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Article: Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress
Title | Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress |
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Authors | |
Keywords | Gene regulation Heme oxygenase-1 Ischemic stroke Oxidative stress Traditional Chinese medicine |
Issue Date | 2008 |
Publisher | Demetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/IJMM/ijmm.htm |
Citation | International Journal Of Molecular Medicine, 2008, v. 21 n. 4, p. 405-411 How to Cite? |
Abstract | Traditional medicines are clinically used to treat post-stroke disorders in China. In search of alternative medicines for post-stroke rehabilitation, we recently identified the heme oxygenase-1 (HO-1) pathway as a key mechanism underlying the biological activities of the ischemic stroke formulation ISF-1. This study was designed to further investigate ISF-1 for HO-1 induction in cultured human cells and corresponding cytoprotective effects against oxidative injury. A rat stroke model induced by middle cerebral artery occlusion was employed to verify the activity of ISF-1 in vivo. It was found that HO-1 expression was induced by ISF-1 in a dose- and time-dependent manner. Four ingredients from ISF-1 were identified to be responsible for HO-1 induction. The appropriate combinations of these active ingredients or purified compounds resulted in synergistic induction of HO-1 expression. A minimal HO-1-inducing formulation was prepared and showed significant cytoprotection against H 2O 2-induced oxidative stress. Collectively, the herbal formulation ISF-1 was capable of inducing HO-1 expression, in vitro and in vivo, offering a potential mechanism for post-stroke rehabilitation. This study may shed light on the development of mechanism-defined therapies based on traditional herbal remedies. |
Persistent Identifier | http://hdl.handle.net/10722/83888 |
ISSN | 2021 Impact Factor: 5.314 2020 SCImago Journal Rankings: 1.048 |
References |
DC Field | Value | Language |
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dc.contributor.author | Rong, J | en_HK |
dc.contributor.author | Cheung, CYH | en_HK |
dc.contributor.author | Lau, ASY | en_HK |
dc.contributor.author | Shen, J | en_HK |
dc.contributor.author | Tam, PKH | en_HK |
dc.contributor.author | Cheng, YC | en_HK |
dc.date.accessioned | 2010-09-06T08:46:25Z | - |
dc.date.available | 2010-09-06T08:46:25Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | International Journal Of Molecular Medicine, 2008, v. 21 n. 4, p. 405-411 | en_HK |
dc.identifier.issn | 1107-3756 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/83888 | - |
dc.description.abstract | Traditional medicines are clinically used to treat post-stroke disorders in China. In search of alternative medicines for post-stroke rehabilitation, we recently identified the heme oxygenase-1 (HO-1) pathway as a key mechanism underlying the biological activities of the ischemic stroke formulation ISF-1. This study was designed to further investigate ISF-1 for HO-1 induction in cultured human cells and corresponding cytoprotective effects against oxidative injury. A rat stroke model induced by middle cerebral artery occlusion was employed to verify the activity of ISF-1 in vivo. It was found that HO-1 expression was induced by ISF-1 in a dose- and time-dependent manner. Four ingredients from ISF-1 were identified to be responsible for HO-1 induction. The appropriate combinations of these active ingredients or purified compounds resulted in synergistic induction of HO-1 expression. A minimal HO-1-inducing formulation was prepared and showed significant cytoprotection against H 2O 2-induced oxidative stress. Collectively, the herbal formulation ISF-1 was capable of inducing HO-1 expression, in vitro and in vivo, offering a potential mechanism for post-stroke rehabilitation. This study may shed light on the development of mechanism-defined therapies based on traditional herbal remedies. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Demetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/IJMM/ijmm.htm | en_HK |
dc.relation.ispartof | International Journal of Molecular Medicine | en_HK |
dc.subject | Gene regulation | en_HK |
dc.subject | Heme oxygenase-1 | en_HK |
dc.subject | Ischemic stroke | en_HK |
dc.subject | Oxidative stress | en_HK |
dc.subject | Traditional Chinese medicine | en_HK |
dc.title | Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1107-3756&volume=21&issue=4&spage=405&epage=411&date=2008&atitle=Induction+of+heme+oxygenase-1+by+traditional+Chinese+medicine+formulation+ISF-1+and+its+ingredients+as+a+cytoprotective+mechanism+against+oxidative+stress | en_HK |
dc.identifier.email | Rong, J: jrong@hku.hk | en_HK |
dc.identifier.email | Lau, ASY: asylau@hku.hk | en_HK |
dc.identifier.email | Shen, J: shenjg@hku.hk | en_HK |
dc.identifier.email | Tam, PKH: paultam@hku.hk | en_HK |
dc.identifier.authority | Rong, J=rp00515 | en_HK |
dc.identifier.authority | Lau, ASY=rp00474 | en_HK |
dc.identifier.authority | Shen, J=rp00487 | en_HK |
dc.identifier.authority | Tam, PKH=rp00060 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.scopus | eid_2-s2.0-44649147098 | en_HK |
dc.identifier.hkuros | 141336 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-44649147098&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 21 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 405 | en_HK |
dc.identifier.epage | 411 | en_HK |
dc.publisher.place | Greece | en_HK |
dc.identifier.scopusauthorid | Rong, J=7005980047 | en_HK |
dc.identifier.scopusauthorid | Cheung, CYH=55437572500 | en_HK |
dc.identifier.scopusauthorid | Lau, ASY=7202626202 | en_HK |
dc.identifier.scopusauthorid | Shen, J=7404929947 | en_HK |
dc.identifier.scopusauthorid | Tam, PKH=7202539421 | en_HK |
dc.identifier.scopusauthorid | Cheng, YC=36041844200 | en_HK |
dc.identifier.issnl | 1107-3756 | - |