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Article: The impact of postoperative complications on long-term outcomes following curative resection for colorectal cancer

TitleThe impact of postoperative complications on long-term outcomes following curative resection for colorectal cancer
Authors
KeywordsColorectal cancer
Complications
Recurrence
Survival
Issue Date2007
PublisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org
Citation
Annals Of Surgical Oncology, 2007, v. 14 n. 9, p. 2559-2566 How to Cite?
AbstractBackground: This study aimed to investigate the impact of postoperative complications on long-term survival and disease recurrence in patients who underwent curative resection for colorectal cancer. Method: Patients who underwent radical resection for colorectal cancer with curative intent from January 1996 to December 2004 were included. Operative mortality and morbidity were documented prospectively. Factors that might affect long-term outcome were analyzed with multivariate analysis. Results: Curative resection was performed in 1657 patients (943 men), and the median age was 70 years (range: 24-94 years). The 30-day mortality was 2.4%, and the complication rate was 27.3%. Age over 70 years (P < .001, odds ratio: 2.06, 95% CI: 1.63-2.61), male gender (P = .001, odds ratio: 1.49, 95% CI: 1.19-1.88), emergency operation (P < .001, odds ratio: 3.14, 95% CI: 2.26-4.35) and rectal cancer (P < .001, odds ratio: 1.41, 95% CI: 1.25-1.61) were associated with a significantly higher complication rate. With exclusion of patients who died within 30 days, the median follow-up of the surviving patients was 45.3 months. The 5-year overall survival was 64.9%, and the overall recurrence rate was 29.1%. The presence of postoperative complications was an independent factor associated with a worse overall survival (P = .023, hazard ratio: 1.26; 95% CI: 1.03-1.52) and a higher overall recurrence rate (P = .04, hazard ratio: 1.26; 95% CI: 1.01-1.57). Conclusion: The presence of postoperative complication not only affects the short-term results of resection of colorectal cancer, but the long-term oncologic outcomes are also adversely affected. Long-term outcomes can be improved with efforts to reduce postoperative complications. © 2007 Society of Surgical Oncology.
Persistent Identifierhttp://hdl.handle.net/10722/83926
ISSN
2015 Impact Factor: 3.655
2015 SCImago Journal Rankings: 1.902
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLaw, WLen_HK
dc.contributor.authorChoi, HKen_HK
dc.contributor.authorLee, YMen_HK
dc.contributor.authorHo, JWCen_HK
dc.date.accessioned2010-09-06T08:46:51Z-
dc.date.available2010-09-06T08:46:51Z-
dc.date.issued2007en_HK
dc.identifier.citationAnnals Of Surgical Oncology, 2007, v. 14 n. 9, p. 2559-2566en_HK
dc.identifier.issn1068-9265en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83926-
dc.description.abstractBackground: This study aimed to investigate the impact of postoperative complications on long-term survival and disease recurrence in patients who underwent curative resection for colorectal cancer. Method: Patients who underwent radical resection for colorectal cancer with curative intent from January 1996 to December 2004 were included. Operative mortality and morbidity were documented prospectively. Factors that might affect long-term outcome were analyzed with multivariate analysis. Results: Curative resection was performed in 1657 patients (943 men), and the median age was 70 years (range: 24-94 years). The 30-day mortality was 2.4%, and the complication rate was 27.3%. Age over 70 years (P < .001, odds ratio: 2.06, 95% CI: 1.63-2.61), male gender (P = .001, odds ratio: 1.49, 95% CI: 1.19-1.88), emergency operation (P < .001, odds ratio: 3.14, 95% CI: 2.26-4.35) and rectal cancer (P < .001, odds ratio: 1.41, 95% CI: 1.25-1.61) were associated with a significantly higher complication rate. With exclusion of patients who died within 30 days, the median follow-up of the surviving patients was 45.3 months. The 5-year overall survival was 64.9%, and the overall recurrence rate was 29.1%. The presence of postoperative complications was an independent factor associated with a worse overall survival (P = .023, hazard ratio: 1.26; 95% CI: 1.03-1.52) and a higher overall recurrence rate (P = .04, hazard ratio: 1.26; 95% CI: 1.01-1.57). Conclusion: The presence of postoperative complication not only affects the short-term results of resection of colorectal cancer, but the long-term oncologic outcomes are also adversely affected. Long-term outcomes can be improved with efforts to reduce postoperative complications. © 2007 Society of Surgical Oncology.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.orgen_HK
dc.relation.ispartofAnnals of Surgical Oncologyen_HK
dc.subjectColorectal canceren_HK
dc.subjectComplicationsen_HK
dc.subjectRecurrenceen_HK
dc.subjectSurvivalen_HK
dc.titleThe impact of postoperative complications on long-term outcomes following curative resection for colorectal canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1068-9265&volume=14&issue=9&spage=2559&epage=2566&date=2007&atitle=The+impact+of+postoperative+complications+on+long-term+outcomes+following+curative+resection+for+colorectal+canceren_HK
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_HK
dc.identifier.authorityLaw, WL=rp00436en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1245/s10434-007-9434-4en_HK
dc.identifier.pmid17522945-
dc.identifier.scopuseid_2-s2.0-34548557551en_HK
dc.identifier.hkuros141088en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548557551&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue9en_HK
dc.identifier.spage2559en_HK
dc.identifier.epage2566en_HK
dc.identifier.isiWOS:000249400600022-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLaw, WL=7103147867en_HK
dc.identifier.scopusauthoridChoi, HK=7404339913en_HK
dc.identifier.scopusauthoridLee, YM=8521465600en_HK
dc.identifier.scopusauthoridHo, JWC=7402649983en_HK

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