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Article: Carotid Intima-media Thickness in Patients with Abdominal Aortic Aneurysms

TitleCarotid Intima-media Thickness in Patients with Abdominal Aortic Aneurysms
Authors
KeywordsAbdominal aortic aneurysm
Carotid
IMT
Issue Date2007
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvs
Citation
European Journal Of Vascular And Endovascular Surgery, 2007, v. 33 n. 2, p. 149-153 How to Cite?
AbstractObjective: The contribution of atherosclerosis to the development of Abdominal Aortic Aneurysms (AAA) is still controversial. Ultrasound scans can detect intima-media thickening of the carotid arteries as an early sign of atherosclerosis. The aim of this study was to investigate whether patients with Abdominal Aortic Aneurysms (AAAs) have thickened carotid IMT as patients with atherosclerotic peripheral arterial disease (PAD). Methods: With high-resolution B-mode ultrasonography, the intima-media thickness (IMT) in the carotid arteries (right and left common carotid artery) was measured in AAA patients and compared with that of age and sex-matched patients with atherosclerotic peripheral arterial disease (PAD). A third group of healthy age and sex- matched control subjects were included for comparison. The corresponding carotid artery lumen was also determined in all groups. Comparison of the three groups was made by ANOVA. Results: Fifty-eight AAA patients and 69% were men (mean age of 72.3 years) were studied. Aged and sex-matched groups comprised of 111 PAD patients and 71 healthy. The mean carotid IMT was highest in PAD patients (1.036 ± 0.18 mm). The values of controls and AAA patients were similar and significantly lower than that of atherosclerotic patients (0.875 ± 0.11 mm and 0.812 ± 0.53 mm respectively, both p < 0.005 vs. PAD). Narrowing of the corresponding lumen was found in PAD patients compared with that of AAA patients, but no difference can be seen between healthy subjects and AAA patients. The mean carotid IMT was greater in men (P < 0.05) in all studied groups, but no similar gender specificity was found in the lumen diameter. Conclusions: This study shows that the carotid artery IMT of AAA patients is similar to healthy subjects, but not as thick as patients with atherosclerotic disease. As carotid (IMT) is a surrogate marker of atherosclerosis, the findings support the notion that the formation of AAA may not be fully atherosclerosis-dependent. Gender may be a confounding factor for carotid intima-media thickening. © 2006 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/83820
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.723
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheuk, BLYen_HK
dc.contributor.authorLau, SSFen_HK
dc.contributor.authorCheng, SWKen_HK
dc.date.accessioned2010-09-06T08:45:36Z-
dc.date.available2010-09-06T08:45:36Z-
dc.date.issued2007en_HK
dc.identifier.citationEuropean Journal Of Vascular And Endovascular Surgery, 2007, v. 33 n. 2, p. 149-153en_HK
dc.identifier.issn1078-5884en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83820-
dc.description.abstractObjective: The contribution of atherosclerosis to the development of Abdominal Aortic Aneurysms (AAA) is still controversial. Ultrasound scans can detect intima-media thickening of the carotid arteries as an early sign of atherosclerosis. The aim of this study was to investigate whether patients with Abdominal Aortic Aneurysms (AAAs) have thickened carotid IMT as patients with atherosclerotic peripheral arterial disease (PAD). Methods: With high-resolution B-mode ultrasonography, the intima-media thickness (IMT) in the carotid arteries (right and left common carotid artery) was measured in AAA patients and compared with that of age and sex-matched patients with atherosclerotic peripheral arterial disease (PAD). A third group of healthy age and sex- matched control subjects were included for comparison. The corresponding carotid artery lumen was also determined in all groups. Comparison of the three groups was made by ANOVA. Results: Fifty-eight AAA patients and 69% were men (mean age of 72.3 years) were studied. Aged and sex-matched groups comprised of 111 PAD patients and 71 healthy. The mean carotid IMT was highest in PAD patients (1.036 ± 0.18 mm). The values of controls and AAA patients were similar and significantly lower than that of atherosclerotic patients (0.875 ± 0.11 mm and 0.812 ± 0.53 mm respectively, both p < 0.005 vs. PAD). Narrowing of the corresponding lumen was found in PAD patients compared with that of AAA patients, but no difference can be seen between healthy subjects and AAA patients. The mean carotid IMT was greater in men (P < 0.05) in all studied groups, but no similar gender specificity was found in the lumen diameter. Conclusions: This study shows that the carotid artery IMT of AAA patients is similar to healthy subjects, but not as thick as patients with atherosclerotic disease. As carotid (IMT) is a surrogate marker of atherosclerosis, the findings support the notion that the formation of AAA may not be fully atherosclerosis-dependent. Gender may be a confounding factor for carotid intima-media thickening. © 2006 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvsen_HK
dc.relation.ispartofEuropean Journal of Vascular and Endovascular Surgeryen_HK
dc.subjectAbdominal aortic aneurysmen_HK
dc.subjectCarotiden_HK
dc.subjectIMTen_HK
dc.titleCarotid Intima-media Thickness in Patients with Abdominal Aortic Aneurysmsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1078-5884&volume=33&issue=2&spage=149&epage=153&date=2007&atitle=Carotid+intima-media+thickness+in+patients+with+abdominal+aortic+aneurysmsen_HK
dc.identifier.emailCheuk, BLY: bernice@hku.hken_HK
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hken_HK
dc.identifier.authorityCheuk, BLY=rp01671en_HK
dc.identifier.authorityCheng, SWK=rp00374en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejvs.2006.09.008en_HK
dc.identifier.pmid17097902-
dc.identifier.scopuseid_2-s2.0-33846148967en_HK
dc.identifier.hkuros126566en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846148967&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue2en_HK
dc.identifier.spage149en_HK
dc.identifier.epage153en_HK
dc.identifier.isiWOS:000244247500004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheuk, BLY=7801343617en_HK
dc.identifier.scopusauthoridLau, SSF=9234106700en_HK
dc.identifier.scopusauthoridCheng, SWK=7404684779en_HK

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