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Article: Role of serum alpha-fetoprotein monitoring in detection of recurrent hepatocellular carcinoma after curative hepatectomy

TitleRole of serum alpha-fetoprotein monitoring in detection of recurrent hepatocellular carcinoma after curative hepatectomy
Authors
KeywordsHepatocellular carcinoma
Recurrence
Serum alpha-fetoprotein
Sensitivity
Specificity
Issue Date2003
PublisherWorld Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/cr/cr.shtml
Citation
Cancer Reviews: Asia-Pacific, 2003, v. 1 n. 2, p. 289-296 How to Cite?
AbstractObjective: To evaluate the usefulness of serum alpha-fetoprotein (AFP) in detecting the recurrence of hepatocellular carcinoma (HCC) after curative hepatectomy. Methods: From January 1995 to February 2000, 283 patients who underwent curative resection of HCC had their post-operative serum AFP levels serially monitored, and the AFP levels at the time of diagnosis of recurrence were analyzed for those patients who developed recurrence. The patients were divided into those with normal (i.e. < 20 ng/ml, n=115) and those with elevated preoperative serum AFP levels (n=168). Results: Of the 283 patients, 151 (53.4%) developed HCC recurrence. In patients with normal preoperative serum AFP levels, the sensitivities of the postoperative serum AFP level in detecting HCC recurrence were 36.7%, 8.3% and 1.7%, respectively, using AFP cut-off levels of 20 ng/ml, 100 ng/ml and 400 ng/ml. The corresponding specificities were 86.3%, 96.1%, and 98.0%, respectively, using the three cut-off levels. In patients who had a raised preoperative serum AFP level ≥ 20 ng/ml, the sensitivities of the AFP tests were 83.1%, 55.1% and 32.6%, respectively, while the specificities were 73.4%, 86.1% and 92.7%, respectively, in detecting recurrence using the three cut-off levels. Conclusions: Serum AFP monitoring, in conjunction with imaging studies, is useful in monitoring recurrent HCC after hepatectomy. For patients with a raised preoperative serum AFP level, a postoperative serum AFP of over 20 ng/ml appears to be the best cut-off level for the detection of HCC recurrence with both satisfactory sensitivity and specificity. For patients with normal preoperative serum AFP levels, the sensitivity of postoperative serum AFP monitoring in the detection of recurrence is low, and hence the role of serum AFP monitoring is limited. Imaging studies are important for this group of patients in surveillance for recurrent HCC. Read More: http://www.worldscientific.com/doi/abs/10.1142/S0219836303000244
Persistent Identifierhttp://hdl.handle.net/10722/83951
ISSN

 

DC FieldValueLanguage
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorSze, PKen_HK
dc.contributor.authorTang, EWHen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:47:09Z-
dc.date.available2010-09-06T08:47:09Z-
dc.date.issued2003en_HK
dc.identifier.citationCancer Reviews: Asia-Pacific, 2003, v. 1 n. 2, p. 289-296en_HK
dc.identifier.issn0219-8363en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83951-
dc.description.abstractObjective: To evaluate the usefulness of serum alpha-fetoprotein (AFP) in detecting the recurrence of hepatocellular carcinoma (HCC) after curative hepatectomy. Methods: From January 1995 to February 2000, 283 patients who underwent curative resection of HCC had their post-operative serum AFP levels serially monitored, and the AFP levels at the time of diagnosis of recurrence were analyzed for those patients who developed recurrence. The patients were divided into those with normal (i.e. < 20 ng/ml, n=115) and those with elevated preoperative serum AFP levels (n=168). Results: Of the 283 patients, 151 (53.4%) developed HCC recurrence. In patients with normal preoperative serum AFP levels, the sensitivities of the postoperative serum AFP level in detecting HCC recurrence were 36.7%, 8.3% and 1.7%, respectively, using AFP cut-off levels of 20 ng/ml, 100 ng/ml and 400 ng/ml. The corresponding specificities were 86.3%, 96.1%, and 98.0%, respectively, using the three cut-off levels. In patients who had a raised preoperative serum AFP level ≥ 20 ng/ml, the sensitivities of the AFP tests were 83.1%, 55.1% and 32.6%, respectively, while the specificities were 73.4%, 86.1% and 92.7%, respectively, in detecting recurrence using the three cut-off levels. Conclusions: Serum AFP monitoring, in conjunction with imaging studies, is useful in monitoring recurrent HCC after hepatectomy. For patients with a raised preoperative serum AFP level, a postoperative serum AFP of over 20 ng/ml appears to be the best cut-off level for the detection of HCC recurrence with both satisfactory sensitivity and specificity. For patients with normal preoperative serum AFP levels, the sensitivity of postoperative serum AFP monitoring in the detection of recurrence is low, and hence the role of serum AFP monitoring is limited. Imaging studies are important for this group of patients in surveillance for recurrent HCC. Read More: http://www.worldscientific.com/doi/abs/10.1142/S0219836303000244-
dc.languageengen_HK
dc.publisherWorld Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/cr/cr.shtmlen_HK
dc.relation.ispartofCancer Reviews: Asia-Pacificen_HK
dc.rightsCancer Reviews: Asia-Pacific. Copyright © World Scientific Publishing Co Pte Ltd.-
dc.subjectHepatocellular carcinoma-
dc.subjectRecurrence-
dc.subjectSerum alpha-fetoprotein-
dc.subjectSensitivity-
dc.subjectSpecificity-
dc.titleRole of serum alpha-fetoprotein monitoring in detection of recurrent hepatocellular carcinoma after curative hepatectomyen_HK
dc.typeArticleen_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.doi10.1142/S0219836303000244-
dc.identifier.hkuros87855en_HK
dc.identifier.volume1-
dc.identifier.issue2-
dc.identifier.spage289-
dc.identifier.epage296-
dc.publisher.placeSingapore-

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