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Article: Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress

TitleInduction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress
Authors
KeywordsGene regulation
Heme oxygenase-1
Ischemic stroke
Oxidative stress
Traditional Chinese medicine
Issue Date2008
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/IJMM/ijmm.htm
Citation
International Journal Of Molecular Medicine, 2008, v. 21 n. 4, p. 405-411 How to Cite?
AbstractTraditional medicines are clinically used to treat post-stroke disorders in China. In search of alternative medicines for post-stroke rehabilitation, we recently identified the heme oxygenase-1 (HO-1) pathway as a key mechanism underlying the biological activities of the ischemic stroke formulation ISF-1. This study was designed to further investigate ISF-1 for HO-1 induction in cultured human cells and corresponding cytoprotective effects against oxidative injury. A rat stroke model induced by middle cerebral artery occlusion was employed to verify the activity of ISF-1 in vivo. It was found that HO-1 expression was induced by ISF-1 in a dose- and time-dependent manner. Four ingredients from ISF-1 were identified to be responsible for HO-1 induction. The appropriate combinations of these active ingredients or purified compounds resulted in synergistic induction of HO-1 expression. A minimal HO-1-inducing formulation was prepared and showed significant cytoprotection against H 2O 2-induced oxidative stress. Collectively, the herbal formulation ISF-1 was capable of inducing HO-1 expression, in vitro and in vivo, offering a potential mechanism for post-stroke rehabilitation. This study may shed light on the development of mechanism-defined therapies based on traditional herbal remedies.
Persistent Identifierhttp://hdl.handle.net/10722/83888
ISSN
2015 Impact Factor: 2.348
2015 SCImago Journal Rankings: 0.868
References

 

DC FieldValueLanguage
dc.contributor.authorRong, Jen_HK
dc.contributor.authorCheung, CYHen_HK
dc.contributor.authorLau, ASYen_HK
dc.contributor.authorShen, Jen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorCheng, YCen_HK
dc.date.accessioned2010-09-06T08:46:25Z-
dc.date.available2010-09-06T08:46:25Z-
dc.date.issued2008en_HK
dc.identifier.citationInternational Journal Of Molecular Medicine, 2008, v. 21 n. 4, p. 405-411en_HK
dc.identifier.issn1107-3756en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83888-
dc.description.abstractTraditional medicines are clinically used to treat post-stroke disorders in China. In search of alternative medicines for post-stroke rehabilitation, we recently identified the heme oxygenase-1 (HO-1) pathway as a key mechanism underlying the biological activities of the ischemic stroke formulation ISF-1. This study was designed to further investigate ISF-1 for HO-1 induction in cultured human cells and corresponding cytoprotective effects against oxidative injury. A rat stroke model induced by middle cerebral artery occlusion was employed to verify the activity of ISF-1 in vivo. It was found that HO-1 expression was induced by ISF-1 in a dose- and time-dependent manner. Four ingredients from ISF-1 were identified to be responsible for HO-1 induction. The appropriate combinations of these active ingredients or purified compounds resulted in synergistic induction of HO-1 expression. A minimal HO-1-inducing formulation was prepared and showed significant cytoprotection against H 2O 2-induced oxidative stress. Collectively, the herbal formulation ISF-1 was capable of inducing HO-1 expression, in vitro and in vivo, offering a potential mechanism for post-stroke rehabilitation. This study may shed light on the development of mechanism-defined therapies based on traditional herbal remedies.en_HK
dc.languageengen_HK
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/IJMM/ijmm.htmen_HK
dc.relation.ispartofInternational Journal of Molecular Medicineen_HK
dc.subjectGene regulationen_HK
dc.subjectHeme oxygenase-1en_HK
dc.subjectIschemic strokeen_HK
dc.subjectOxidative stressen_HK
dc.subjectTraditional Chinese medicineen_HK
dc.titleInduction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stressen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1107-3756&volume=21&issue=4&spage=405&epage=411&date=2008&atitle=Induction+of+heme+oxygenase-1+by+traditional+Chinese+medicine+formulation+ISF-1+and+its+ingredients+as+a+cytoprotective+mechanism+against+oxidative+stressen_HK
dc.identifier.emailRong, J: jrong@hku.hken_HK
dc.identifier.emailLau, ASY: asylau@hku.hken_HK
dc.identifier.emailShen, J: shenjg@hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hku.hken_HK
dc.identifier.authorityRong, J=rp00515en_HK
dc.identifier.authorityLau, ASY=rp00474en_HK
dc.identifier.authorityShen, J=rp00487en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-44649147098en_HK
dc.identifier.hkuros141336en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44649147098&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue4en_HK
dc.identifier.spage405en_HK
dc.identifier.epage411en_HK
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridRong, J=7005980047en_HK
dc.identifier.scopusauthoridCheung, CYH=55437572500en_HK
dc.identifier.scopusauthoridLau, ASY=7202626202en_HK
dc.identifier.scopusauthoridShen, J=7404929947en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK
dc.identifier.scopusauthoridCheng, YC=36041844200en_HK

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