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Article: Glial-derived neurotrophic factor in human adult and fetal intestine and in Hirschsprung's disease

TitleGlial-derived neurotrophic factor in human adult and fetal intestine and in Hirschsprung's disease
Authors
Issue Date1997
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Gastroenterology, 1997, v. 112, p. 1381-1385 How to Cite?
AbstractBackground And Aims: Glial Cell Line-Derived Neurotrophic Factor (Gdnf) Signals Through The Product Of The Ret Proto-Oncogene, Which Is Known To Be Mutated In Hirschsprung's Disease And Other Conditions With Gut Dysmotility. The Aim Of This Study Was To Determine The Presence Of Gdnf And Its Receptor Component (Ret) In Human Adult And Developing Intestine And To Evaluate Their Distribution Pattern In Hirschsprung's Disease. Methods: Gdnf And Ret Were Detected Immunohistochemically, And Gdnf Was Quantified By Immunoassay In Specimens Of Human Adult And Fetal Colon And Hirschsprung's Disease Intestine. Results: Gdnf-Like Immunoreactivity Was Detected In All Specimens. Immunostaining Of Gdnf Was Restricted To Neural Fiberlike Structures Across The Gut Wall And Was Similar To Staining With Markers Of Gila And Schwann Cells. In Contrast, Ret Immunoreactivity Was Found Only In Neural Cell Bodies. Gdnf Levels Determined By Immunoassay Were Higher In Muscle Than Mucosal Gut Layers, And There Was No Difference Between Affected And Unaffected Segments Of Hirschsprung's Disease. Conclusions: Gdnf Is Present In Adult And Fetal Human Gut, Where It May Play A Neurotrophic Role. Its Staining Pattern Suggests That It Is Localized In Gila Or Schwann Cells. There Seems To Be No Difference Of Gdnf Levels Between Affected And Unaffected Intestinal Segments In Hirschsprung's Disease.
Persistent Identifierhttp://hdl.handle.net/10722/83902
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBar, KJen_HK
dc.contributor.authorFacer, Pen_HK
dc.contributor.authorWilliams, NSen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorAnand, Pen_HK
dc.date.accessioned2010-09-06T08:46:34Z-
dc.date.available2010-09-06T08:46:34Z-
dc.date.issued1997en_HK
dc.identifier.citationGastroenterology, 1997, v. 112, p. 1381-1385en_HK
dc.identifier.issn0016-5085en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83902-
dc.description.abstractBackground And Aims: Glial Cell Line-Derived Neurotrophic Factor (Gdnf) Signals Through The Product Of The Ret Proto-Oncogene, Which Is Known To Be Mutated In Hirschsprung's Disease And Other Conditions With Gut Dysmotility. The Aim Of This Study Was To Determine The Presence Of Gdnf And Its Receptor Component (Ret) In Human Adult And Developing Intestine And To Evaluate Their Distribution Pattern In Hirschsprung's Disease. Methods: Gdnf And Ret Were Detected Immunohistochemically, And Gdnf Was Quantified By Immunoassay In Specimens Of Human Adult And Fetal Colon And Hirschsprung's Disease Intestine. Results: Gdnf-Like Immunoreactivity Was Detected In All Specimens. Immunostaining Of Gdnf Was Restricted To Neural Fiberlike Structures Across The Gut Wall And Was Similar To Staining With Markers Of Gila And Schwann Cells. In Contrast, Ret Immunoreactivity Was Found Only In Neural Cell Bodies. Gdnf Levels Determined By Immunoassay Were Higher In Muscle Than Mucosal Gut Layers, And There Was No Difference Between Affected And Unaffected Segments Of Hirschsprung's Disease. Conclusions: Gdnf Is Present In Adult And Fetal Human Gut, Where It May Play A Neurotrophic Role. Its Staining Pattern Suggests That It Is Localized In Gila Or Schwann Cells. There Seems To Be No Difference Of Gdnf Levels Between Affected And Unaffected Intestinal Segments In Hirschsprung's Disease.en_US
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_HK
dc.relation.ispartofGastroenterologyen_HK
dc.titleGlial-derived neurotrophic factor in human adult and fetal intestine and in Hirschsprung's diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-5085&volume=112&spage=1381&epage=1385&date=1997&atitle=Glial-derived+neurotrophic+factor+in+human+adult+and+fetal+intestine+and+in+Hirschsprung%27s+diseaseen_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0016-5085(97)70154-9en_US
dc.identifier.pmid9098026-
dc.identifier.scopuseid_2-s2.0-0030961841en_US
dc.identifier.hkuros33406en_HK
dc.identifier.volume112en_US
dc.identifier.issue4en_US
dc.identifier.spage1381en_US
dc.identifier.epage1385en_US
dc.identifier.isiWOS:A1997WT50400044-

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