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Article: Tolerance of radiofrequency ablation by patients of hepatocellular carcinoma

TitleTolerance of radiofrequency ablation by patients of hepatocellular carcinoma
Authors
KeywordsCirrhosis
Hepatocellular carcinoma
Intolerance
Radiofrequency ablation
Tolerance
Issue Date2009
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00534/index.htm
Citation
Journal Of Hepato-Biliary-Pancreatic Surgery, 2009, v. 16 n. 5, p. 655-660 How to Cite?
AbstractBackground: Radiofrequency ablation (RFA) is currently an effective method for ablation of hepatocellular carcinoma (HCC). Early reports have indicated that RFA is safe and virtually free from major complications. Unlike partial hepatectomy for HCC on patients with cirrhosis, there are no data on the safety limit of RFA. However, information is vital for selection of appropriate patients for the procedure. In this study, we analyzed results from use of RFA on HCC patients and determined the lower limit of liver function with which HCC patients can tolerate RFA. Method: Preoperative variables of 310 patients who underwent RFA for HCC were analyzed to identify the risk factors in RFA intolerance in terms of morbidity associated with stress-induced complications. Results: Thirty-nine (12.6%) patients developed intolerance of RFA. Postoperative morbidity was mainly because of intractable ascites (n = 13), hyperbilirubinemia (n = 10), massive pleural effusion (n = 7), and other complications (n = 14). Multivariate analysis revealed that serum albumin level (P = 0.001), serum bilirubin level (P = 0.000), tumor number (P = 0.002), and RFA duration P = 0.017) all played a role in this issue. Conclusions: Simple data such as serum bilirubin, serum albumin level, and tumor number can be used to predict HCC patients' tolerance of RFA. Avoidance of excessive RFA time and careful monitoring of patients at risk are important means of reducing the postoperative morbidity rate. © Springer 2009.
Persistent Identifierhttp://hdl.handle.net/10722/83890
ISSN
2009 Impact Factor: 1.601
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, TTen_HK
dc.contributor.authorNg, KKen_HK
dc.contributor.authorPoon, RTen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:46:26Z-
dc.date.available2010-09-06T08:46:26Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Hepato-Biliary-Pancreatic Surgery, 2009, v. 16 n. 5, p. 655-660en_HK
dc.identifier.issn0944-1166en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83890-
dc.description.abstractBackground: Radiofrequency ablation (RFA) is currently an effective method for ablation of hepatocellular carcinoma (HCC). Early reports have indicated that RFA is safe and virtually free from major complications. Unlike partial hepatectomy for HCC on patients with cirrhosis, there are no data on the safety limit of RFA. However, information is vital for selection of appropriate patients for the procedure. In this study, we analyzed results from use of RFA on HCC patients and determined the lower limit of liver function with which HCC patients can tolerate RFA. Method: Preoperative variables of 310 patients who underwent RFA for HCC were analyzed to identify the risk factors in RFA intolerance in terms of morbidity associated with stress-induced complications. Results: Thirty-nine (12.6%) patients developed intolerance of RFA. Postoperative morbidity was mainly because of intractable ascites (n = 13), hyperbilirubinemia (n = 10), massive pleural effusion (n = 7), and other complications (n = 14). Multivariate analysis revealed that serum albumin level (P = 0.001), serum bilirubin level (P = 0.000), tumor number (P = 0.002), and RFA duration P = 0.017) all played a role in this issue. Conclusions: Simple data such as serum bilirubin, serum albumin level, and tumor number can be used to predict HCC patients' tolerance of RFA. Avoidance of excessive RFA time and careful monitoring of patients at risk are important means of reducing the postoperative morbidity rate. © Springer 2009.en_HK
dc.languageengen_HK
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00534/index.htmen_HK
dc.relation.ispartofJournal of Hepato-Biliary-Pancreatic Surgeryen_HK
dc.subjectCirrhosisen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectIntoleranceen_HK
dc.subjectRadiofrequency ablationen_HK
dc.subjectToleranceen_HK
dc.titleTolerance of radiofrequency ablation by patients of hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0944-1166&volume=16&issue=5&spage=655&epage=660&date=2009&atitle=Tolerance+of+radiofrequency+ablation+by+patients+of+hepatocellular+carcinomaen_HK
dc.identifier.emailPoon, RT: poontp@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityPoon, RT=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00534-009-0103-9en_HK
dc.identifier.pmid19370304-
dc.identifier.scopuseid_2-s2.0-70049104909en_HK
dc.identifier.hkuros167145en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70049104909&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue5en_HK
dc.identifier.spage655en_HK
dc.identifier.epage660en_HK
dc.identifier.isiWOS:000269533100012-
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridCheung, TT=7103334165en_HK
dc.identifier.scopusauthoridNg, KK=7403179075en_HK
dc.identifier.scopusauthoridPoon, RT=7103097223en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.citeulike4367840-

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