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Article: Analysis of factors affecting long-term survival of patients with hepatocellular carcinoma following hepatectomy

TitleAnalysis of factors affecting long-term survival of patients with hepatocellular carcinoma following hepatectomy
Authors
Keywordshepatocellular carcinoma
prognosis
surgery
Issue Date1994
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00534/index.htm
Citation
Journal Of Hepato-Biliary-Pancreatic Surgery, 1994, v. 1 n. 2, p. 113-117 How to Cite?
AbstractThe survival of 200 patients (172 males, 28 females; mean age ± SD: 53.6 ± 12 years) who underwent hepatectomy for hepatocellular carcinoma (HCC) was analyzed retrospectively to identify prognostic determinants to guide patient selection for appropriate treatment. All patients studied had had complete macroscopic extirpation of their tumor, histologic information regarding their lesions and the adjacent non-tumorous liver parenchyma, and no evidence of residual or recurrent disease 30 days after surgery. Survival was analyzed with reference to 25 different clinical (n=7), serological (n=2), macroscopic (n=4), and histological (n=12) features of the resected specimens, by using multivariate analysis. Recurrent HCC was detected in 138 patients within a median follow-up period of 12.6 months. While 33 patients had extra-hepatic disease alone, in 74, the recurrence was confined to the hepatic remnant. Survival at 1, 3, and 5 years was 58%, 34%, and 26%, respectively. The presence of residual histologic disease at the resection margin was found to be the only important prognostic determinant (P < 0.02). The distance of the macroscopic resection margin, either at 1 or 2 cm, made no difference to the long-term outcome of our patients. Following hepatectomy, a detailed pathologic examination of the resected liver specimen is mandatory to verify the status of disease clearance, as the distance of the gross surgical margin is an unreliable index. © 1994 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/83816
ISSN
2009 Impact Factor: 1.601

 

DC FieldValueLanguage
dc.contributor.authorLai, ECSen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T08:45:33Z-
dc.date.available2010-09-06T08:45:33Z-
dc.date.issued1994en_HK
dc.identifier.citationJournal Of Hepato-Biliary-Pancreatic Surgery, 1994, v. 1 n. 2, p. 113-117en_HK
dc.identifier.issn0944-1166en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83816-
dc.description.abstractThe survival of 200 patients (172 males, 28 females; mean age ± SD: 53.6 ± 12 years) who underwent hepatectomy for hepatocellular carcinoma (HCC) was analyzed retrospectively to identify prognostic determinants to guide patient selection for appropriate treatment. All patients studied had had complete macroscopic extirpation of their tumor, histologic information regarding their lesions and the adjacent non-tumorous liver parenchyma, and no evidence of residual or recurrent disease 30 days after surgery. Survival was analyzed with reference to 25 different clinical (n=7), serological (n=2), macroscopic (n=4), and histological (n=12) features of the resected specimens, by using multivariate analysis. Recurrent HCC was detected in 138 patients within a median follow-up period of 12.6 months. While 33 patients had extra-hepatic disease alone, in 74, the recurrence was confined to the hepatic remnant. Survival at 1, 3, and 5 years was 58%, 34%, and 26%, respectively. The presence of residual histologic disease at the resection margin was found to be the only important prognostic determinant (P < 0.02). The distance of the macroscopic resection margin, either at 1 or 2 cm, made no difference to the long-term outcome of our patients. Following hepatectomy, a detailed pathologic examination of the resected liver specimen is mandatory to verify the status of disease clearance, as the distance of the gross surgical margin is an unreliable index. © 1994 Springer-Verlag.en_HK
dc.languageengen_HK
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00534/index.htmen_HK
dc.relation.ispartofJournal of Hepato-Biliary-Pancreatic Surgeryen_HK
dc.subjecthepatocellular carcinomaen_HK
dc.subjectprognosisen_HK
dc.subjectsurgeryen_HK
dc.titleAnalysis of factors affecting long-term survival of patients with hepatocellular carcinoma following hepatectomyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0944-1166&volume=2&spage=113&epage=117&date=1994&atitle=Analysis+of+factors+affecting+long-term+survival+of+patients+with+hepatocellular+carcinoma+following+hepatectomyen_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/BF01222232en_HK
dc.identifier.scopuseid_2-s2.0-34249769906en_HK
dc.identifier.hkuros3739en_HK
dc.identifier.volume1en_HK
dc.identifier.issue2en_HK
dc.identifier.spage113en_HK
dc.identifier.epage117en_HK
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridLai, ECS=36932159600en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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