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Article: Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes

TitleSonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes
Authors
Issue Date2006
PublisherOxford University Press. The Journal's web site is located at http://intimm.oxfordjournals.org/
Citation
International Immunology, 2006, v. 18 n. 12, p. 1627-1636 How to Cite?
AbstractSonic hedgehog (Shh) is a crucial morphogen in the development of numerous tissues and organs, including the nervous system, gastrointestinal tract and lung. Recent findings suggest that Shh plays an important role in thymocyte development and peripheral T cell function. Here we report that the Shh receptors, patched and smoothened, are expressed in resting and activated T cells and their expression is regulated upon T cell activation. Shh protein is also detected on the surface of freshly isolated T cells. Although exogenous Shh alone does not activate resting T cells, it exhibits co-stimulatory activity which is reflected in its ability to potentiate CD3-mediated proliferation and cytokine production by CD4+ T cells. The co-stimulatory effect is most prominent at sub-optimal TCR stimulation level. Gene expression analysis reveals that Shh signaling in CD4+ T cells modulates a different set of transcriptional targets from that in neuronal cells. Furthermore, Shh co-stimulation modulates the expression of a subset of CD28-responsive genes, including cyclin A and B cell translocation gene 2. © 2006 Oxford University Press.
Persistent Identifierhttp://hdl.handle.net/10722/83871
ISSN
2014 Impact Factor: 2.536
2014 SCImago Journal Rankings: 1.488
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, VSFen_HK
dc.contributor.authorChau, SYen_HK
dc.contributor.authorTian, Len_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorKwong, SKYen_HK
dc.contributor.authorQuackenbush, Jen_HK
dc.contributor.authorDallman, Men_HK
dc.contributor.authorLamb, Jen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T08:46:13Z-
dc.date.available2010-09-06T08:46:13Z-
dc.date.issued2006en_HK
dc.identifier.citationInternational Immunology, 2006, v. 18 n. 12, p. 1627-1636en_HK
dc.identifier.issn0953-8178en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83871-
dc.description.abstractSonic hedgehog (Shh) is a crucial morphogen in the development of numerous tissues and organs, including the nervous system, gastrointestinal tract and lung. Recent findings suggest that Shh plays an important role in thymocyte development and peripheral T cell function. Here we report that the Shh receptors, patched and smoothened, are expressed in resting and activated T cells and their expression is regulated upon T cell activation. Shh protein is also detected on the surface of freshly isolated T cells. Although exogenous Shh alone does not activate resting T cells, it exhibits co-stimulatory activity which is reflected in its ability to potentiate CD3-mediated proliferation and cytokine production by CD4+ T cells. The co-stimulatory effect is most prominent at sub-optimal TCR stimulation level. Gene expression analysis reveals that Shh signaling in CD4+ T cells modulates a different set of transcriptional targets from that in neuronal cells. Furthermore, Shh co-stimulation modulates the expression of a subset of CD28-responsive genes, including cyclin A and B cell translocation gene 2. © 2006 Oxford University Press.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://intimm.oxfordjournals.org/en_HK
dc.relation.ispartofInternational Immunologyen_HK
dc.subject.meshAntigens, CD28 - metabolism-
dc.subject.meshCD4-Positive T-Lymphocytes - immunology-
dc.subject.meshGene Expression Regulation-
dc.subject.meshHedgehog Proteins - metabolism - physiology-
dc.subject.meshLymphocyte Activation-
dc.titleSonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0953-8178&volume=18&issue=12&spage=1627&epage=1636&date=2006&atitle=Sonic+hedgehog+promotes+CD4++T+lymphocyte+proliferation+and+modulates+the+expression+of+a+subset+of+CD28-targeted+genesen_HK
dc.identifier.emailChan, VSF:sfvchan@hku.hken_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hken_HK
dc.identifier.authorityChan, VSF=rp01459en_HK
dc.identifier.authorityChen, Y=rp01318en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/intimm/dxl096en_HK
dc.identifier.pmid17005629-
dc.identifier.scopuseid_2-s2.0-33845360508en_HK
dc.identifier.hkuros137862en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845360508&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1627en_HK
dc.identifier.epage1636en_HK
dc.identifier.isiWOS:000242716500001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, VSF=35200370000en_HK
dc.identifier.scopusauthoridChau, SY=15129057800en_HK
dc.identifier.scopusauthoridTian, L=7202296389en_HK
dc.identifier.scopusauthoridChen, Y=36463185300en_HK
dc.identifier.scopusauthoridKwong, SKY=15128878500en_HK
dc.identifier.scopusauthoridQuackenbush, J=7004974520en_HK
dc.identifier.scopusauthoridDallman, M=35473592200en_HK
dc.identifier.scopusauthoridLamb, J=7201524642en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK
dc.identifier.citeulike970030-

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