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Conference Paper: Donor quality of life before and after adult-to-adult live donor liver transplantation

TitleDonor quality of life before and after adult-to-adult live donor liver transplantation
Authors
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
The 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004. How to Cite?
AbstractBackground Donor right hepatectomy subjects a healthy donor to an ultra-major surgical operation only for the benefit of the recipient. This has become a standard treatment modality to partially relieve the refractory shortage of cadaveric liver grafts. Justification of this procedure ought to be made with the full knowledge of the potential negative effects on the donor. Psychosocial assessment and monitoring of the donor has to be an integral part of such program. Aim of study To quantify the impact of donor right hepatectomy including the middle hepatic vein on donor quality of life before and after surgery longitudinally. Materials and methods Questionnaires with condition specific and generic components were completed by a face-to-face interview by one of the two full-time liver transplantation coordinators before operation, and 1, 2, 3, 6, and 12 months after operation. The generic instruments used were Karnofsky Performance Status, and the Chinese (Hong Kong) version of the Medical Outcomes Study 36-Item Short-form Survey. The latter measures eight concepts: physical functioning, physical role, emotional role, social functioning, bodily pain, mental health, vitality, and general health. Condition specific questions were also included. Results Between November 2002 and November 2003, 30 consecutive donors who underwent donor right hepatectomy including the middle hepatic vein were assessed and monitored prospectively before and after surgery. They were aged 35 years (21 to 56), with male to female ratio of 33.3%:66.7%. The median follow-up was 6 months (2 to 12). All except 1 were Chinese (1 Indian). There was no donor mortality or major complications. All the donors completed the questionnaires on schedule. Donor quality of life before surgery was excellent physically as they were by definition healthy individuals. The worsening was most significant in the 1st to 3rd month post-operatively, especially in the domains of physical functioning and bodily pain. These and other psychological aspects returned to the previous levels in 6 months’ time. 86.7% (N=26) of these donors reckoned that their donor experience was positive. Conclusion Donor quality of life was adversely affected immediately following surgery. Return to previous levels could be expected at 6 month in large majority of donors. Live donor liver transplantation seems to be acceptable for the rescue of recipients with end-stage liver disease as adverse changes in donor quality of health is temporary.
Persistent Identifierhttp://hdl.handle.net/10722/83838
ISSN
2015 Impact Factor: 3.951
2015 SCImago Journal Rankings: 1.763

 

DC FieldValueLanguage
dc.contributor.authorChan, SCen_HK
dc.contributor.authorLiu, CLen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:45:50Z-
dc.date.available2010-09-06T08:45:50Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 10th Annual Congress of the International Liver Transplantation Society, Kyoto, Japan, 9-12 June 2004.en_HK
dc.identifier.issn1527-6465en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83838-
dc.description.abstractBackground Donor right hepatectomy subjects a healthy donor to an ultra-major surgical operation only for the benefit of the recipient. This has become a standard treatment modality to partially relieve the refractory shortage of cadaveric liver grafts. Justification of this procedure ought to be made with the full knowledge of the potential negative effects on the donor. Psychosocial assessment and monitoring of the donor has to be an integral part of such program. Aim of study To quantify the impact of donor right hepatectomy including the middle hepatic vein on donor quality of life before and after surgery longitudinally. Materials and methods Questionnaires with condition specific and generic components were completed by a face-to-face interview by one of the two full-time liver transplantation coordinators before operation, and 1, 2, 3, 6, and 12 months after operation. The generic instruments used were Karnofsky Performance Status, and the Chinese (Hong Kong) version of the Medical Outcomes Study 36-Item Short-form Survey. The latter measures eight concepts: physical functioning, physical role, emotional role, social functioning, bodily pain, mental health, vitality, and general health. Condition specific questions were also included. Results Between November 2002 and November 2003, 30 consecutive donors who underwent donor right hepatectomy including the middle hepatic vein were assessed and monitored prospectively before and after surgery. They were aged 35 years (21 to 56), with male to female ratio of 33.3%:66.7%. The median follow-up was 6 months (2 to 12). All except 1 were Chinese (1 Indian). There was no donor mortality or major complications. All the donors completed the questionnaires on schedule. Donor quality of life before surgery was excellent physically as they were by definition healthy individuals. The worsening was most significant in the 1st to 3rd month post-operatively, especially in the domains of physical functioning and bodily pain. These and other psychological aspects returned to the previous levels in 6 months’ time. 86.7% (N=26) of these donors reckoned that their donor experience was positive. Conclusion Donor quality of life was adversely affected immediately following surgery. Return to previous levels could be expected at 6 month in large majority of donors. Live donor liver transplantation seems to be acceptable for the rescue of recipients with end-stage liver disease as adverse changes in donor quality of health is temporary.-
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021en_HK
dc.relation.ispartofLiver Transplantationen_HK
dc.rightsLiver Transplantation. Copyright © John Wiley & Sons, Inc.en_HK
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.titleDonor quality of life before and after adult-to-adult live donor liver transplantationen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1527-6465&volume=10&issue=6&spage=C&epage=15 Abstract no. 59&date=2004&atitle=Donor+quality+of+life+before+and+after+adult-to-adult+live+donor+liver+transplantationen_HK
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_HK
dc.identifier.emailLiu, CL: clliu@hkucc.hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hk-
dc.identifier.authorityChan, SC=rp01568en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.doi10.1002/lt.20208-
dc.identifier.hkuros90742en_HK
dc.identifier.hkuros90740-
dc.identifier.volume10-
dc.identifier.issue6-
dc.identifier.spageC-15 Abstract no. 59-
dc.identifier.epageC-15 Abstract no. 59-

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