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Article: Plasma fibrinogen level: An independent risk factor for long-term survival in Chinese patients with peripheral artery disease?

TitlePlasma fibrinogen level: An independent risk factor for long-term survival in Chinese patients with peripheral artery disease?
Authors
Issue Date2005
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/
Citation
World Journal Of Surgery, 2005, v. 29 n. 10, p. 1263-1267 How to Cite?
AbstractFibrinogen, an inflammatory marker as well as a fundamental part of the coagulation cascade, is suggested to play a significant role in the pathogenesis of atherosclerosis and complications of atherothrombotic diseases. The aim of this study was to determine if plasma fibrinogen is an independent risk factor for long-term survival in patients with peripheral artery disease (PAD). Altogether, 139 Chinese patients (88 men, 51 women) with PAD were consecutively recruited for the study. Atherothrombotic risk factors and fibrinogen levels were determined at presentation, and all patients were followed up for mortality prospectively. The mean follow-up was 6 years. All variables were first correlated with survival rates using Kaplan-Meier analysis and compared by means of the log-rank test. Significant risk factors were identified, and multivariate Cox regression analysis was used to evaluate the independent contribution of the fibrinogen level to the risk of mortality. During follow-up, 95 patients (68.3%) died. The overall survival rate was 77.7% at 3 years, 56.8% at 5 years, and 31.2% at 10 years (standard errors 0.05, 0.06, and 0.07, respectively). All-cause mortality rate increased with an elevated fibrinogen level. Eighty percent of patients with a fibrinogen level > 3.4 g/L had a survival time of less than 3 years (p = 0.002). This relation was also demonstrated within patients with critical ischemia. The plasma fibrinogen level was thus identified as an independent risk factor for mortality in PAD patients after adjusting for confounding factors. © 2005 by the Société Internationale de Chirurgie.
Persistent Identifierhttp://hdl.handle.net/10722/83969
ISSN
2015 Impact Factor: 2.523
2015 SCImago Journal Rankings: 1.375
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheuk, BLYen_HK
dc.contributor.authorCheung, GCYen_HK
dc.contributor.authorLau, SSFen_HK
dc.contributor.authorCheng, SWKen_HK
dc.date.accessioned2010-09-06T08:47:22Z-
dc.date.available2010-09-06T08:47:22Z-
dc.date.issued2005en_HK
dc.identifier.citationWorld Journal Of Surgery, 2005, v. 29 n. 10, p. 1263-1267en_HK
dc.identifier.issn0364-2313en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83969-
dc.description.abstractFibrinogen, an inflammatory marker as well as a fundamental part of the coagulation cascade, is suggested to play a significant role in the pathogenesis of atherosclerosis and complications of atherothrombotic diseases. The aim of this study was to determine if plasma fibrinogen is an independent risk factor for long-term survival in patients with peripheral artery disease (PAD). Altogether, 139 Chinese patients (88 men, 51 women) with PAD were consecutively recruited for the study. Atherothrombotic risk factors and fibrinogen levels were determined at presentation, and all patients were followed up for mortality prospectively. The mean follow-up was 6 years. All variables were first correlated with survival rates using Kaplan-Meier analysis and compared by means of the log-rank test. Significant risk factors were identified, and multivariate Cox regression analysis was used to evaluate the independent contribution of the fibrinogen level to the risk of mortality. During follow-up, 95 patients (68.3%) died. The overall survival rate was 77.7% at 3 years, 56.8% at 5 years, and 31.2% at 10 years (standard errors 0.05, 0.06, and 0.07, respectively). All-cause mortality rate increased with an elevated fibrinogen level. Eighty percent of patients with a fibrinogen level > 3.4 g/L had a survival time of less than 3 years (p = 0.002). This relation was also demonstrated within patients with critical ischemia. The plasma fibrinogen level was thus identified as an independent risk factor for mortality in PAD patients after adjusting for confounding factors. © 2005 by the Société Internationale de Chirurgie.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/en_HK
dc.relation.ispartofWorld Journal of Surgeryen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAtherosclerosis - blood - complications - mortalityen_HK
dc.subject.meshBiological Markers - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFibrinogen - analysisen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPeripheral Vascular Diseases - blood - etiology - mortalityen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSurvival Analysisen_HK
dc.titlePlasma fibrinogen level: An independent risk factor for long-term survival in Chinese patients with peripheral artery disease?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0364-2313&volume=29&spage=1263&epage=1267&date=2005&atitle=Plasma+fibrinogen+level:+an+independent+risk+factor+for+long-term+survival+in+Chinese+patients+with+peripheral+artery+disease?en_HK
dc.identifier.emailCheuk, BLY: bernice@hku.hken_HK
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hken_HK
dc.identifier.authorityCheuk, BLY=rp01671en_HK
dc.identifier.authorityCheng, SWK=rp00374en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00268-005-7802-4en_HK
dc.identifier.pmid16158212-
dc.identifier.scopuseid_2-s2.0-27744445670en_HK
dc.identifier.hkuros114476en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27744445670&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1263en_HK
dc.identifier.epage1267en_HK
dc.identifier.isiWOS:000232494800012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheuk, BLY=7801343617en_HK
dc.identifier.scopusauthoridCheung, GCY=15052803300en_HK
dc.identifier.scopusauthoridLau, SSF=9234106700en_HK
dc.identifier.scopusauthoridCheng, SWK=7404684779en_HK

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