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Article: An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma

TitleAn integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma
Authors
KeywordsGene expression
HCC
Microarrays
Tumor markers
Issue Date2005
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 2005, v. 24 n. 23, p. 3737-3747 How to Cite?
AbstractHepatocellular carcinoma (HCC) is one of the major causes of cancer deaths worldwide. New diagnostic and therapeutic options are needed for more effective and early detection and treatment of this malignancy. We identified 703 genes that are highly expressed in HCC using DNA microarrays, and further characterized them in order to uncover novel tumor markers, oncogenes, and therapeutic targets for HCC. Using Gene Ontology annotations, genes with functions related to cell proliferation and cell cycle, chromatin, repair, and transcription were found to be significantly enriched in this list of highly expressed genes. We also identified a set of genes that encode secreted (e.g. GPC3, LCN2, and DKK1) or membrane-bound proteins (e.g. GPC3, IGSF1, and PSK-1), which may be attractive candidates for the diagnosis of HCC. A significant enrichment of genes highly expressed in HCC was found on chromosomes 1q, 6p, 8q, and 20q, and we also identified chromosomal clusters of genes highly expressed in HCC. The microarray analyses were validated by RT-PCR and PCR. This approach of integrating other biological information with gene expression in the analysis helps select aberrantly expressed genes in HCC that may be further studied for their diagnostic or therapeutic utility. © 2005 Nature Publishing Group All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/83945
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPatil, MAen_HK
dc.contributor.authorChua, MSen_HK
dc.contributor.authorPan, KHen_HK
dc.contributor.authorLin, Ren_HK
dc.contributor.authorLih, CJen_HK
dc.contributor.authorCheung, STen_HK
dc.contributor.authorHo, Cen_HK
dc.contributor.authorLi, Ren_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorCohen, SNen_HK
dc.contributor.authorChen, Xen_HK
dc.contributor.authorSo, Sen_HK
dc.date.accessioned2010-09-06T08:47:05Z-
dc.date.available2010-09-06T08:47:05Z-
dc.date.issued2005en_HK
dc.identifier.citationOncogene, 2005, v. 24 n. 23, p. 3737-3747en_HK
dc.identifier.issn0950-9232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83945-
dc.description.abstractHepatocellular carcinoma (HCC) is one of the major causes of cancer deaths worldwide. New diagnostic and therapeutic options are needed for more effective and early detection and treatment of this malignancy. We identified 703 genes that are highly expressed in HCC using DNA microarrays, and further characterized them in order to uncover novel tumor markers, oncogenes, and therapeutic targets for HCC. Using Gene Ontology annotations, genes with functions related to cell proliferation and cell cycle, chromatin, repair, and transcription were found to be significantly enriched in this list of highly expressed genes. We also identified a set of genes that encode secreted (e.g. GPC3, LCN2, and DKK1) or membrane-bound proteins (e.g. GPC3, IGSF1, and PSK-1), which may be attractive candidates for the diagnosis of HCC. A significant enrichment of genes highly expressed in HCC was found on chromosomes 1q, 6p, 8q, and 20q, and we also identified chromosomal clusters of genes highly expressed in HCC. The microarray analyses were validated by RT-PCR and PCR. This approach of integrating other biological information with gene expression in the analysis helps select aberrantly expressed genes in HCC that may be further studied for their diagnostic or therapeutic utility. © 2005 Nature Publishing Group All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_HK
dc.relation.ispartofOncogeneen_HK
dc.subjectGene expressionen_HK
dc.subjectHCCen_HK
dc.subjectMicroarraysen_HK
dc.subjectTumor markersen_HK
dc.titleAn integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0950-9232&volume=24&issue=23&spage=3737&epage=3747&date=2005&atitle=An+integrated+data+analysis+approach+to+characterize+genes+highly+expressed+in+hepatocellular+carcinomaen_HK
dc.identifier.emailCheung, ST: stcheung@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityCheung, ST=rp00457en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.onc.1208479en_HK
dc.identifier.scopuseid_2-s2.0-20444475795en_HK
dc.identifier.hkuros99512en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20444475795&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue23en_HK
dc.identifier.spage3737en_HK
dc.identifier.epage3747en_HK
dc.identifier.isiWOS:000229346300005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPatil, MA=8559878100en_HK
dc.identifier.scopusauthoridChua, MS=7006092807en_HK
dc.identifier.scopusauthoridPan, KH=7102713641en_HK
dc.identifier.scopusauthoridLin, R=55213780400en_HK
dc.identifier.scopusauthoridLih, CJ=6602987201en_HK
dc.identifier.scopusauthoridCheung, ST=7202473497en_HK
dc.identifier.scopusauthoridHo, C=8914892800en_HK
dc.identifier.scopusauthoridLi, R=7404723086en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridCohen, SN=35476774500en_HK
dc.identifier.scopusauthoridChen, X=8978110800en_HK
dc.identifier.scopusauthoridSo, S=35238727400en_HK
dc.identifier.citeulike205067-

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