Article: Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleSonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes
AuthorsChan, VSF3
Chau, SY3
Tian, L2 3
Chen, Y3
Kwong, SKY1
Quackenbush, J1
Dallman, M5
Lamb, J4
Tam, PKH3
Issue Date2006
PublisherOxford University Press. The Journal's web site is located at http://intimm.oxfordjournals.org/
CitationInternational Immunology, 2006, v. 18 n. 12, p. 1627-1636 [How to Cite?]
DOI: http://dx.doi.org/10.1093/intimm/dxl096
AbstractSonic hedgehog (Shh) is a crucial morphogen in the development of numerous tissues and organs, including the nervous system, gastrointestinal tract and lung. Recent findings suggest that Shh plays an important role in thymocyte development and peripheral T cell function. Here we report that the Shh receptors, patched and smoothened, are expressed in resting and activated T cells and their expression is regulated upon T cell activation. Shh protein is also detected on the surface of freshly isolated T cells. Although exogenous Shh alone does not activate resting T cells, it exhibits co-stimulatory activity which is reflected in its ability to potentiate CD3-mediated proliferation and cytokine production by CD4+ T cells. The co-stimulatory effect is most prominent at sub-optimal TCR stimulation level. Gene expression analysis reveals that Shh signaling in CD4+ T cells modulates a different set of transcriptional targets from that in neuronal cells. Furthermore, Shh co-stimulation modulates the expression of a subset of CD28-responsive genes, including cyclin A and B cell translocation gene 2. © 2006 Oxford University Press.
ISSN0953-8178
2011 Impact Factor: 3.415
2011 SCImago Journal Rankings: 0.722
DOIhttp://dx.doi.org/10.1093/intimm/dxl096
ISI Accession Number IDWOS:000242716500001
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChan, VSF
dc.contributor.authorChau, SY
dc.contributor.authorTian, L
dc.contributor.authorChen, Y
dc.contributor.authorKwong, SKY
dc.contributor.authorQuackenbush, J
dc.contributor.authorDallman, M
dc.contributor.authorLamb, J
dc.contributor.authorTam, PKH
dc.date.accessioned2010-09-06T08:46:13Z
dc.date.available2010-09-06T08:46:13Z
dc.date.issued2006
dc.description.abstractSonic hedgehog (Shh) is a crucial morphogen in the development of numerous tissues and organs, including the nervous system, gastrointestinal tract and lung. Recent findings suggest that Shh plays an important role in thymocyte development and peripheral T cell function. Here we report that the Shh receptors, patched and smoothened, are expressed in resting and activated T cells and their expression is regulated upon T cell activation. Shh protein is also detected on the surface of freshly isolated T cells. Although exogenous Shh alone does not activate resting T cells, it exhibits co-stimulatory activity which is reflected in its ability to potentiate CD3-mediated proliferation and cytokine production by CD4+ T cells. The co-stimulatory effect is most prominent at sub-optimal TCR stimulation level. Gene expression analysis reveals that Shh signaling in CD4+ T cells modulates a different set of transcriptional targets from that in neuronal cells. Furthermore, Shh co-stimulation modulates the expression of a subset of CD28-responsive genes, including cyclin A and B cell translocation gene 2. © 2006 Oxford University Press.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationInternational Immunology, 2006, v. 18 n. 12, p. 1627-1636 [How to Cite?]
DOI: http://dx.doi.org/10.1093/intimm/dxl096
dc.identifier.citeulike970030
dc.identifier.doihttp://dx.doi.org/10.1093/intimm/dxl096
dc.identifier.epage1636
dc.identifier.hkuros137862
dc.identifier.isiWOS:000242716500001
dc.identifier.issn0953-8178
2011 Impact Factor: 3.415
2011 SCImago Journal Rankings: 0.722
dc.identifier.issue12
dc.identifier.openurl
dc.identifier.pmid17005629
dc.identifier.scopuseid_2-s2.0-33845360508
dc.identifier.spage1627
dc.identifier.urihttp://hdl.handle.net/10722/83871
dc.identifier.volume18
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://intimm.oxfordjournals.org/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofInternational Immunology
dc.relation.referencesReferences in Scopus
dc.subject.meshAntigens, CD28 - metabolism
dc.subject.meshCD4-Positive T-Lymphocytes - immunology
dc.subject.meshGene Expression Regulation
dc.subject.meshHedgehog Proteins - metabolism - physiology
dc.subject.meshLymphocyte Activation
dc.titleSonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes
dc.typeArticle
Author Affiliations
  1. Institute for Genome Research
  2. University of Sydney
  3. The University of Hong Kong
  4. GlaxoSmithKline
  5. Imperial College London