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Article: The role of whole-body positron emission tomography with [18F]fluorodeoxyglucose in identifying operable colorectal cancer metastases to the liver

TitleThe role of whole-body positron emission tomography with [18F]fluorodeoxyglucose in identifying operable colorectal cancer metastases to the liver
Authors
Issue Date1996
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archsurg.com
Citation
Archives Of Surgery, 1996, v. 131 n. 7, p. 703-707 How to Cite?
AbstractObjective: To compare the accuracy of whole-body positron emission tomography (PET)using [18F]fluorodeoxyglucose (FDG) with conventional radiological imaging techniques in identifying operable colorectal cancer metastases to the liver. Design: A double-blind comparative study of FDG-PET as the criterion standard vs conventional radiological imaging methods as the criterion standard, in staging of recurrent colorectal cancer. Setting: Institutional practice in a tertiary referral center. Patients: Thirty-four consecutive patients with suspected colorectal cancer metastases, recruited for the study between May 1993 and October 1994. Interventions: Conventional radiological methods of cancer staging included abdominal computed tomography (CT) (n=34), chest x-rays (n=15), and chest CT (n=19) to evaluate extrahepatic disease. Twenty-seven patients were subsequently considered to have apparently isolated cancer metastases to the liver. Anatomical resectability was assessed by magnetic resonance imaging (n=24) or CT angiography (n=3) in all study patients. The FDG-PET studies (n=34) were performed within 8 weeks of conventional radiological imaging. Main Outcome Measures: Malignancy of suspected lesions detected by means of FDG-PET and conventional radiological imaging was confirmed by histopathologic examination of resected specimens and percutaneous biopsy specimens and by serial CT scans demonstrating progression of disease. Results: Unsuspected extrahepatic malignant disease that was missed by conventional radiological imaging was detected by FDG-PET in 11 patients (32%). The PET-detected extrahepatic malignant disease included retroperitoneal nodal metastases (n=6), pulmonary metastases (n=3), and locoregional cancer recurrences (n=2). The additional information afforded by PET consequently had an influence on the clinical management in 10 patients (29%). Conclusion: The FDG-PET method enabled selection of patients with apparently curable colorectal cancer metastases to the liver for hepatic resection.
Persistent Identifierhttp://hdl.handle.net/10722/83878
ISSN
2014 Impact Factor: 4.926
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, DTMen_HK
dc.contributor.authorFulham, Men_HK
dc.contributor.authorStephen, MSen_HK
dc.contributor.authorChu, KMen_HK
dc.contributor.authorSolomon, Men_HK
dc.contributor.authorThompson, JFen_HK
dc.contributor.authorSheldon, DMen_HK
dc.contributor.authorStorey, DWen_HK
dc.date.accessioned2010-09-06T08:46:18Z-
dc.date.available2010-09-06T08:46:18Z-
dc.date.issued1996en_HK
dc.identifier.citationArchives Of Surgery, 1996, v. 131 n. 7, p. 703-707en_HK
dc.identifier.issn0004-0010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83878-
dc.description.abstractObjective: To compare the accuracy of whole-body positron emission tomography (PET)using [18F]fluorodeoxyglucose (FDG) with conventional radiological imaging techniques in identifying operable colorectal cancer metastases to the liver. Design: A double-blind comparative study of FDG-PET as the criterion standard vs conventional radiological imaging methods as the criterion standard, in staging of recurrent colorectal cancer. Setting: Institutional practice in a tertiary referral center. Patients: Thirty-four consecutive patients with suspected colorectal cancer metastases, recruited for the study between May 1993 and October 1994. Interventions: Conventional radiological methods of cancer staging included abdominal computed tomography (CT) (n=34), chest x-rays (n=15), and chest CT (n=19) to evaluate extrahepatic disease. Twenty-seven patients were subsequently considered to have apparently isolated cancer metastases to the liver. Anatomical resectability was assessed by magnetic resonance imaging (n=24) or CT angiography (n=3) in all study patients. The FDG-PET studies (n=34) were performed within 8 weeks of conventional radiological imaging. Main Outcome Measures: Malignancy of suspected lesions detected by means of FDG-PET and conventional radiological imaging was confirmed by histopathologic examination of resected specimens and percutaneous biopsy specimens and by serial CT scans demonstrating progression of disease. Results: Unsuspected extrahepatic malignant disease that was missed by conventional radiological imaging was detected by FDG-PET in 11 patients (32%). The PET-detected extrahepatic malignant disease included retroperitoneal nodal metastases (n=6), pulmonary metastases (n=3), and locoregional cancer recurrences (n=2). The additional information afforded by PET consequently had an influence on the clinical management in 10 patients (29%). Conclusion: The FDG-PET method enabled selection of patients with apparently curable colorectal cancer metastases to the liver for hepatic resection.en_HK
dc.languageengen_HK
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archsurg.comen_HK
dc.relation.ispartofArchives of Surgeryen_HK
dc.titleThe role of whole-body positron emission tomography with [18F]fluorodeoxyglucose in identifying operable colorectal cancer metastases to the liveren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0004-0010&volume=131&spage=703&epage=707&date=1996&atitle=The+role+of+whole-body+positron+emission+tomography+with+18F-Fluorodeoxyglucose+in+identifying+operable+colorectal+cancer+metastases+to+the+liveren_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8678767-
dc.identifier.scopuseid_2-s2.0-0029900872en_HK
dc.identifier.hkuros22232en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029900872&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume131en_HK
dc.identifier.issue7en_HK
dc.identifier.spage703en_HK
dc.identifier.epage707en_HK
dc.identifier.isiWOS:A1996UW18300006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLai, DTM=25938381300en_HK
dc.identifier.scopusauthoridFulham, M=7005082387en_HK
dc.identifier.scopusauthoridStephen, MS=7005060516en_HK
dc.identifier.scopusauthoridChu, KM=7402453538en_HK
dc.identifier.scopusauthoridSolomon, M=7202021741en_HK
dc.identifier.scopusauthoridThompson, JF=7405820652en_HK
dc.identifier.scopusauthoridSheldon, DM=7004835123en_HK
dc.identifier.scopusauthoridStorey, DW=7102776637en_HK

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