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Article: Fasting total plasma homocysteine and atherosclerotic peripheral vascular disease

TitleFasting total plasma homocysteine and atherosclerotic peripheral vascular disease
Authors
Issue Date1997
PublisherElsevier Inc.
Citation
Annals Of Vascular Surgery, 1997, v. 11 n. 3, p. 217-223 How to Cite?
Abstract
Fasting total plasma homocysteine levels were measured by rapid ion- exchange chromatography in 100 patients with symptomatic atherosclerotic peripheral vascular disease (PVD) and 100 age and sex-matched control subjects. Demographic data, biochemistry, hematology, and lipid fractions were measured in both groups, and clinical and vascular laboratory disease parameters were recorded for the patient group. Patients with hyperhomocysteinemia (defined as those with fasting homocysteine values exceeding the 90th percentile of the control range) were compared to patients with normal homocysteine with respect to the above parameters. Total fasting homocysteine concentrations were significantly higher in the patient group (28.8 ± 14.9 μmol/l) than in the control subjects (20.3 ± 11.3 μmol/l; p < 0.001). Homocysteine levels were also higher in males than in females in both the control and the patient groups. Homocysteine correlates positively only with age in the healthy controls (r = 0.291; p < 0.005) but not with other standard risk factors. Multivariate analysis of the biochemical risk factors confirmed that total plasma homocysteine concentration is an independent risk factor for PVD (p < 0.001). Hyperhomocysteinemia is not associated with vitamin B12 or folate deficiency states. Vitamin B12 concentration was 591 ± 313 ng/l in the control group, and 682 ± 405 ng/l in the patient group (p = NS). Serum relate concentration was lower in the controls (7.2 ± 2.3 μg/l) than in the patients (8.3 ± 2.0 μg/I, p < 0.001). Mild hyperhomocysteinemia was detected in 27% of the patients. Patients with hyperhomocysteinemia has a four-fold increase in risk of PVD relative to patients with a normal homocysteine level. There is no significant difference between the two groups with respect to patient demographics, biochemical risk factors, and disease pattern and severity.
Persistent Identifierhttp://hdl.handle.net/10722/83957
ISSN
2013 Impact Factor: 1.029
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorCheng, SWKen_HK
dc.contributor.authorTing, ACWen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:47:13Z-
dc.date.available2010-09-06T08:47:13Z-
dc.date.issued1997en_HK
dc.identifier.citationAnnals Of Vascular Surgery, 1997, v. 11 n. 3, p. 217-223en_HK
dc.identifier.issn0890-5096en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83957-
dc.description.abstractFasting total plasma homocysteine levels were measured by rapid ion- exchange chromatography in 100 patients with symptomatic atherosclerotic peripheral vascular disease (PVD) and 100 age and sex-matched control subjects. Demographic data, biochemistry, hematology, and lipid fractions were measured in both groups, and clinical and vascular laboratory disease parameters were recorded for the patient group. Patients with hyperhomocysteinemia (defined as those with fasting homocysteine values exceeding the 90th percentile of the control range) were compared to patients with normal homocysteine with respect to the above parameters. Total fasting homocysteine concentrations were significantly higher in the patient group (28.8 ± 14.9 μmol/l) than in the control subjects (20.3 ± 11.3 μmol/l; p < 0.001). Homocysteine levels were also higher in males than in females in both the control and the patient groups. Homocysteine correlates positively only with age in the healthy controls (r = 0.291; p < 0.005) but not with other standard risk factors. Multivariate analysis of the biochemical risk factors confirmed that total plasma homocysteine concentration is an independent risk factor for PVD (p < 0.001). Hyperhomocysteinemia is not associated with vitamin B12 or folate deficiency states. Vitamin B12 concentration was 591 ± 313 ng/l in the control group, and 682 ± 405 ng/l in the patient group (p = NS). Serum relate concentration was lower in the controls (7.2 ± 2.3 μg/l) than in the patients (8.3 ± 2.0 μg/I, p < 0.001). Mild hyperhomocysteinemia was detected in 27% of the patients. Patients with hyperhomocysteinemia has a four-fold increase in risk of PVD relative to patients with a normal homocysteine level. There is no significant difference between the two groups with respect to patient demographics, biochemical risk factors, and disease pattern and severity.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc.en_HK
dc.relation.ispartofAnnals of Vascular Surgeryen_HK
dc.rightsAnnals of Vascular Surgery. Copyright © Elsevier Inc.en_HK
dc.titleFasting total plasma homocysteine and atherosclerotic peripheral vascular diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0890-5096&volume=11&spage=217&epage=223&date=1997&atitle=Fasting+total+plasma+homocysteine+and+atherosclerotic+peripheral+vascular+diseaseen_HK
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityCheng, SWK=rp00374en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s100169900037en_HK
dc.identifier.pmid9140594en_HK
dc.identifier.scopuseid_2-s2.0-0030897348en_HK
dc.identifier.hkuros32365en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030897348&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue3en_HK
dc.identifier.spage217en_HK
dc.identifier.epage223en_HK
dc.identifier.isiWOS:A1997WW54300001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, SWK=7404684779en_HK
dc.identifier.scopusauthoridTing, ACW=7102858552en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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