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Article: Liver transplantation for solitary hepatocellular carcinoma less than 3 cm in diameter in Child A cirrhosis

TitleLiver transplantation for solitary hepatocellular carcinoma less than 3 cm in diameter in Child A cirrhosis
Authors
KeywordsCirrhosis
Hepatocellular carcinoma
Liver transplantation
Radiofrequency ablation
Resection
Issue Date2007
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DDI
Citation
Digestive Diseases, 2007, v. 25 n. 4, p. 334-340 How to Cite?
AbstractLiver transplantation for hepatocellular carcinoma (HCC) is the treatment of choice for patients with unresectable tumors within the Milan criteria associated with Child B or C cirrhosis. Liver transplantation provides the best cure for both the HCC and the underlying cirrhosis. In recent years, some authors have advocated liver transplantation even for resectable early HCC associated with Child A cirrhosis, leading to a controversy of whether resection or transplantation should be the first-line therapy for patients with small HCC in Child A cirrhosis. Recent studies comparing liver resection and transplantation for early HCC demonstrated similar long-term survival of 60-70%, but liver transplantation is associated with a lower tumor recurrence rate. However, the current shortage of deceased donor liver grafts limits the applicability of liver transplantation for HCC. The use of live donor liver transplantation for patients with a small solitary HCC in Child A cirrhosis that is resectable may not be justified ethically because of the potential risk to the donors. Patients put on a transplantation waiting list run a significant risk of tumor progression and dropout, while liver resection is immediately applicable to all. Advocating primary liver transplantation for patients with early HCC associated with compensated cirrhosis will increase the waiting time for transplantation and further increases the chance of dropout. Resection first and salvage transplantation for recurrent tumors or liver failure is an alternative strategy that may reduce the use of liver grafts. However, the long-term survival result of such a strategy compared with primary liver transplantation remains unclear. Copyright © 2007 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/83723
ISSN
2015 Impact Factor: 1.777
2015 SCImago Journal Rankings: 0.877
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoon, RTPen_HK
dc.date.accessioned2010-09-06T08:44:27Z-
dc.date.available2010-09-06T08:44:27Z-
dc.date.issued2007en_HK
dc.identifier.citationDigestive Diseases, 2007, v. 25 n. 4, p. 334-340en_HK
dc.identifier.issn0257-2753en_HK
dc.identifier.urihttp://hdl.handle.net/10722/83723-
dc.description.abstractLiver transplantation for hepatocellular carcinoma (HCC) is the treatment of choice for patients with unresectable tumors within the Milan criteria associated with Child B or C cirrhosis. Liver transplantation provides the best cure for both the HCC and the underlying cirrhosis. In recent years, some authors have advocated liver transplantation even for resectable early HCC associated with Child A cirrhosis, leading to a controversy of whether resection or transplantation should be the first-line therapy for patients with small HCC in Child A cirrhosis. Recent studies comparing liver resection and transplantation for early HCC demonstrated similar long-term survival of 60-70%, but liver transplantation is associated with a lower tumor recurrence rate. However, the current shortage of deceased donor liver grafts limits the applicability of liver transplantation for HCC. The use of live donor liver transplantation for patients with a small solitary HCC in Child A cirrhosis that is resectable may not be justified ethically because of the potential risk to the donors. Patients put on a transplantation waiting list run a significant risk of tumor progression and dropout, while liver resection is immediately applicable to all. Advocating primary liver transplantation for patients with early HCC associated with compensated cirrhosis will increase the waiting time for transplantation and further increases the chance of dropout. Resection first and salvage transplantation for recurrent tumors or liver failure is an alternative strategy that may reduce the use of liver grafts. However, the long-term survival result of such a strategy compared with primary liver transplantation remains unclear. Copyright © 2007 S. Karger AG.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DDIen_HK
dc.relation.ispartofDigestive Diseasesen_HK
dc.rightsDigestive Diseases. Copyright © S Karger AG.en_HK
dc.subjectCirrhosisen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectLiver transplantationen_HK
dc.subjectRadiofrequency ablationen_HK
dc.subjectResectionen_HK
dc.titleLiver transplantation for solitary hepatocellular carcinoma less than 3 cm in diameter in Child A cirrhosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0257-2753&volume=25&issue=4&spage=334&epage=340&date=2007&atitle=Liver+transplantation+for+solitary+hepatocellular+carcinoma+less+than+3+cm+in+diameter+in+Child+A+cirrhosisen_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000106914en_HK
dc.identifier.pmid17960069-
dc.identifier.scopuseid_2-s2.0-35548945420en_HK
dc.identifier.hkuros139482en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35548945420&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue4en_HK
dc.identifier.spage334en_HK
dc.identifier.epage340en_HK
dc.identifier.isiWOS:000250506900009-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK

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