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Conference Paper: Hepatocyte growth factor in human esophageal squamous cell carcinomas is an independent prognostic factor

TitleHepatocyte growth factor in human esophageal squamous cell carcinomas is an independent prognostic factor
Authors
Issue Date2004
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DES
Citation
IX World Congress of the International Society for Diseases of the Esophagus, Madrid, Spain, 27-29 May 2004. How to Cite?
AbstractPurpose Hepatocyte growth factor/scatter factor (HGF/SF) and its receptor c-Met, play important roles in tumor development and progression. In this study, we measured the serum HGF levels in patients with esophageal squamous cell carcinoma (ESCC) to evaluate its relationships with clinicopathologic features, prognosis, and angiogenic factors. Experimental design One hundred and forty-nine patients with ESCC were included in the study. Pre-therapy serum was collected and ELISA was used to detect the concentrations of HGF, vascular endothelial growth factor (VEGF) and interleukin 8 (IL-8). HGF and c-Met in tissue specimens and cell lines were assayed by immunohistochemical staining and flow cytometry, respectively. Results Pre-therapy serum HGF was found to be significantly higher in patients with ESCC than in healthy subjects. The levels of HGF correlated significantly with M stage, advanced TNM stage and survival. Multivariate analyses showed that serum HGF level, TNM stage, surgical resection, and the use of chemoradiation therapy were independent prognostic factors. Increased HGF serum levels also correlated positively with serum levels of VEGF and IL-8. Immunohistochemical staining showed that the onco-protein c-Met was expressed in esophageal tumor cells from esophagectomy specimens and ESCC cell lines, while HGF was mainly expressed by tumor cells and stromal cells such as infiltrated cells, endothelial cells and fibroblasts. Conclusion Our results suggest that HGF may be involved in the progression of ESCC as a autocrine/paracrine factor. These findings also indicate that serum HGF may be a useful biomarker of tumor progression and a valuable independent prognostic factor in patients with ESCC.
DescriptionDiseases of the Esophagus, v. 17 n. Supplement 1, p. A101-A102, Abstract no. 126
Persistent Identifierhttp://hdl.handle.net/10722/83756
ISSN
2015 Impact Factor: 2.146
2015 SCImago Journal Rankings: 0.760

 

DC FieldValueLanguage
dc.contributor.authorRen, Yen_HK
dc.date.accessioned2010-09-06T08:44:50Z-
dc.date.available2010-09-06T08:44:50Z-
dc.date.issued2004en_HK
dc.identifier.citationIX World Congress of the International Society for Diseases of the Esophagus, Madrid, Spain, 27-29 May 2004.-
dc.identifier.issn1120-8694en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83756-
dc.descriptionDiseases of the Esophagus, v. 17 n. Supplement 1, p. A101-A102, Abstract no. 126-
dc.description.abstractPurpose Hepatocyte growth factor/scatter factor (HGF/SF) and its receptor c-Met, play important roles in tumor development and progression. In this study, we measured the serum HGF levels in patients with esophageal squamous cell carcinoma (ESCC) to evaluate its relationships with clinicopathologic features, prognosis, and angiogenic factors. Experimental design One hundred and forty-nine patients with ESCC were included in the study. Pre-therapy serum was collected and ELISA was used to detect the concentrations of HGF, vascular endothelial growth factor (VEGF) and interleukin 8 (IL-8). HGF and c-Met in tissue specimens and cell lines were assayed by immunohistochemical staining and flow cytometry, respectively. Results Pre-therapy serum HGF was found to be significantly higher in patients with ESCC than in healthy subjects. The levels of HGF correlated significantly with M stage, advanced TNM stage and survival. Multivariate analyses showed that serum HGF level, TNM stage, surgical resection, and the use of chemoradiation therapy were independent prognostic factors. Increased HGF serum levels also correlated positively with serum levels of VEGF and IL-8. Immunohistochemical staining showed that the onco-protein c-Met was expressed in esophageal tumor cells from esophagectomy specimens and ESCC cell lines, while HGF was mainly expressed by tumor cells and stromal cells such as infiltrated cells, endothelial cells and fibroblasts. Conclusion Our results suggest that HGF may be involved in the progression of ESCC as a autocrine/paracrine factor. These findings also indicate that serum HGF may be a useful biomarker of tumor progression and a valuable independent prognostic factor in patients with ESCC.-
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DESen_HK
dc.relation.ispartofDiseases of the Esophagusen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.titleHepatocyte growth factor in human esophageal squamous cell carcinomas is an independent prognostic factoren_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1120-8694&volume=17&issue=Supplement 1&spage=A101&epage=A102&date=2004&atitle=Hepatocyte+growth+factor+in+human+esophageal+squamous+cell+carcinomas+is+an+independent+prognostic+factoren_HK
dc.identifier.emailRen, Y: yren@hkucc.hku.hken_HK
dc.identifier.hkuros92024en_HK
dc.identifier.volume17-
dc.identifier.issueSupplement 1-
dc.identifier.spageA101-
dc.identifier.epageA102-

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