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Article: Can local secretion of prostaglandin E2, Thromboxane B 2, and interleukin-6 play a role in ruptured abdominal aortic aneurysm?

TitleCan local secretion of prostaglandin E2, Thromboxane B 2, and interleukin-6 play a role in ruptured abdominal aortic aneurysm?
Authors
Issue Date2008
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/
Citation
World Journal Of Surgery, 2008, v. 32 n. 1, p. 55-61 How to Cite?
AbstractBackground: Our laboratory has previously shown that the levels of secreted prostaglandin E2 (PGE2), Thromboxane B2 (TxB2), and interleukin-6 (IL-6) by aortic explant cultures were high in patients with ruptured abdominal aortic aneurysm (AAA). In the present study, we sought to examine the secretory levels of these inflammatory mediators in aortic explant cultured from a group of AAAs rupturing at a certain size and a group that did not rupture at that size. It was thought that such a comparison might reveal the contribution of those inflammatory mediators to the risk of AAA rupture. Materials and methods: All subjects had abdominal computed tomography (CT) scans to determine the size of the aneurysm, and surgical aortic tissue was collected from both nonruptured AAAs (18 with a mean size of 6 + 0.5 cm [range: 5-7 cm] and 12 with a mean size of 8 + 0.1 cm [range: 7.01-10 cm]) and ruptured AAAs (10 with a mean size of 5.8 + 0.3 cm [range: 5-7 cm] and 10 with a mean size of 7.8 + 0.1 cm [range: 7.01-10 cm]). Aortic explant cultures from different sizes of aneurysms were immediately established and the culture media were collected 72 h later. Results: The levels of PGE2, TxB2, and IL-6 secreted in the cultured medium were quantified by specific enzyme-linked immunosorbent assays (ELISA). The secretary levels of PGE2, TxB2, and IL-6 were significantly higher in ruptured AAAs than in nonruptured AAAs of similar diameter. However, there was no correlation between these three inflammatory mediators and the size of AAA. Conclusions: This study shows that these inflammatory mediators may play a role in the progression toward rupture but may not be responsible for the expansion of AAA. © 2007 Société Internationale de Chirurgie.
Persistent Identifierhttp://hdl.handle.net/10722/83857
ISSN
2015 Impact Factor: 2.523
2015 SCImago Journal Rankings: 1.375
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheuk, BLYen_HK
dc.contributor.authorCheng, SWKen_HK
dc.date.accessioned2010-09-06T08:46:03Z-
dc.date.available2010-09-06T08:46:03Z-
dc.date.issued2008en_HK
dc.identifier.citationWorld Journal Of Surgery, 2008, v. 32 n. 1, p. 55-61en_HK
dc.identifier.issn0364-2313en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83857-
dc.description.abstractBackground: Our laboratory has previously shown that the levels of secreted prostaglandin E2 (PGE2), Thromboxane B2 (TxB2), and interleukin-6 (IL-6) by aortic explant cultures were high in patients with ruptured abdominal aortic aneurysm (AAA). In the present study, we sought to examine the secretory levels of these inflammatory mediators in aortic explant cultured from a group of AAAs rupturing at a certain size and a group that did not rupture at that size. It was thought that such a comparison might reveal the contribution of those inflammatory mediators to the risk of AAA rupture. Materials and methods: All subjects had abdominal computed tomography (CT) scans to determine the size of the aneurysm, and surgical aortic tissue was collected from both nonruptured AAAs (18 with a mean size of 6 + 0.5 cm [range: 5-7 cm] and 12 with a mean size of 8 + 0.1 cm [range: 7.01-10 cm]) and ruptured AAAs (10 with a mean size of 5.8 + 0.3 cm [range: 5-7 cm] and 10 with a mean size of 7.8 + 0.1 cm [range: 7.01-10 cm]). Aortic explant cultures from different sizes of aneurysms were immediately established and the culture media were collected 72 h later. Results: The levels of PGE2, TxB2, and IL-6 secreted in the cultured medium were quantified by specific enzyme-linked immunosorbent assays (ELISA). The secretary levels of PGE2, TxB2, and IL-6 were significantly higher in ruptured AAAs than in nonruptured AAAs of similar diameter. However, there was no correlation between these three inflammatory mediators and the size of AAA. Conclusions: This study shows that these inflammatory mediators may play a role in the progression toward rupture but may not be responsible for the expansion of AAA. © 2007 Société Internationale de Chirurgie.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/en_HK
dc.relation.ispartofWorld Journal of Surgeryen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshAortic Aneurysm, Abdominal - metabolism - radiography - surgery-
dc.subject.meshAortic Rupture - metabolism - radiography - surgery-
dc.subject.meshDinoprostone - secretion-
dc.subject.meshInterleukin-6 - secretion-
dc.subject.meshThromboxane B2 - secretion-
dc.titleCan local secretion of prostaglandin E2, Thromboxane B 2, and interleukin-6 play a role in ruptured abdominal aortic aneurysm?en_HK
dc.typeArticleen_HK
dc.identifier.emailCheuk, BLY: bernice@hku.hken_HK
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hken_HK
dc.identifier.authorityCheuk, BLY=rp01671en_HK
dc.identifier.authorityCheng, SWK=rp00374en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00268-007-9279-9en_HK
dc.identifier.pmid17992560-
dc.identifier.scopuseid_2-s2.0-37449027203en_HK
dc.identifier.hkuros139620en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37449027203&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue1en_HK
dc.identifier.spage55en_HK
dc.identifier.epage61en_HK
dc.identifier.isiWOS:000251797400011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheuk, BLY=7801343617en_HK
dc.identifier.scopusauthoridCheng, SWK=7404684779en_HK

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