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Article: Craniofacial surgery for malignant skull base tumors: Report of an international collaborative study

TitleCraniofacial surgery for malignant skull base tumors: Report of an international collaborative study
Authors
KeywordsInternational cooperation
Postoperative complications
Skull base neoplasms/mortality
Skull base neoplasms/surgery
Treatment outcome
Issue Date2003
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2003, v. 98 n. 6, p. 1179-1187 How to Cite?
AbstractBACKGROUND. Malignant tumors of the skull base are rare. Therefore, no single center treats enough patients to accumulate significant numbers for meaningful analysis of outcomes after craniofacial surgery (CFS). The current report was based on a large cohort that was analyzed retrospectively by an International Collaborative Study Group. METHODS. One thousand three hundred seven patients who underwent CFS in 17 institutions were analyzable for outcome. The median age was 54 years (range, 1-98 years). Definitive treatment prior to CFS had been administered in 59% of patients and included radiotherapy in 367 patients (28%), chemotherapy in 151 patients (12%), and surgery in 523 patients (40%). The majority of tumors (87%) involved the anterior cranial fossa. Squamous cell carcinoma (29%) and adenocarcinoma (16%) were the most common histologic types. The margins of surgical resection were reported close/ positive in 412 patients (32%). Adjuvant postoperative radiotherapy was received by 510 patients (39%), and chemotherapy was received by 57 patients (4%). RESULTS. Postoperative complications were reported in 433 patients (33%), with local wound complications the most common (18%). The postoperative mortality rate was 4%. With a median follow-up of 25 months, the 5-year overall, disease-specific, and recurrence-free survival rates were 54%, 60%, and 53%, respectively. The histology of the primary tumor, its intracranial extent, and the status of surgical margins were independent predictors of overall, disease-specific, and recurrence-free survival on multivariate analysis. CONCLUSIONS. CFS is a safe and effective treatment option for patients with malignant tumors of the skull base. The histology of the primary tumor, its intracranial extent, and the status of surgical margins are independent determinants of outcome. © 2003 American Cancel' Society.
Persistent Identifierhttp://hdl.handle.net/10722/83721
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPatel, SGen_HK
dc.contributor.authorSingh, Ben_HK
dc.contributor.authorPolluri, Aen_HK
dc.contributor.authorBridger, PGen_HK
dc.contributor.authorCantu, Gen_HK
dc.contributor.authorCheesman, ADen_HK
dc.contributor.authorDeSa, GMen_HK
dc.contributor.authorDonald, Pen_HK
dc.contributor.authorFliss, Den_HK
dc.contributor.authorGullane, Pen_HK
dc.contributor.authorJanecka, Ien_HK
dc.contributor.authorKamata, SEen_HK
dc.contributor.authorKowalski, LPen_HK
dc.contributor.authorKraus, DHen_HK
dc.contributor.authorLevine, PAen_HK
dc.contributor.authorDos Santos, LRMen_HK
dc.contributor.authorPradhan, Sen_HK
dc.contributor.authorSchramm, Ven_HK
dc.contributor.authorSnyderman, Cen_HK
dc.contributor.authorWei, WIen_HK
dc.contributor.authorShah, JPen_HK
dc.date.accessioned2010-09-06T08:44:25Z-
dc.date.available2010-09-06T08:44:25Z-
dc.date.issued2003en_HK
dc.identifier.citationCancer, 2003, v. 98 n. 6, p. 1179-1187en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/83721-
dc.description.abstractBACKGROUND. Malignant tumors of the skull base are rare. Therefore, no single center treats enough patients to accumulate significant numbers for meaningful analysis of outcomes after craniofacial surgery (CFS). The current report was based on a large cohort that was analyzed retrospectively by an International Collaborative Study Group. METHODS. One thousand three hundred seven patients who underwent CFS in 17 institutions were analyzable for outcome. The median age was 54 years (range, 1-98 years). Definitive treatment prior to CFS had been administered in 59% of patients and included radiotherapy in 367 patients (28%), chemotherapy in 151 patients (12%), and surgery in 523 patients (40%). The majority of tumors (87%) involved the anterior cranial fossa. Squamous cell carcinoma (29%) and adenocarcinoma (16%) were the most common histologic types. The margins of surgical resection were reported close/ positive in 412 patients (32%). Adjuvant postoperative radiotherapy was received by 510 patients (39%), and chemotherapy was received by 57 patients (4%). RESULTS. Postoperative complications were reported in 433 patients (33%), with local wound complications the most common (18%). The postoperative mortality rate was 4%. With a median follow-up of 25 months, the 5-year overall, disease-specific, and recurrence-free survival rates were 54%, 60%, and 53%, respectively. The histology of the primary tumor, its intracranial extent, and the status of surgical margins were independent predictors of overall, disease-specific, and recurrence-free survival on multivariate analysis. CONCLUSIONS. CFS is a safe and effective treatment option for patients with malignant tumors of the skull base. The histology of the primary tumor, its intracranial extent, and the status of surgical margins are independent determinants of outcome. © 2003 American Cancel' Society.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectInternational cooperationen_HK
dc.subjectPostoperative complicationsen_HK
dc.subjectSkull base neoplasms/mortalityen_HK
dc.subjectSkull base neoplasms/surgeryen_HK
dc.subjectTreatment outcomeen_HK
dc.titleCraniofacial surgery for malignant skull base tumors: Report of an international collaborative studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=98&issue=6&spage=1179&epage=1187&date=2003&atitle=Craniofacial+surgery+for+malignant+skull+base+tumors:+report+of+an+international+collaborative+studyen_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/cncr.11630en_HK
dc.identifier.pmid12973841en_HK
dc.identifier.scopuseid_2-s2.0-0041917133en_HK
dc.identifier.hkuros85400en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0041917133&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume98en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1179en_HK
dc.identifier.epage1187en_HK
dc.identifier.isiWOS:000185276800009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPatel, SG=7403903141en_HK
dc.identifier.scopusauthoridSingh, B=7405639360en_HK
dc.identifier.scopusauthoridPolluri, A=6505641537en_HK
dc.identifier.scopusauthoridBridger, PG=6603845621en_HK
dc.identifier.scopusauthoridCantu, G=7003498793en_HK
dc.identifier.scopusauthoridCheesman, AD=7003676128en_HK
dc.identifier.scopusauthoridDeSa, GM=6507638814en_HK
dc.identifier.scopusauthoridDonald, P=7103189603en_HK
dc.identifier.scopusauthoridFliss, D=7005455625en_HK
dc.identifier.scopusauthoridGullane, P=7005484642en_HK
dc.identifier.scopusauthoridJanecka, I=7005569375en_HK
dc.identifier.scopusauthoridKamata, SE=35478208000en_HK
dc.identifier.scopusauthoridKowalski, LP=7102126040en_HK
dc.identifier.scopusauthoridKraus, DH=25947461900en_HK
dc.identifier.scopusauthoridLevine, PA=35386674700en_HK
dc.identifier.scopusauthoridDos Santos, LRM=7005029659en_HK
dc.identifier.scopusauthoridPradhan, S=7202877432en_HK
dc.identifier.scopusauthoridSchramm, V=35511790400en_HK
dc.identifier.scopusauthoridSnyderman, C=7005989580en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.scopusauthoridShah, JP=7403266008en_HK

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