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Article: Association of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograft

TitleAssociation of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograft
Authors
Issue Date2002
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.com
Citation
Transplantation, 2002, v. 74 n. 1, p. 133-138 How to Cite?
AbstractBackground. The CD134/CD134L interaction provides a strong costimulatory signal that is CD28-independent. The CD134/CD134L pathway has been studied in inflammatory, autoimmune diseases, and graft-versus-host disease, but no information exists on the involvement of CD134/CD134L interactions in solid organ transplantation. Methods. CD134/CD134L costimulation was studied in a rat model of small bowel transplantation. Immunohistochemistry and flow cytometry were used to analyze the expression and localization of CD134/ CD134L. Mixed lymphocyte culture and quantitative RT-PCR were used to measure the effect on T proliferation and T helper cell cytokine transcripts of single or combined CD134 and CD28 costimulatory blockade. Results. CD134 and CD134L molecules were strongly expressed in acutely rejected small bowel allografts. This expression was significantly suppressed by FK506. Interruption of the CD134 and CD28 costimulatory pathways resulted in an pronounced increase in expression of interleukin-10 transcripts. Conclusion. These results present the first evidence that the CD134/CD134L interaction is associated with acute allograft rejection. Combined CD134/CD134L blockade may be an effective treatment to both prevent acute allograft rejection and promote the induction of cells with regulatory capacity.
Persistent Identifierhttp://hdl.handle.net/10722/83947
ISSN
2014 Impact Factor: 3.828
2014 SCImago Journal Rankings: 1.453
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTian, Len_HK
dc.contributor.authorGuo, Wen_HK
dc.contributor.authorYuan, Zen_HK
dc.contributor.authorLui, VCHen_HK
dc.contributor.authorChan, JKYen_HK
dc.contributor.authorYagita, Hen_HK
dc.contributor.authorAkiba, Hen_HK
dc.contributor.authorDallman, Men_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T08:47:06Z-
dc.date.available2010-09-06T08:47:06Z-
dc.date.issued2002en_HK
dc.identifier.citationTransplantation, 2002, v. 74 n. 1, p. 133-138en_HK
dc.identifier.issn0041-1337en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83947-
dc.description.abstractBackground. The CD134/CD134L interaction provides a strong costimulatory signal that is CD28-independent. The CD134/CD134L pathway has been studied in inflammatory, autoimmune diseases, and graft-versus-host disease, but no information exists on the involvement of CD134/CD134L interactions in solid organ transplantation. Methods. CD134/CD134L costimulation was studied in a rat model of small bowel transplantation. Immunohistochemistry and flow cytometry were used to analyze the expression and localization of CD134/ CD134L. Mixed lymphocyte culture and quantitative RT-PCR were used to measure the effect on T proliferation and T helper cell cytokine transcripts of single or combined CD134 and CD28 costimulatory blockade. Results. CD134 and CD134L molecules were strongly expressed in acutely rejected small bowel allografts. This expression was significantly suppressed by FK506. Interruption of the CD134 and CD28 costimulatory pathways resulted in an pronounced increase in expression of interleukin-10 transcripts. Conclusion. These results present the first evidence that the CD134/CD134L interaction is associated with acute allograft rejection. Combined CD134/CD134L blockade may be an effective treatment to both prevent acute allograft rejection and promote the induction of cells with regulatory capacity.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.comen_HK
dc.relation.ispartofTransplantationen_HK
dc.rightsTransplantation. Copyright © Lippincott Williams & Wilkins.en_HK
dc.titleAssociation of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograften_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0041-1337&volume=74&issue=1&spage=133&epage=138&date=2002&atitle=Association+of+the+CD134/CD134L+costimulatory+pathway+with+acute+rejection+of+small+bowel+allograften_HK
dc.identifier.emailLui, VCH: vchlui@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityLui, VCH=rp00363en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12134113en_HK
dc.identifier.scopuseid_2-s2.0-0037099452en_HK
dc.identifier.hkuros70996en_HK
dc.identifier.hkuros75799-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037099452&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume74en_HK
dc.identifier.issue1en_HK
dc.identifier.spage133en_HK
dc.identifier.epage138en_HK
dc.identifier.isiWOS:000176998100024-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTian, L=7202296389en_HK
dc.identifier.scopusauthoridGuo, W=35285430300en_HK
dc.identifier.scopusauthoridYuan, Z=10641253300en_HK
dc.identifier.scopusauthoridLui, VCH=7004231344en_HK
dc.identifier.scopusauthoridChan, JKY=15730226000en_HK
dc.identifier.scopusauthoridYagita, H=7202724217en_HK
dc.identifier.scopusauthoridAkiba, H=7005030415en_HK
dc.identifier.scopusauthoridDallman, M=35473592200en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK

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