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Article: Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B

TitleSignificance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B
Authors
KeywordsLamivudine
Mutant
Prophylaxis
Recurrence
Issue Date2005
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AJT
Citation
American Journal Of Transplantation, 2005, v. 5 n. 8, p. 1893-1900 How to Cite?
AbstractHepatitis B virus (HBV) genotype influences chronic hepatitis B disease profile but its relevance in liver transplantation (LTx) is not known. HBV genotype was identified by direct sequencing from pre-transplant sera of 119 patients who underwent LTx using lamivudine prophylaxis (genotype A,1; B,43; C,74; D,1). The baseline characteristics and outcome of 43 genotype B and 74 genotype C patients were compared. Genotype B patients had significantly more pre-transplant acute flare, worse liver functions and higher model for end-stage liver disease score. Fewer genotype B patients had HBeAg (13% vs. 32%; p = 0.017), but HBV DNA seropositivity (by bDNA assay) was comparable (26% vs. 23%; p = 0.727). The 3-year graft survival was 83% for genotype B and 89% for genotype C (p = 0.2). The rate of HBsAg clearance or seroreversion was the same. The cumulative rate of viral breakthrough due to lamivudine-resistant mutants at 3 years was 4% for genotype B and 21% for genotype C (p = 0.017). Liver biopsy after viral breakthrough showed recurrent hepatitis B in 7 of 10 genotype C patients, including 2 with fibrosing cholestatic hepatitis, and no histologic recurrence in 2 genotype B patients. In conclusion, HBV genotypes B and C are associated with different patterns of end-stage liver diseases that required transplantation, and genotype C may carry a greater risk and severity of recurrence due to lamivudine-resistant mutants. Copyright © Blackwell Munksgaard 2005.
Persistent Identifierhttp://hdl.handle.net/10722/83959
ISSN
2015 Impact Factor: 5.669
2015 SCImago Journal Rankings: 2.792
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLo, CMen_HK
dc.contributor.authorCheung, CKen_HK
dc.contributor.authorLau, GKen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorLiu, CLen_HK
dc.contributor.authorChan, SCen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:47:15Z-
dc.date.available2010-09-06T08:47:15Z-
dc.date.issued2005en_HK
dc.identifier.citationAmerican Journal Of Transplantation, 2005, v. 5 n. 8, p. 1893-1900en_HK
dc.identifier.issn1600-6135en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83959-
dc.description.abstractHepatitis B virus (HBV) genotype influences chronic hepatitis B disease profile but its relevance in liver transplantation (LTx) is not known. HBV genotype was identified by direct sequencing from pre-transplant sera of 119 patients who underwent LTx using lamivudine prophylaxis (genotype A,1; B,43; C,74; D,1). The baseline characteristics and outcome of 43 genotype B and 74 genotype C patients were compared. Genotype B patients had significantly more pre-transplant acute flare, worse liver functions and higher model for end-stage liver disease score. Fewer genotype B patients had HBeAg (13% vs. 32%; p = 0.017), but HBV DNA seropositivity (by bDNA assay) was comparable (26% vs. 23%; p = 0.727). The 3-year graft survival was 83% for genotype B and 89% for genotype C (p = 0.2). The rate of HBsAg clearance or seroreversion was the same. The cumulative rate of viral breakthrough due to lamivudine-resistant mutants at 3 years was 4% for genotype B and 21% for genotype C (p = 0.017). Liver biopsy after viral breakthrough showed recurrent hepatitis B in 7 of 10 genotype C patients, including 2 with fibrosing cholestatic hepatitis, and no histologic recurrence in 2 genotype B patients. In conclusion, HBV genotypes B and C are associated with different patterns of end-stage liver diseases that required transplantation, and genotype C may carry a greater risk and severity of recurrence due to lamivudine-resistant mutants. Copyright © Blackwell Munksgaard 2005.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AJTen_HK
dc.relation.ispartofAmerican Journal of Transplantationen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectLamivudineen_HK
dc.subjectMutanten_HK
dc.subjectProphylaxisen_HK
dc.subjectRecurrenceen_HK
dc.subject.meshAdolescent-
dc.subject.meshHepatitis B virus - genetics-
dc.subject.meshHepatitis B, Chronic - surgery-
dc.subject.meshLamivudine - administration and dosage-
dc.subject.meshLiver Transplantation-
dc.titleSignificance of hepatitis B virus genotype in liver transplantation for chronic hepatitis Ben_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1600-6135&volume=5&issue=8&spage=1893&epage=1900&date=2005&atitle=Significance+of+hepatitis+B+virus+genotype+in+liver+transplantation+for+chronic+hepatitis+Ben_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailYuen, MF: mfyuen@hku.hken_HK
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityChan, SC=rp01568en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1600-6143.2005.00952.xen_HK
dc.identifier.pmid15996236-
dc.identifier.scopuseid_2-s2.0-22844437102en_HK
dc.identifier.hkuros120588en_HK
dc.identifier.hkuros122187-
dc.identifier.hkuros138652-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-22844437102&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1893en_HK
dc.identifier.epage1900en_HK
dc.identifier.isiWOS:000230291500015-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridCheung, CK=8714367400en_HK
dc.identifier.scopusauthoridLau, GK=7102301257en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridLiu, CL=7409789712en_HK
dc.identifier.scopusauthoridChan, SC=7404255575en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK
dc.identifier.citeulike245203-

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