7%), and chemotherapy in 56 (16.8%). The most common histologic findings were adenocarcinoma in 107 (32%) and squamous cell carcinoma in 101 (30.2%). The margins of resection were close or microscopically positive in 95 (30%). Adjuvant radiotherapy was given in 161 (48.2%) and chemotherapy in 16 (4.8%). Statistical analyses for outcomes were performed in relation to patient characteristics, tumor characteristics, including histologic findings and extent of disease surgical resection margins, prior radiation, and prior chemotherapy to determine predictive factors. Results. Postoperative mortality occurred in 15 patients (4.5%). Postoperative complications occurred in 110 patients (32.9%). The 5-year overall, disease-specific, and recurrence-free survival rates were 48.3%, 53.3%, and 45.8%, respectively The status of surgical margins, histologic findings of the primary tumor, and intracranial extent were independent predictors of overall, disease-specific, and recurrence-free survival on multivariate analysis. Conclusions. CFR for malignant paranasal sinus tumors is a safe surgical treatment with an overall mortality of 4.5% and complication rate of 33%. The status of surgical margins, histologic findings of the primary tumor, and intracranial extent are independent predictors of outcome. © 2005 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/83992
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGanly, Ien_HK
dc.contributor.authorPatel, SGen_HK
dc.contributor.authorSingh, Ben_HK
dc.contributor.authorKraus, DHen_HK
dc.contributor.authorBridger, PGen_HK
dc.contributor.authorCantu, Gen_HK
dc.contributor.authorCheesman, Aen_HK
dc.contributor.authorDe Sa, Gen_HK
dc.contributor.authorDonald, Pen_HK
dc.contributor.authorFliss, DMen_HK
dc.contributor.authorGullane, Pen_HK
dc.contributor.authorJanecka, Ien_HK
dc.contributor.authorKamata, SEen_HK
dc.contributor.authorKowalski, LPen_HK
dc.contributor.authorLevine, PAen_HK
dc.contributor.authorMedina Dos Santos, LRen_HK
dc.contributor.authorPradhan, Sen_HK
dc.contributor.authorSchramm, Ven_HK
dc.contributor.authorSnyderman, Cen_HK
dc.contributor.authorWei, WIen_HK
dc.contributor.authorShah, JPen_HK
dc.date.accessioned2010-09-06T08:47:38Z-
dc.date.available2010-09-06T08:47:38Z-
dc.date.issued2005en_HK
dc.identifier.citationHead And Neck, 2005, v. 27 n. 7, p. 575-584en_HK
dc.identifier.issn1043-3074en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83992-
dc.description.abstractBackground. Malignant tumors of the superior sinonasal vault are rare, and, because of this and the varied histologic findings, most outcomes data reflect the experience of small patient cohorts. This International Collaborative study examines a large cohort of patients accumulated from multiple institutions experienced in craniofacial surgery, with the aim of reporting benchmark figures for outcomes and identifying patient-related and tumor-related predictors of prognosis after craniofacial resection (CFR). Methods. Three hundred thirty-four patients from 17 institutions were analyzed for outcome. Patients with esthesioneuroblastoma were excluded and are being reported separately. The median age was 57 years (range, 3-98 years). One hundred eighty-eight patients (56.3%) had had prior single-modality or combined treatment, which included surgery in 120 (36%), radiation in 79 (23.7%), and chemotherapy in 56 (16.8%). The most common histologic findings were adenocarcinoma in 107 (32%) and squamous cell carcinoma in 101 (30.2%). The margins of resection were close or microscopically positive in 95 (30%). Adjuvant radiotherapy was given in 161 (48.2%) and chemotherapy in 16 (4.8%). Statistical analyses for outcomes were performed in relation to patient characteristics, tumor characteristics, including histologic findings and extent of disease surgical resection margins, prior radiation, and prior chemotherapy to determine predictive factors. Results. Postoperative mortality occurred in 15 patients (4.5%). Postoperative complications occurred in 110 patients (32.9%). The 5-year overall, disease-specific, and recurrence-free survival rates were 48.3%, 53.3%, and 45.8%, respectively The status of surgical margins, histologic findings of the primary tumor, and intracranial extent were independent predictors of overall, disease-specific, and recurrence-free survival on multivariate analysis. Conclusions. CFR for malignant paranasal sinus tumors is a safe surgical treatment with an overall mortality of 4.5% and complication rate of 33%. The status of surgical margins, histologic findings of the primary tumor, and intracranial extent are independent predictors of outcome. © 2005 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137en_HK
dc.relation.ispartofHead and Necken_HK
dc.subjectCraniofacial resectionen_HK
dc.subjectParanasal sinus neoplasmsen_HK
dc.titleCraniofacial resection for malignant paranasal sinus tumors: Report of an international collaborative studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0017-8748&volume=27&spage=575&epage=584&date=2005&atitle=Craniofacial+resection+for+malignant+paranasal+sinus+tumors:+Report+of+an+International+Collaborative+Studyen_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hed.20165en_HK
dc.identifier.pmid15825201-
dc.identifier.scopuseid_2-s2.0-21844436072en_HK
dc.identifier.hkuros103730en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21844436072&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue7en_HK
dc.identifier.spage575en_HK
dc.identifier.epage584en_HK
dc.identifier.isiWOS:000230242200004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGanly, I=6701500102en_HK
dc.identifier.scopusauthoridPatel, SG=7403903141en_HK
dc.identifier.scopusauthoridSingh, B=7405639360en_HK
dc.identifier.scopusauthoridKraus, DH=25947461900en_HK
dc.identifier.scopusauthoridBridger, PG=6603845621en_HK
dc.identifier.scopusauthoridCantu, G=7003498793en_HK
dc.identifier.scopusauthoridCheesman, A=7003676128en_HK
dc.identifier.scopusauthoridDe Sa, G=8561754500en_HK
dc.identifier.scopusauthoridDonald, P=7103189603en_HK
dc.identifier.scopusauthoridFliss, DM=7005455625en_HK
dc.identifier.scopusauthoridGullane, P=7005484642en_HK
dc.identifier.scopusauthoridJanecka, I=7005569375en_HK
dc.identifier.scopusauthoridKamata, SE=35478208000en_HK
dc.identifier.scopusauthoridKowalski, LP=7102126040en_HK
dc.identifier.scopusauthoridLevine, PA=35386674700en_HK
dc.identifier.scopusauthoridMedina Dos Santos, LR=6505883858en_HK
dc.identifier.scopusauthoridPradhan, S=7202877432en_HK
dc.identifier.scopusauthoridSchramm, V=35511790400en_HK
dc.identifier.scopusauthoridSnyderman, C=7005989580en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.scopusauthoridShah, JP=7403266008en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats