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Article: High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma

TitleHigh prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma
Authors
Issue Date2005
PublisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/
Citation
European Journal Of Endocrinology, 2005, v. 152 n. 4, p. 545-550 How to Cite?
AbstractBackground: Cyclooxygenase-2 (COX-2) seems to play a role in the development and carcinogenesis of papillary thyroid carcinoma. Its incidence of expression and potential application as a tumor marker remain to be elucidated. Materials and methods: Immunohistochemical staining for COX-2 expression was performed for 30 papillary thyroid carcinoma (PTC) and 40 benign thyroid specimens. COX-2 mRNA expression was analyzed using a reverse transcriptase-polymerase chain reaction (RT-PCR) for paired fresh frozen tissues removed from surgically resected PTC specimens. Results: COX-2 expression was detected by immunohistochemistry in 27 of 30 (90%) PTC but was absent in 40 benign thyroid specimens, including 27 nodular hyperplasia, 7 follicular adenoma and 6 lymphocytic thyroiditis. Two of the three COX-2 negative carcinomas were follicular variant of PTC. RT-PCR analysis confirmed COX-2 mRNA over-expression in 14 of 20 (70%) paired specimens of PTC. Real-time quantitative RT-PCR showed that the level of COX-2 mRNA expression was significantly higher in PTC than in both the adjacent non-cancerous tissues and the benign thyroid specimens. Conclusion: COX-2 is frequently expressed in PTC but not in benign thyroid specimens. COX-2 expression may serve as a useful molecular marker for PTC in cases of diagnostic difficulty. © 2005 Society of the European Journal of Endocrinology.
Persistent Identifierhttp://hdl.handle.net/10722/83866
ISSN
2015 Impact Factor: 3.892
2015 SCImago Journal Rankings: 1.579
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLo, CYen_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorLeung, PPen_HK
dc.contributor.authorLuk, JMen_HK
dc.date.accessioned2010-09-06T08:46:09Z-
dc.date.available2010-09-06T08:46:09Z-
dc.date.issued2005en_HK
dc.identifier.citationEuropean Journal Of Endocrinology, 2005, v. 152 n. 4, p. 545-550en_HK
dc.identifier.issn0804-4643en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83866-
dc.description.abstractBackground: Cyclooxygenase-2 (COX-2) seems to play a role in the development and carcinogenesis of papillary thyroid carcinoma. Its incidence of expression and potential application as a tumor marker remain to be elucidated. Materials and methods: Immunohistochemical staining for COX-2 expression was performed for 30 papillary thyroid carcinoma (PTC) and 40 benign thyroid specimens. COX-2 mRNA expression was analyzed using a reverse transcriptase-polymerase chain reaction (RT-PCR) for paired fresh frozen tissues removed from surgically resected PTC specimens. Results: COX-2 expression was detected by immunohistochemistry in 27 of 30 (90%) PTC but was absent in 40 benign thyroid specimens, including 27 nodular hyperplasia, 7 follicular adenoma and 6 lymphocytic thyroiditis. Two of the three COX-2 negative carcinomas were follicular variant of PTC. RT-PCR analysis confirmed COX-2 mRNA over-expression in 14 of 20 (70%) paired specimens of PTC. Real-time quantitative RT-PCR showed that the level of COX-2 mRNA expression was significantly higher in PTC than in both the adjacent non-cancerous tissues and the benign thyroid specimens. Conclusion: COX-2 is frequently expressed in PTC but not in benign thyroid specimens. COX-2 expression may serve as a useful molecular marker for PTC in cases of diagnostic difficulty. © 2005 Society of the European Journal of Endocrinology.en_HK
dc.languageengen_HK
dc.publisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/en_HK
dc.relation.ispartofEuropean Journal of Endocrinologyen_HK
dc.titleHigh prevalence of cyclooxygenase 2 expression in papillary thyroid carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0804-4643&volume=152&issue=4&spage=545&epage=550&date=2005&atitle=High+prevalence+of+cyclooxygenase+2+expression+in+papillary+thyroid+carcinomaen_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1530/eje.1.01883en_HK
dc.identifier.pmid15817909-
dc.identifier.scopuseid_2-s2.0-17744362089en_HK
dc.identifier.hkuros97894en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17744362089&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume152en_HK
dc.identifier.issue4en_HK
dc.identifier.spage545en_HK
dc.identifier.epage550en_HK
dc.identifier.isiWOS:000228639700007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLo, CY=16417392800en_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridLeung, PP=7401749062en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK

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