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Article: A prospective study of a one-week non- bismuth quadruple therapy for childhood Helicobacter pylori infection

TitleA prospective study of a one-week non- bismuth quadruple therapy for childhood Helicobacter pylori infection
Authors
Issue Date2001
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
Citation
Journal Of Pediatric Surgery, 2001, v. 36 n. 7, p. 1008-1011 How to Cite?
AbstractPurpose: In The Eradication Of Helicobacter Pylori Infection, A 1-Week Therapy Improves Patient Compliance, But Drug Resistance May Limit Its Efficacy. The Effectiveness Of The 1-Week Nonbismouth Quadruple Therapy Was Studied Prospectively In Children With Proven H Pylori Infection In A Population With A High Rate Of Metronidazole Resistance. Methods:All Pediatric Patients Who Presented To Our Institutions With Acute And Chronic Upper Gastrointestinal Conditions Requiring Endoscopy From June 1997 To February 2000 Were Investigated Prospectively For H Pylori Infection. Gastric Biopsy Specimens Were Analyzed With Rapid Urease Test And Histopathology, H Pylori-Positive Children Were Treated With Omeprazole, Clarithromycin, Amoxicillin, And Metronidazole For 7 Days. The Result Of Treatment Was Assessed 1 Month After Treatment With Endoscopy And Biopsy. The Same Treatment Was Repeated For 2 Weeks If H Pylori Was Still Present. In Patients Who Needed A Third Endoscopy, Their Biopsy Specimens Were Cultured To Determine Antibiotic Sensitivity. Results Were Correlated With Patients' Symptoms And Endoscopic Findings. Results: Thirty-Three Children With Acute (Severe Epigastric Pain, N = 14; Gastrointestinal Bleeding, N = 9) And Chronic (Recurrent Abdominal Pain, N = 7; Anemia, N = 3) Conditions Were Treated For H Pylori. Thirty-One (94%) Were Confirmed To Have H Pylori Eradicated By A 1-Week Therapy, Whereas 1 Patient Had Eradication After A Further 2-Week Therapy (3.3%). The Only Unresponsive Patient Had H Pylori Resistant To Both Clarithromycin And Metronidazole. All Ulcers And Erosions Healed After The Eradication Of H Pylori. Three Patients Had Persistent Recurrent Abdominal Pain Despite H Pylori Eradication. Conclusions: The 1-Week Therapy With Omeprazole, Clarithromycin, Amoxicillin, And Metronidazole Is An Effective Treatment Of Hpylori In Children In A Population With A High Incidence Of Metronidazole Resistant Strain Of H Pylori. Peptic Ulcers And Erosions Healed With The Eradication Of The Bacteria. Copyright © 2001 W.B. Saunders Company.
Persistent Identifierhttp://hdl.handle.net/10722/83960
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.802
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KLen_HK
dc.contributor.authorZhou, Hen_HK
dc.contributor.authorNg, DKKen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T08:47:16Z-
dc.date.available2010-09-06T08:47:16Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Pediatric Surgery, 2001, v. 36 n. 7, p. 1008-1011en_US
dc.identifier.issn0022-3468en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83960-
dc.description.abstractPurpose: In The Eradication Of Helicobacter Pylori Infection, A 1-Week Therapy Improves Patient Compliance, But Drug Resistance May Limit Its Efficacy. The Effectiveness Of The 1-Week Nonbismouth Quadruple Therapy Was Studied Prospectively In Children With Proven H Pylori Infection In A Population With A High Rate Of Metronidazole Resistance. Methods:All Pediatric Patients Who Presented To Our Institutions With Acute And Chronic Upper Gastrointestinal Conditions Requiring Endoscopy From June 1997 To February 2000 Were Investigated Prospectively For H Pylori Infection. Gastric Biopsy Specimens Were Analyzed With Rapid Urease Test And Histopathology, H Pylori-Positive Children Were Treated With Omeprazole, Clarithromycin, Amoxicillin, And Metronidazole For 7 Days. The Result Of Treatment Was Assessed 1 Month After Treatment With Endoscopy And Biopsy. The Same Treatment Was Repeated For 2 Weeks If H Pylori Was Still Present. In Patients Who Needed A Third Endoscopy, Their Biopsy Specimens Were Cultured To Determine Antibiotic Sensitivity. Results Were Correlated With Patients' Symptoms And Endoscopic Findings. Results: Thirty-Three Children With Acute (Severe Epigastric Pain, N = 14; Gastrointestinal Bleeding, N = 9) And Chronic (Recurrent Abdominal Pain, N = 7; Anemia, N = 3) Conditions Were Treated For H Pylori. Thirty-One (94%) Were Confirmed To Have H Pylori Eradicated By A 1-Week Therapy, Whereas 1 Patient Had Eradication After A Further 2-Week Therapy (3.3%). The Only Unresponsive Patient Had H Pylori Resistant To Both Clarithromycin And Metronidazole. All Ulcers And Erosions Healed After The Eradication Of H Pylori. Three Patients Had Persistent Recurrent Abdominal Pain Despite H Pylori Eradication. Conclusions: The 1-Week Therapy With Omeprazole, Clarithromycin, Amoxicillin, And Metronidazole Is An Effective Treatment Of Hpylori In Children In A Population With A High Incidence Of Metronidazole Resistant Strain Of H Pylori. Peptic Ulcers And Erosions Healed With The Eradication Of The Bacteria. Copyright © 2001 W.B. Saunders Company.en_US
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurgen_HK
dc.relation.ispartofJournal of Pediatric Surgeryen_HK
dc.titleA prospective study of a one-week non- bismuth quadruple therapy for childhood Helicobacter pylori infectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3468&volume=36&spage=1008&epage=1011&date=2001&atitle=A+prospective+study+of+a+one-week+non-+bismuth+quadruple+therapy+for+childhood+Helicobacter+pylori+infectionen_HK
dc.identifier.emailChan, KL: klchan@HKUCC.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1053/jpsu.2001.24726en_US
dc.identifier.pmid11431766-
dc.identifier.scopuseid_2-s2.0-0034937214en_US
dc.identifier.hkuros61220en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034937214&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume36en_US
dc.identifier.issue7en_US
dc.identifier.spage1008en_US
dc.identifier.epage1011en_US
dc.identifier.isiWOS:000169653400009-

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