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Article: Bilirubin derived from heme degradation suppresses MHC class II expression in endothelial cells

TitleBilirubin derived from heme degradation suppresses MHC class II expression in endothelial cells
Authors
KeywordsBilirubin
Endothelial cells
Heme oxygenase-1
Interferon-γ
Major histocompatibility complex class II
Issue Date2005
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2005, v. 338 n. 2, p. 890-896 How to Cite?
AbstractThe enzymatic action of heme oxygenase (HO) is mediated by the cleavage of heme into carbon monoxide, ferrous iron, and biliverdin/bilirubin. Here, we show that induction of HO-1 expression, an inducible form of HO, down-regulates IFN-γ-induced MHC class II expression in endothelial cells. Among three catalytic products of HO, bilirubin, but not carbon monoxide or ferrous iron, mediated the suppressive effects of HO through the reduction of mRNA levels of Stat-1-dependent class II transactivator. Expression of HO-1 could suppress the levels of IFN-γ-induced Stat-1 phosphorylation. This effect could be mimicked by exposing the cells to one of its catalytic products, bilirubin. In addition, HO-1 or bilirubin could modulate the transcript activities of Stat-1-driven gene expression in luciferase reporter assays. These findings suggest an important role of HO-1 in the modulation of immune responses through suppression of MHC-II expression in antigen presenting cells. Our data provide a new line of evidence supporting HO-1-targeted therapy for immune modulation. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/83865
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, Jen_HK
dc.contributor.authorMa, Jen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorSchlitt, HJen_HK
dc.contributor.authorTsui, TYen_HK
dc.date.accessioned2010-09-06T08:46:08Z-
dc.date.available2010-09-06T08:46:08Z-
dc.date.issued2005en_HK
dc.identifier.citationBiochemical And Biophysical Research Communications, 2005, v. 338 n. 2, p. 890-896en_HK
dc.identifier.issn0006-291Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/83865-
dc.description.abstractThe enzymatic action of heme oxygenase (HO) is mediated by the cleavage of heme into carbon monoxide, ferrous iron, and biliverdin/bilirubin. Here, we show that induction of HO-1 expression, an inducible form of HO, down-regulates IFN-γ-induced MHC class II expression in endothelial cells. Among three catalytic products of HO, bilirubin, but not carbon monoxide or ferrous iron, mediated the suppressive effects of HO through the reduction of mRNA levels of Stat-1-dependent class II transactivator. Expression of HO-1 could suppress the levels of IFN-γ-induced Stat-1 phosphorylation. This effect could be mimicked by exposing the cells to one of its catalytic products, bilirubin. In addition, HO-1 or bilirubin could modulate the transcript activities of Stat-1-driven gene expression in luciferase reporter assays. These findings suggest an important role of HO-1 in the modulation of immune responses through suppression of MHC-II expression in antigen presenting cells. Our data provide a new line of evidence supporting HO-1-targeted therapy for immune modulation. © 2005 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_HK
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_HK
dc.subjectBilirubinen_HK
dc.subjectEndothelial cellsen_HK
dc.subjectHeme oxygenase-1en_HK
dc.subjectInterferon-γen_HK
dc.subjectMajor histocompatibility complex class IIen_HK
dc.titleBilirubin derived from heme degradation suppresses MHC class II expression in endothelial cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-291X&volume=338&issue=2&spage=890&epage=896&date=2005&atitle=Bilirubin+derived+from+heme+degradation+suppresses+MHC+class+II+expression+in+endothelial+cellsen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbrc.2005.10.021en_HK
dc.identifier.pmid16246303-
dc.identifier.scopuseid_2-s2.0-27744523788en_HK
dc.identifier.hkuros116943en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27744523788&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume338en_HK
dc.identifier.issue2en_HK
dc.identifier.spage890en_HK
dc.identifier.epage896en_HK
dc.identifier.isiWOS:000233451100029-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, J=8901221000en_HK
dc.identifier.scopusauthoridMa, J=7406201578en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridSchlitt, HJ=7005572464en_HK
dc.identifier.scopusauthoridTsui, TY=7006622455en_HK

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