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Article: Prokineticin-signaling pathway

TitleProkineticin-signaling pathway
Authors
Issue Date2008
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/biocel
Citation
The International Journal of Biochemistry & Cell Biology, 2008, v. 40 n. 9, p. 1679–1684 How to Cite?
AbstractProkineticin signaling comprises two secreted proteins (Prok-1 and Prok-2) and two cognate G-protein coupled receptors (PK-R1 and PK-R2) that are widely expressed in different tissues and of great versatility. Prokineticins were originally identified as the potent agents mediating gut motility in the digestive system, but were later shown to promote angiogenesis in steroidgenic glands, heart and reproductive organs. Prokineticins also modulate neurogenesis, circadian rhythms, nociception, haematopoiesis as well as immune response. Their diverse biological functions and functional complexity are exquisitely mediated by the distinct expression pattern and the multiple G-protein coupling of the receptors and ligands. Emerging evidence indicated that prokineticins are also associated with pathologies of the reproductive and nervous systems, myocardial infarction and tumorigenesis. The physiological and patho-physiological roles of prokineticin signaling are just beginning to be revealed and a better understanding of the system should lead to the development of useful therapies for various diseases.
Persistent Identifierhttp://hdl.handle.net/10722/83961
ISSN
2015 Impact Factor: 3.905
2015 SCImago Journal Rankings: 2.003
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNgan, ESWen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T08:47:16Z-
dc.date.available2010-09-06T08:47:16Z-
dc.date.issued2008en_HK
dc.identifier.citationThe International Journal of Biochemistry & Cell Biology, 2008, v. 40 n. 9, p. 1679–1684en_HK
dc.identifier.issn1357-2725-
dc.identifier.urihttp://hdl.handle.net/10722/83961-
dc.description.abstractProkineticin signaling comprises two secreted proteins (Prok-1 and Prok-2) and two cognate G-protein coupled receptors (PK-R1 and PK-R2) that are widely expressed in different tissues and of great versatility. Prokineticins were originally identified as the potent agents mediating gut motility in the digestive system, but were later shown to promote angiogenesis in steroidgenic glands, heart and reproductive organs. Prokineticins also modulate neurogenesis, circadian rhythms, nociception, haematopoiesis as well as immune response. Their diverse biological functions and functional complexity are exquisitely mediated by the distinct expression pattern and the multiple G-protein coupling of the receptors and ligands. Emerging evidence indicated that prokineticins are also associated with pathologies of the reproductive and nervous systems, myocardial infarction and tumorigenesis. The physiological and patho-physiological roles of prokineticin signaling are just beginning to be revealed and a better understanding of the system should lead to the development of useful therapies for various diseases.-
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/biocel-
dc.relation.ispartofThe International Journal of Biochemistry & Cell Biologyen_HK
dc.subject.meshHirschsprung Disease - metabolism-
dc.subject.meshKallmann Syndrome - metabolism-
dc.subject.meshNeoplasms - metabolism-
dc.subject.meshSignal Transduction-
dc.subject.meshVascular Endothelial Growth Factor, Endocrine-Gland-Derived - metabolism-
dc.titleProkineticin-signaling pathwayen_HK
dc.typeArticleen_HK
dc.identifier.emailNgan, ESW: engan@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityNgan, ESW=rp00422en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biocel.2008.03.010-
dc.identifier.pmid18440852-
dc.identifier.scopuseid_2-s2.0-49949151790-
dc.identifier.hkuros144045en_HK
dc.identifier.volume40-
dc.identifier.issue9-
dc.identifier.spage1679–1684-
dc.identifier.epage1679–1684-
dc.identifier.isiWOS:000258052000008-
dc.publisher.placeUnited Kingdom-

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